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  • Animals  (19)
  • Life Sciences (General)  (15)
  • *Anaphase
  • 1995-1999  (27)
  • 1980-1984  (8)
  • 11
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    A system for low field imaging of laser-polarized noble gas (1999)
    In:  Other Sources
    Details
    Publikationsdatum: 2011-08-24
    Beschreibung: We describe a device for performing MRI with laser-polarized noble gas at low magnetic fields (〈50 G). The system is robust, portable, inexpensive, and provides gas-phase imaging resolution comparable to that of high field clinical instruments. At 20.6 G, we have imaged laser-polarized (3)He (Larmor frequency of 67 kHz) in both sealed glass cells and excised rat lungs, using approximately 0.1 G/cm gradients to achieve approximately 1 mm(2) resolution. In addition, we measured (3)He T(2)(*) times greater than 100 ms in excised rat lungs, which is roughly 20 times longer than typical values observed at high ( approximately 2 T) fields. We include a discussion of the practical considerations for working at low magnetic fields and conclude with evidence of radiation damping in this system. Copyright 1999 Academic Press.
    Schlagwort(e): Life Sciences (General)
    Materialart: Journal of magnetic resonance (San Diego, Calif. : 1997) (ISSN 1090-7807); Volume 141; 2; 217-27
    Format: text
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  • 12
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    Low-field MRI of laser polarized noble gas (1998)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: NMR images of laser polarized 3He gas were obtained at 21 G using a simple, homebuilt instrument. At such low fields magnetic resonance imaging (MRI) of thermally polarized samples (e.g., water) is not practical. Low-field noble gas MRI has novel scientific, engineering, and medical applications. Examples include portable systems for diagnosis of lung disease, as well as imaging of voids in porous media and within metallic systems.
    Schlagwort(e): Life Sciences (General)
    Materialart: Physical review letters (ISSN 0031-9007); 81; 17; 3785-8
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 13
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    Myogenic regulatory factors during regeneration of skeletal muscle in young, adult, and old rats (1997)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: Myogenic factor mRNA expression was examined during muscle regeneration after bupivacaine injection in Fischer 344/Brown Norway F1 rats aged 3, 18, and 31 mo of age (young, adult, and old, respectively). Mass of the tibialis anterior muscle in the young rats had recovered to control values by 21 days postbupivacaine injection but in adult and old rats remained 40% less than that of contralateral controls at 21 and 28 days of recovery. During muscle regeneration, myogenin mRNA was significantly increased in muscles of young, adult, and old rats 5 days after bupivacaine injection. Subsequently, myogenin mRNA levels in young rat muscle decreased to postinjection control values by day 21 but did not return to control values in 28-day regenerating muscles of adult and old rats. The expression of MyoD mRNA was also increased in muscles at day 5 of regeneration in young, adult, and old rats, decreased to control levels by day 14 in young and adult rats, and remained elevated in the old rats for 28 days. In summary, either a diminished ability to downregulate myogenin and MyoD mRNAs in regenerating muscle occurs in old rat muscles, or the continuing myogenic effort includes elevated expression of these mRNAs.
