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  • Chemistry  (10)
  • Research and Support Facilities (Air)  (2)
  • tau  (2)
  • Cell & Developmental Biology
  • 1995-1999  (15)
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Keywords
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    The Order of Exposure of Tau to Signal Transduction Kinases Alters the Generation of “AD-Like” Phosphoepitopes (1999)
    Springer
    Cellular and molecular neurobiology 19 (1999), S. 223-233 
    Details
    ISSN: 1573-6830
    Keywords: tau ; kinases ; signal transduction ; Alzheimer's disease ; phosphorylation ; paired helical filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. The individual and sequential influence of protein kinase C (PKC), protein kinase A (PKA) and mitogen-activated protein kinase (MAP kinase) on human brain tau was examined. 2. A range of PKC concentrations generated certain phosphoepitopes common with paired helical filaments. These epitopes were masked by higher PKC concentrations, suggesting the presence of multiple tau phosphorylation sites for which PKC exhibited differing affinities and/or conformational alterations in tau induced by sequential PKC-mediated phosphorylation. 3. Prior phosphorylation by PKC enhanced the nature and extent of AD-like tau antigenicity generated by subsequent incubation with MAP kinase yet inhibited that generated by subsequent incubation with PKA. 4. Dephosphorylation of tau prior to incubation with kinases significantly altered the influence of individual and multiple kinase incubation on tau antigenicity in a site-specific manner, indicating that prior in situ phosphorylation events markedly influenced subsequent cell-free phosphorylation. 5. In addition to considerations of the potential impact of tau phosphorylation by individual kinases, these findings extend previous studies which indicate that tau antigenicity, and, presumably, its behavior in situ, is influenced by the sequential and convergent influences of multiple kinases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006977127422
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  • 2
    Electronic Resource
    Electronic Resource
    Hyperactivation of Mitogen-Activated Protein Kinase Increases Phospho-Tau Immunoreactivity Within Human Neuroblastoma: Additive and Synergistic Influence of Alteration of Additional Kinase Activities (1999)
    Springer
    Cellular and molecular neurobiology 19 (1999), S. 249-260 
    Details
    ISSN: 1573-6830
    Keywords: MAP kinase ; tau ; protein kinase C ; wortmannin ; PD98059 ; neuroblastoma ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Mitogen-activated protein (MAP) kinase phosphorylates tau in cell-free analyses, but whether or not it does so within intact cells remains controversial. In the present study, microinjection of MAP kinase into SH-SY-5Y human neuroblastoma cells increased tau immunoreactivity toward the phosphodependent antibodies PHF-1 and AT-8. In contrast, treatment with a specific inhibitor of MAP kinase (PD98059) did not diminish “basal” levels of these immunoreactivities in otherwise untreated cells. These findings indicate that hyperactivation of MAP kinase increases phospho-tau levels within cells, despite that MAP kinase apparently does not substantially influence intracellular tau phosphorylation under normal conditions. These findings underscore that results obtained following inhibition of kinase activities do not necessarily provide an indication of the consequences accompanying hyperactivation of that same kinase. Several studies conducted in cell-free systems indicate that exposure of tau to multiple kinases can have synergistic effects on the nature and extent of tau phosphorylation. We therefore examined whether or not such effects could be demonstrated within these cells. Site-specific phospho-tau immunoreactivity was increased in additive and synergistic manners by treatment of injected cells with TPA (which activates PKC), calcium ionophore (which activates calcium-dependent kinases), and wortmannin (which inhibits PIP3 kinase). Alteration in total tau levels was insufficient to account for the full extent of the increase in phospho-tau immunoreactivity. These additional results indicate that multiple kinase activities modulate the influence of MAP kinase on tau within intact cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006981228331
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  • 3
    Electronic Resource
    Electronic Resource
    Osteoblast migration on poly(α-hydroxy esters) (1996)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 50 (1996), S. 443-451 
    Details
    ISSN: 0006-3592
    Keywords: osteoblast ; migration ; poly(αhydroxy esters) ; poly(DL-lactic-co-glycolic acid) ; PLGA ; biodegradable polymers ; tissue engineering ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: We investigated the migration of rat calvaria osteoblast populations on poly(α-hydroxy ester) films for up to 14 days to determine effects of substrate composition and culture conditions on the migratory characteristics of osteoblasts. Initial osteoblast culture conditions included cell colonies formed by seeding a high (84,000 cells/cm2) or low (42,000 cells/cm2) density of isolated osteoblasts on the polymer films, and bone tissue cultures formed by plating bone chips directly on the substrates. High density osteoblast colonies cultured and allowed to migrate and proliferate radially on 85:15 poly(DL-lactic-co-glycolic acid) (PLGA) films, 75:25 PLGA films, and tissue culture polystyrene controls demonstrated that the copolymer ratio in the polymer films did not affect the rate of increase in substrate surface area (or culture area) covered by the growing cell colony. However, the rate of increase in culture area was dependent on the initial osteoblast seeding density. Initial cell colonies formed with a lower osteoblast seeding density on 75:25 PLGA resulted in a lower rate of increase in culture area, specifically 4.9 ± 0.3 mm2/day, versus 14.1 ± 0.7 mm2/day for colonies seeded with a higher density of cells on the same polymer films. The proliferation rate for osteoblasts in the high and low density seeded osteoblast colonies did not differ, whereas the proliferation rate for the osteoblasts arising from the bone chips was lower than either of these isolated cell colonies. Confocal and light microscopy revealed that the osteoblast migration occurred as a monolayer of individual osteoblasts and not a calcified tissue front. These results demonstrated that cell seeding conditions strongly affect the rates of osteoblast migration and proliferation on biodegradable poly(α-hydroxy esters). © 1996 John Wiley & Sons, Inc.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Perimeter Exploration of Linear Chains of Circles (1995)
