ISSN:
1432-0983
Keywords:
Key words Chromatin
;
Suppression
;
Yeast
;
Transcription elongation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Sequence analysis of a DNA fragment containing the KlCOX18 gene originating from chromosome II of the yeast Kluyveromyces lactis revealed the presence of an adjacent open reading frame (ORF) for a protein exhibiting 78.4% identity with the Saccharomyces cerevisiae Spt4p. Based on the identical length (102 aa) and the conservation of the zinc-finger motif found in Spt4p we named this ORF KlSPT4. When expressed in S. cerevisiae the KlSPT4 gene complemented all spt4 mutant phenotypes. It is proposed that KlSpt4p, like its S. cerevisiae counterpart is a protein involved in the establishment or maintenance of the chromatin structure that influences the expression of many yeast genes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002940050409
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