Publication Date:
1997-10-24
Description:
BAD is a distant member of the Bcl-2 family that promotes cell death. Phosphorylation of BAD prevents this. BAD phosphorylation induced by interleukin-3 (IL-3) was inhibited by specific inhibitors of phosphoinositide 3-kinase (PI 3-kinase). Akt, a survival-promoting serine-threonine protein kinase, was activated by IL-3 in a PI 3-kinase-dependent manner. Active, but not inactive, forms of Akt were found to phosphorylate BAD in vivo and in vitro at the same residues that are phosphorylated in response to IL-3. Thus, the proapoptotic function of BAD is regulated by the PI 3-kinase-Akt pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉del Peso, L -- Gonzalez-Garcia, M -- Page, C -- Herrera, R -- Nunez, G -- CA-64556/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Oct 24;278(5338):687-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9381178" target="_blank"〉PubMed〈/a〉
Keywords:
Androstadienes/pharmacology
;
Animals
;
Apoptosis
;
Carrier Proteins/*metabolism
;
Cell Line
;
Chromones/pharmacology
;
Enzyme Activation
;
Enzyme Inhibitors/pharmacology
;
Humans
;
Interleukin-3/*pharmacology
;
Mice
;
Morpholines/pharmacology
;
Phosphatidylinositol 3-Kinases/antagonists & inhibitors/*metabolism
;
Phosphorylation
;
Phosphoserine/metabolism
;
Protein-Serine-Threonine Kinases/*metabolism
;
Proto-Oncogene Proteins/*metabolism
;
Proto-Oncogene Proteins c-akt
;
Proto-Oncogene Proteins c-bcl-2/metabolism
;
Recombinant Proteins/metabolism
;
Signal Transduction
;
bcl-Associated Death Protein
;
bcl-X Protein
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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