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  • Geophysics  (5)
  • 550 - Earth sciences  (3)
  • Environment Pollution  (3)
  • AERODYNAMICS
  • Mice
  • 1995-1999  (12)
  • 1
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    The dependence of high-latitude Pc5 wave power on solar wind velocity and on the phase of high-speed solar wind streams. (1998)
    In:  Journal of Geophysical Research
    Details
    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
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  • 2
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    A multipoint determination of the propagation velcocity of a sudden commencement across the polar ionosphere. (1999)
    In:  Journal of Geophysical Research
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    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
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  • 3
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    The response of the magnetosphere to the passage of a coronal mass ejection on March 20-21, 1990 (1997)
    In:  Annales Geophysicae
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    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
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  • 4
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    Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999
    Description: Stable delivery of a therapeutic protein under pharmacologic control was achieved through in vivo somatic gene transfer. This system was based on the expression of two chimeric, human-derived proteins that were reconstituted by rapamycin into a transcription factor complex. A mixture of two adeno-associated virus vectors, one expressing the transcription factor chimeras and one containing erythropoietin (Epo) under the control of a promoter responsive to the transcription factor, was injected into skeletal muscle of immune-competent mice. Administration of rapamycin resulted in 200-fold induction of plasma Epo. Stable engraftment of this humanized system in immune-competent mice was achieved for 6 months with similar results for at least 3 months in a rhesus monkey.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ye, X -- Rivera, V M -- Zoltick, P -- Cerasoli, F Jr -- Schnell, M A -- Gao, G -- Hughes, J V -- Gilman, M -- Wilson, J M -- P01 AR/NS43648-03/AR/NIAMS NIH HHS/ -- P30 DK47757-05/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1999 Jan 1;283(5398):88-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9872748" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytomegalovirus/genetics ; Dependovirus/genetics ; Erythropoietin/administration & dosage/blood/*genetics ; Female ; Gene Expression Regulation ; *Gene Transfer Techniques ; Genetic Therapy/*methods ; Genetic Vectors ; Hematocrit ; Injections, Intramuscular ; Macaca mulatta ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Muscle, Skeletal ; Promoter Regions, Genetic ; Recombinant Fusion Proteins ; Recombinant Proteins ; Sirolimus/*pharmacology ; Transcription Factors/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Influence of Shock-Induced Ionospheric Conductivity Enhancements on Storm Main Phase Intensities (1999)
    In:  Other Sources
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    Publication Date: 2018-06-08
    Keywords: Geophysics
    Type: International Union of Geodesy and Geophysics (IUGG) '99; Birmingham; United Kingdom
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  • 6
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    Interball substorm observations: Christmas for space scientists (1996)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Observational results from the Interball Tail Probe spacecraft are presented. One of the main objectives of the Interball project is to study the dynamic processes in the magnetosphere. Three events observed by the spacecraft's instruments are investigated: a pseudobreakup during which earthward streaming ions were observed in the vicinity of a thin current sheet; a substorm in which the magnetic signatures in the lobe and on the ground were preceeded by northward re-orientation of the interplanetary magnetic field Bz component; and a magnetic storm at the beginning of which extreme deformation of the magnetotail was observed.
    Keywords: Geophysics
    Type: ; 497-506
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  • 7
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    Pinatubo Aerosol Global-to-Micro-Scale Evolution: A Unified Picture From Space, Air, and Ground Measurements (1995)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: We combine a variety of measurements to develop a composite picture of the post-Pinatubo aerosol and assess the consistency and uncertainties of the measurement and retrieval techniques Satellite infrared spectroscopy, particle morphology, and evaporation temperature measurements are in accord with theoretical calculations In showing a dominant particle composition of H2SO4-H2O mature with H2SO4 weight traction of 65-80% for most stratospheric temperatures and humidities. Important exceptions are: (1) the presence of volcanic ash at all attitudes initially and in a layer just above the tropopause until at least March 1992, and (2) much smaller H2SO4 weight fractions at the low temperatures attained In high latitude winters and at the tropical tropopause. Laboratory spectroscopy and theoretical calculations yield wavelength- and temperature-dependent refractive indices for the dominant H2SO4-H2O droplets. These in turn permit derivation of particle size spectra from measured optical depth spectra for comparison to direct measurements by impactors and optical counters, All three techniques paint a generally consistent picture of the evolution of R(sub eff) the effective, or area-weighted, particle radius. In the first month after the eruption, although particle numbers increased by orders of magnitude, R(sub eff) was similar to the pre-eruption value of 0.1 to 0.2 microns because both small (r less than 0.2 microns) and large (r greater than 0.6 microns) particles increased in number. Over the next 3-6 months, R(sub eff) increased to about 0.5 microns, reflecting particle growth through condensation and coagulation. In general, R(sub eff) continued to increase for about a year after the eruption. Extinction spectra computed from in situ size distribution measurements are consistent with optical depth measurements, which show spectra with maxima initially at wavelengths of 0.42 microns or less, and thereafter progressively increasing to between 0.78 and 1 micron. Not until 1993 does optical depth spectra begin to show a clear return to the preeruption signature of maximizing at the shortest visible wavelengths or in the near UV. This coupled evolution in particle size distribution and optical depth spectra helps explain the relationship between the global maps of 0.5- and 1.0-kilometer optical depth derived from the AVHRR and SAGE satellite measurements. It also sets a context for evaluating remaining uncertainties in each of these satellite data products. We also show how the effects of wavelength-dependent refractive index on backscatter spectra can influence particle sizes retrieved from multiwavelength lidar measurements.