    Schlagwort(e): Life Sciences (General)
    Materialart: Journal of applied physiology (Bethesda, Md. : 1985) (ISSN 8750-7587); 83; 4; 1270-5
    Format: text
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  • 14
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    Prospects for in utero human gene therapy (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999-10-16
    Beschreibung: Gene therapy for the treatment of disease in children and adults is being actively pursued at many medical centers. However, a number of genetic disorders result in irreversible damage to the fetus before birth. In these cases, as well as for those with genetic diseases who may benefit from therapy before symptoms are manifested, in utero gene therapy (IUGT) could be beneficial. Although some successes with in utero gene transfer have been reported in animals, significant questions remain to be answered before IUGT clinical trials would be acceptable. This review analyzes the state of the art and delineates the studies that still need to be performed before it would be appropriate to consider human IUGT.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zanjani, E D -- Anderson, W F -- New York, N.Y. -- Science. 1999 Sep 24;285(5436):2084-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Veterans Administration Medical Center, University of Nevada, Reno, NV 89520, USA. zanjani@scs.unr.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10523208" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Female ; Fetal Diseases/*therapy ; *Fetus ; Gene Transfer Techniques ; Genetic Diseases, Inborn/*therapy ; *Genetic Therapy/adverse effects ; Genetic Vectors ; Germ Cells ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/cytology/physiology ; Humans ; Pregnancy
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 15
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    Phylogenetic classification and the universal tree (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999-06-26
    Beschreibung: From comparative analyses of the nucleotide sequences of genes encoding ribosomal RNAs and several proteins, molecular phylogeneticists have constructed a "universal tree of life," taking it as the basis for a "natural" hierarchical classification of all living things. Although confidence in some of the tree's early branches has recently been shaken, new approaches could still resolve many methodological uncertainties. More challenging is evidence that most archaeal and bacterial genomes (and the inferred ancestral eukaryotic nuclear genome) contain genes from multiple sources. If "chimerism" or "lateral gene transfer" cannot be dismissed as trivial in extent or limited to special categories of genes, then no hierarchical universal classification can be taken as natural. Molecular phylogeneticists will have failed to find the "true tree," not because their methods are inadequate or because they have chosen the wrong genes, but because the history of life cannot properly be represented as a tree. However, taxonomies based on molecular sequences will remain indispensable, and understanding of the evolutionary process will ultimately be enriched, not impoverished.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doolittle, W F -- New York, N.Y. -- Science. 1999 Jun 25;284(5423):2124-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Canadian Institute for Advanced Research, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada. ford@is.dal.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10381871" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Archaea/*classification/genetics ; Bacteria/*classification/genetics ; *Biological Evolution ; Eukaryotic Cells/*classification ; Genes, rRNA ; Genome ; *Phylogeny ; RNA, Ribosomal/chemistry/genetics ; *Recombination, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 16
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    Biospherian viewpoints (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-02-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dempster, W F -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1247-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9064774" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arizona ; Atmosphere ; *Ecological Systems, Closed ; *Ecosystem ; Humans
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 17
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    Mitosis in living budding yeast: anaphase A but no metaphase plate (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-07-25
    Beschreibung: Chromosome movements and spindle dynamics were visualized in living cells of the budding yeast Saccharomyces cerevisiae. Individual chromosomal loci were detected by expression of a protein fusion between green fluorescent protein (GFP) and the Lac repressor, which bound to an array of Lac operator binding sites integrated into the chromosome. Spindle microtubules were detected by expression of a protein fusion between GFP and Tub1, the major alpha tubulin. Spindle elongation and chromosome separation exhibited biphasic kinetics, and centromeres separated before telomeres. Budding yeast did not exhibit a conventional metaphase chromosome alignment but did show anaphase A, movement of the chromosomes to the poles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Straight, A F -- Marshall, W F -- Sedat, J W -- Murray, A W -- New York, N.Y. -- Science. 1997 Jul 25;277(5325):574-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Box 0444, School of Medicine, University of California at San Francisco, San Francisco, CA 94143-0444, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9228009" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Anaphase ; Bacterial Proteins/metabolism ; Centromere/chemistry/physiology ; Chromatids/physiology ; Chromosomes, Fungal/chemistry/*physiology ; *Escherichia coli Proteins ; Green Fluorescent Proteins ; Lac Repressors ; Luminescent Proteins ; *Metaphase ; Microscopy, Fluorescence ; Microtubules/ultrastructure ; *Mitosis ; Movement ; Operator Regions, Genetic ; Recombinant Fusion Proteins ; Repressor Proteins/metabolism ; Saccharomyces cerevisiae/*cytology ; Spindle Apparatus/physiology/ultrastructure ; Telomere/physiology ; Tubulin/analysis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 18
