ISSN:
1573-3904
Keywords:
7-aza-1-hydroxy-1,2,3-benzotriazole
;
desmotropy, 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine
;
1-hydroxy-1,2,3-benzotriazole
;
regiospecificity
;
X-ray crystallography
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary X-ray diffraction structure determinations of HOAt and HOOBt, two well-known additives for peptide bond formation, are reported in conjunction with those of seven derivatives of HOBt, HOAt, and HOOBt, five of which originate from Nα-protected α-amino acids. In the crystal state the two additives are found in the 1-hydroxy tautomeric form. In contrast to six derivatives which crystallize as esters, one, Fmoc-(N)OBt, is observed in the isomeric amide-type (urethane) form.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02443541
Permalink