Publication Date:
1997-03-28
Description:
The transcription factor NF-AT responds to Ca2+-calcineurin signals by translocating to the nucleus, where it participates in the activation of early immune response genes. Calcineurin dephosphorylates conserved serine residues in the amino terminus of NF-AT, resulting in nuclear import. Purification of the NF-AT kinase revealed that it is composed of a priming kinase activity and glycogen synthase kinase-3 (GSK-3). GSK-3 phosphorylates conserved serines necessary for nuclear export, promotes nuclear exit, and thereby opposes Ca2+-calcineurin signaling. Because GSK-3 responds to signals initiated by Wnt and other ligands, NF-AT family members could be effectors of these pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beals, C R -- Sheridan, C M -- Turck, C W -- Gardner, P -- Crabtree, G R -- New York, N.Y. -- Science. 1997 Mar 28;275(5308):1930-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9072970" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Biological Transport
;
Brain/enzymology
;
COS Cells
;
Calcineurin
;
Calcium/metabolism
;
Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
;
Calmodulin-Binding Proteins/metabolism
;
Cell Nucleus/*metabolism
;
Cloning, Molecular
;
Cyclic AMP-Dependent Protein Kinases/metabolism
;
DNA-Binding Proteins/genetics/*metabolism
;
Glycogen Synthase Kinase 3
;
Glycogen Synthase Kinases
;
Humans
;
Molecular Sequence Data
;
NFATC Transcription Factors
;
*Nuclear Proteins
;
Phosphoprotein Phosphatases/metabolism
;
Phosphorylation
;
Rats
;
Recombinant Fusion Proteins/metabolism
;
Signal Transduction
;
Transcription Factors/genetics/*metabolism
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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