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    Prevention of vascular and neural dysfunction in diabetic rats by C-peptide (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-07-25
    Beschreibung: C-peptide, a cleavage product from the processing of proinsulin to insulin, has been considered to possess little if any biological activity other than its participation in insulin synthesis. Injection of human C-peptide prevented or attenuated vascular and neural (electrophysiological) dysfunction and impaired Na+- and K+-dependent adenosine triphosphate activity in tissues of diabetic rats. Nonpolar amino acids in the midportion of the peptide were required for these biological effects. Synthetic reverse sequence (retro) and all-D-amino acid (enantio) C-peptides were equipotent to native C-peptide, which indicates that the effects of C-peptide on diabetic vascular and neural dysfunction were mediated by nonchiral interactions instead of stereospecific receptors or binding sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ido, Y -- Vindigni, A -- Chang, K -- Stramm, L -- Chance, R -- Heath, W F -- DiMarchi, R D -- Di Cera, E -- Williamson, J R -- EY 06600/EY/NEI NIH HHS/ -- HL 39934/HL/NHLBI NIH HHS/ -- HL 58141/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 Jul 25;277(5325):563-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9228006" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Blood Circulation/drug effects ; Blood Glucose/metabolism ; C-Peptide/*chemistry/pharmacology/*therapeutic use ; Capillary Permeability/drug effects ; Circular Dichroism ; Diabetes Mellitus, Experimental/drug therapy/physiopathology ; Diabetic Angiopathies/*prevention & control ; Diabetic Neuropathies/*prevention & control ; Humans ; Male ; Molecular Sequence Data ; Neural Conduction/drug effects ; Peptide Fragments/pharmacology ; Protein Structure, Secondary ; Rats ; Rats, Sprague-Dawley ; Sodium-Potassium-Exchanging ATPase/metabolism ; Stereoisomerism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 19
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    Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-03
    Beschreibung: The vascular complications of diabetes mellitus have been correlated with enhanced activation of protein kinase C (PKC). LY333531, a specific inhibitor of the beta isoform of PKC, was synthesized and was shown to be a competitive reversible inhibitor of PKC beta 1 and beta 2, with a half-maximal inhibitory constant of approximately 5 nM; this value was one-fiftieth of that for other PKC isoenzymes and one-thousandth of that for non-PKC kinases. When administered orally, LY333531 ameliorated the glomerular filtration rate, albumin excretion rate, and retinal circulation in diabetic rats in a dose-responsive manner, in parallel with its inhibition of PKC activities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ishii, H -- Jirousek, M R -- Koya, D -- Takagi, C -- Xia, P -- Clermont, A -- Bursell, S E -- Kern, T S -- Ballas, L M -- Heath, W F -- Stramm, L E -- Feener, E P -- King, G L -- DK36836/DK/NIDDK NIH HHS/ -- EY05110-11/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1996 May 3;272(5262):728-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8614835" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Administration, Oral ; Albuminuria/prevention & control ; Animals ; Diabetes Mellitus, Experimental/*complications/enzymology/physiopathology ; Diabetic Angiopathies/enzymology/etiology/*prevention & control ; Diglycerides/metabolism ; Dose-Response Relationship, Drug ; Enzyme Activation ; Enzyme Inhibitors/chemistry/*pharmacology ; Glomerular Filtration Rate/drug effects ; Humans ; Indoles/administration & dosage/chemistry/*pharmacology ; Isoenzymes/*antagonists & inhibitors/metabolism ; Kidney Glomerulus/metabolism ; Male ; Maleimides/administration & dosage/chemistry/*pharmacology ; Muscle, Smooth, Vascular/enzymology ; Phosphorylation/drug effects ; Protein Kinase C/*antagonists & inhibitors/metabolism ; Protein Kinase C beta ; Rats ; Rats, Sprague-Dawley ; Regional Blood Flow/drug effects ; Renal Plasma Flow/drug effects ; Retina/metabolism ; Retinal Vessels/physiopathology ; Substrate Specificity
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 20
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    Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-02-16
    Beschreibung: The genetic background of T lymphocytes influences development of the T helper (TH) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells to interleukin-12 (IL-12) was detected between BALB/c and B10.D2 mice. Although naive T cells from both strains initially responded to IL-12, BALB/c T cells lost IL-12 responsiveness after stimulation with antigen in vitro, even when cocultured with B10.D2 T cells. Thus, susceptibility of BALB/c mice to infection with L. major may derive from the loss of the ability to generate IL-12-induced TH1 responses rather than from an IL-4-induced TH2 response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guler, M L -- Gorham, J D -- Hsieh, C S -- Mackey, A J -- Steen, R G -- Dietrich, W F -- Murphy, K M -- AI31238/AI/NIAID NIH HHS/ -- AI34580/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1996 Feb 16;271(5251):984-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8584935" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cells, Cultured ; Coculture Techniques ; Genetic Predisposition to Disease ; Immunity, Innate/genetics ; Interferon-gamma/biosynthesis ; Interleukin-12/*pharmacology ; Interleukin-4/biosynthesis ; Leishmania major/*immunology ; Leishmaniasis, Cutaneous/*immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Phenotype ; Receptors, Interleukin-2/biosynthesis ; Signal Transduction ; Th1 Cells/*immunology ; Th2 Cells/immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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