    Keywords: Environment Pollution
    Type: American Association for Aerosol Research Annual Meeting; Oct 09, 1995 - Oct 13, 1995; Pittsburgh, PA; United States
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  • 8
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    Pinatubo Global- to Micro-Scale Evolution: A Unified Picture from Space, Air, and Ground Measurements (1995)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: We combine space, air, and ground measurements to develop a composite picture of the post-Pinatubo aerosol, and assess the consistency and uncertainties of various measurement and retrieval techniques. impactor and optical counter measurements, as well as retrievals from optical depth spectra, paint a generally consistent picture of the evolution of particle effective radii, R(sub eff). In the first month after the eruption, although particle numbers increased by orders of magnitude, R(sub eff) was similar to the preeruption value of 4.2 micrometers, because both small (r less than 0.25 micrometers) and large (r greater than 0.6 micrometers) particles increased in number, Over the next 3-6 months, R(sub eff) increased rapidly to about 0.5 micrometers. In general, R(sub eff) continued to increase for about a year after the eruption. The peak wavelength of optical depth spectra increased from initial values of less than 0.42 micrometers to values between 0.78 and 1 micrometer. This coupled evolution in particle size distribution and optical depth spectra helps explain the relationship between the global maps of 0.5 and 1.0-micrometer optical depth derived from the AVHRR and SAGE satellite measurements. It also sets a context for evaluating remaining uncertainties in each of these satellite data products. We also make consensus recommendations for particle composition, shape, and temperature- and wavelength-dependent refractive index, and show how the latter effect on backscatter spectra can influence particle sizes retrieved from multiwavelength lidar measurements.
    Keywords: Environment Pollution
    Type: 21st General Assembly; Jul 02, 1995 - Jul 14, 1995; Boulder, CO; United States
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  • 9
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    A Unified Picture of Pinatubo Aerosol Global-to Micro-Scale Evolution, From Space, Air, and Ground Measurements (1995)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: We combine a variety of measurements to develop a composite picture of the post-Pinatubo aerosol and assess the consistency and uncertainties of the measurement and retrieval techniques. Satellite infrared spectroscopy, particle morphology, and evaporation temperature measurements are in accord with theoretical calculations in showing a dominant particle composition of H2SO4-H2O mixture, with H2SO4 weight fraction of 65-80% for most stratospheric temperatures and humidities. Important exceptions are: (1) the presence of volcanic ash at all altitudes initially and in a layer just above the tropopause until at least March 1992, and (2) much smaller H2SO4 weight fractions at the low temperatures attained in high latitude winters and at the tropical tropopause, Laboratory spectroscopy and theoretical calculations yield wavelength- and temperature-dependent refractive indices for the dominant H2SO4-H2O droplets. These in turn permit derivation of particle size spectra from measured optical depth spectra, for comparison to direct measurements by impactors and optical counters. All three techniques paint a generally consistent picture of the evolution of R(sub eff), the effective, or area-weighted, particle radius. In the first month after the eruption, although particle numbers increased by orders of magnitude, R(sub eff) was similar to the preemption value of 0.1 to 0.2 microns, because both small (r less than 0.2 microns) and large (r greater than 0.6 micron particles increased in number. Over the next 3-6 months, R(sub eff) increased to about 0.5 microns reflecting particle growth through condensation and coagulation. In general, R(sub eff) continued to increase for about a year after the eruption. Extinction spectra computed from in situ size distribution measurements are consistent with optical depth measurements, which show spectra with maxima initially at wavelengths of 0.42 microns or less, and thereafter progressively increasing to between 0.78 and 1 micron. Not until 1993 do optical depth spectra begin to show a clear return to the preemption signature of maximizing at the shortest visible wavelengths or in the near UV. This coupled evolution in particle size distribution and optical depth spectra helps explain the relationship between the global maps of 0.5- 1.0- micron optical depth derived from the AVHRR and SAGE satellite measurements.
    Keywords: Environment Pollution
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  • 10
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    A Statistical Study of the Global Structure of the Ring Current (1997)
    In:  CASI
    Details
    Publication Date: 2019-08-17
    Description: In this paper we derive the average configuration of the ring current as a function of the state of the magnetosphere as indicated by the Dst index. We sort magnetic field data from the Combined Release and Radiation Effects Satellite (CRRES) by spatial location and by the Dst index in order to produce magnetic field maps. From these maps we calculate local current systems by taking the curl of the magnetic field. NN7e find both the westward (outer) and the eastward (inner) components of the ring current. We find that the ring current intensity varies linearly with D.St as expected, and that the ring current is asymmetric for all Dst values. The azimuthal peak of the ring current is located in the afternoon sector for quiet conditions, and near midnight for disturbed conditions. The ring current also moves closer to the Earth during disturbed conditions. We are able to recreate the Dst index by integrating the magnetic perturbations caused by the ring current. We find that we needed to apply a 20 nT offset to Dst, and assume a perfectly conducting Earth to obtain an optimal agreement between the computed and the observed Dst. We interpret the 20 nT offset as the magnetic field generated by the quiet time ring current used as baseline in computing Dst.
    Keywords: Geophysics
    Format: application/pdf
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