    Weinheim : Wiley-Blackwell
    Particle and Particle Systems Characterization 12 (1995), S. 257-263 
    Details
    ISSN: 0934-0866
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Perimeter data, obtained from structured walks performed upon straight chains of circles and displayed in Richardson plots, reveal two distinct classes of discontinuities: textural and structural. Textural discontinuities contain information about the surface features of the profile, while structural discontinuities reveal the profile's overall shape. The origins of both types of discontinuities have easy explanations. The highly predictable behavior of the structural discontinuities serves as the basis of a newly proposed method of analysis for perimeter data. The number of structural discontinuities is equal to N, the number of circles in the chain; furthermore, the value of the step size \documentclass{article}\pagestyle{empty}\begin{document}$ \underline {\lambda} $\end{document} * associated with the first structural discontinuity is inversely related to N. These properties seem is be retained when the circles slightly intersect and also when the circles vary in diameter. Analysis of the structural discontinuities may provide a new method suitable for automated examination of chain-like agglomerate particles.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ppsc.19950120508
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  • 5
    Electronic Resource
    Electronic Resource
    Bacteriorhodopsin α-helices in lipid settings: Insights for structure prediction (1998)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 69 (1998), S. 105-116 
    Details
    ISSN: 0020-7608
    Keywords: bacteriorhodopsin ; protein: lipid interactions ; α-helices ; molecular dynamics ; membrane protein tertiary structure prediction ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The two-stage model of membrane protein folding predicts that isolated transmembrane α-helices form stably in the bilayer before coming together to form the fully functional protein. Insight into the molecular implications of this model are possible with detailed molecular dynamics calculations. Thirty molecular dynamics simulations of both individual and pairs of α-helices from bacteriorhodopsin were calculated with the CHARMm program. This data base will continue to grow and expand. Already, differences between identical helices in different media and different helices in the same media have been found. The current results are summarized in this contribution.   © 1998 John Wiley & Sons, Inc. Int J Quant Chem 69: 105-116, 1998
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    A new approach to chemical characterization of polymer surfaces (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 58 (1995), S. 291-296 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The “three-liquid” contact angle procedure of Good et al. was applied to polymer films of varying Lewis acidic and basic nature to test the procedure. Surface energy parameters with the units of mJ/m2 are determined for the surfaces. These are γLWs (Lifshitz-van der Waals or apolar), γ+s (acidic), and γ-s (basic). Very little has yet been published on this new method, and this study found it to be promising. More research on the procedure is warranted. The study included films of basic polymethylmethacrylate (PMMA), and predominately acidic chlorinated polyvinylchloride (CPVC) and polyvinylfluoride (PVF) as well as the series: polyethylene (PE) and PE copolymerized with 1.8% and 7.0% acrylic acid. In some of the experiments receding contact angles were measured, and the surface energy parameters determined in order to cast more light on the mechanism of contact angle hysteresis. © 1995 John Wiley & Sons, Inc.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070580208
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  • 7
    Electronic Resource
    Electronic Resource
    Addition von Nitrilen an Metallsulfide: mögliche Informationen über metallsulfidkatalysierte Hydrierungen von Nitrilen und DistickstoffDiese Arbeit wurde von der National Science Foundation unterstützt. Wir danken Dr. S. Inomata für unveröffentlichte Ergebnisse. (1997)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 109 (1997), S. 2173-2175 
    Details
    ISSN: 0044-8249
    Keywords: Oxidoreduktasen ; Redoxchemie ; Rhenium ; Schwefel ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19971091914
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  • 8
    Electronic Resource
    Electronic Resource
    C4S62—: ein Bis(dithiolato)-Brückenligand für die Herstellung von anorganischen HalbleiterpolymerenDiese Arbeit wurde vom Department of Energy (DE-FG02-91ER45439) gefördert. L. F. S. dankt der National Science Foundation für ein Postdoktoranden-Stipendium. (1995)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 107 (1995), S. 2027-2029 
    Details
    ISSN: 0044-8249
    Keywords: Halbleiter ; Polymere ; Schwefelverbindungen ; Thione ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19951071723
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  • 9
    Electronic Resource
    Electronic Resource
    Metalloporphyrine als Liganden: Synthese und Charakterisierung von [(η6-cymol)Ru{η5-Ni(OEP)}]2+Diese Arbeit wurde vom U. S. Department of Energy unterstützt (DOE DEF-GO2-90ER14146). Das Fluorescence Dynamics Laboratory an der University of Illinois, Urbana-Champaign wird von der Division of Research Resources der National Institutes of Health unterstützt (PHS-P41-RRO3155). OEP = Octaethylporphyrin. (1996)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 108 (1996), S. 1985-1987 
    Details
    ISSN: 0044-8249
    Keywords: Metalloporphyrine ; Nickelverbindungen ; Rutheniumverbindungen ; Sandwichkomplexe ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19961081631
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  • 10
    Electronic Resource
    Electronic Resource
    Human senescence (1996)
    New York, NY : Wiley-Blackwell
    BioEssays 18 (1996), S. 1009-1016 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Human life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require integration of molecular, cellular, genetic and physiological approaches. This article reviews progress that has been made to date, particularly with regard to the genetic contribution to senescence and longevity, and assesses the scale of the task that remains.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950181211
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