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  • 1995-1999  (73)
  • 1990-1994  (84)
  • 1
    Electronic Resource
    Electronic Resource
    Application of 6 MeV/n heavy-ion beams to biophysical experiments (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 2000-2004 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A new accelerator facility and two irradiation methods using 6 MeV/n heavy-ion beams are described along with preliminary results concerning their applications to biophysical investigations. The beams are obtained from the injector linac installed at the Heavy Ion Medical Accelerator in Chiba. Various ion species (He–Xe) having different charge states are accelerated to the same velocity, which is suitable for comparing the charge effects of heavy ions in the high linear energy transfer region. An attempt has been made to test the usefulness of the apparatus for studying track structure by using pBR322 plasmid DNA and spores as targets in vacuum. Newly constructed equipment with a molecular-beam source (water vapor) placed on this beam line is also described. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1146958
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  • 2
    Electronic Resource
    Electronic Resource
    Development of the National Institute of Radiological Sciences electron cyclotron resonance ion source for the heavy ion medical accelerator in Chiba : Proceedings of the 5th international conference on ion sources (1994)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 65 (1994), S. 1087-1089 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The development of an electron cyclotron resonance ion source for the heavy ion medical accelerator in Chiba (HIMAC) injector is reported. The HIMAC is a heavy ion medical accelerator for cancer therapy. The electron cyclotron resonance (ECR) ion source is expected to provide a long lifetime, easy operation, and easy maintenance for medical use. The NIRS-ECR ion source has a single closed ECR stage, and a microwave frequency of 10 GHz is applied. Under the present performance, the output electrical currents of the ions are 2500 eμA for He1+, 300 eμA for C2+, 480 eμA for Ne3+, and 110 eμA for Ar6+. Stability of the intensity is better than 2%. The transmission efficiency through a low-energy beam-transport line with an acceptance of 200 πmm mrad is more than 70%; the typical 50% and 90% emittances of the injection beam with 8 keV/u are 20 and 80 πmm mrad, respectively. These performances satisfy the requirements for radiotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1145071
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  • 3
    Electronic Resource
    Electronic Resource
    Study of crystallographic orientations in the diamond film on cubic boron nitride using Raman microprobe (1990)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 57 (1990), S. 428-431 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have measured Raman spectra of a diamond film prepared on the (111) surface of cubic boron nitride(c-BN) by the dc plasma chemical vapor deposition method. The polarization property of the Raman line of diamond agrees well with that of LO phonon for the (111) surface of c-BN. The agreement between the polarization property of Raman lines of diamond and c-BN indicates a possibility of the heteroepitaxial growth of the diamond film on the (111) surface of c-BN. It is found that the diamond layers on c-BN are under tensile stress of 2.2×1011 dyn/cm2. The value of the corresponding tensile strain agrees well with the lattice mismatch calculated from the lattice constants of c-BN and diamond, supporting the possibility of the heteroepitaxial growth of the diamond film. Raman spectroscopy is a powerful technique not only to estimate the stress in the diamond film but also to determine the crystallographic orientation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.103656
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  • 4
    Electronic Resource
    Electronic Resource
    Epitaxial growth of diamond thin films on cubic boron nitride {111} surfaces by dc plasma chemical vapor deposition (1990)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 57 (1990), S. 563-565 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Diamond thin films have been grown epitaxially on high-pressure synthesized cubic boron nitride (c-BN) particles by using dc plasma chemical vapor deposition. At the early growth stage of the film on c-BN{111} surfaces, the island structure is observed and the number density of islands is about 1011 cm−2. The growth and the coalescence of islands are also found by scanning electron microscopy observation. The continuous film is obtained at the thickness of about 2000 A(ring) and the surface of the film is rather smooth. The Raman peak of the epitaxial diamond film shows the shift toward the lower wave number due to the tensile stress involved in the film.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.103647
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemical Localization of the Proteins Associated with Brain N-Type Calcium Channels (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 707 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb38075.x
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  • 6
    Electronic Resource
    Electronic Resource
    Global changes in gene expression related to antibiotic synthesis in Streptomyces hygroscopicus (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 6 (1992), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Two-dimensional gel electrophoresis was used to follow low changes in gene expression associated with antibiotic (bialaphos) biosynthesis in Streptomyces hygroscopicus. Cultures were pulse-labelled with [35S]-methionine before, during, and after the switch from primary to secondary metabolism in order to compare kinetic profiles of bialaphos (antibiotic) production (bap) genes during this metabolic transition. Separation of gene products on two-dimensional gels revealed that 27 were dependent on brpA for optimal expression and were activated as the culture approached stationary phase. Genes which encoded 10 brp4-dependent proteins were mapped to a 10 kb Sstl fragment of the 35 kb bap gene cluster by expressing them in Streptomyces lividans using the thiostrepton-inducible tipA promoter. N-terminal amino acid sequences of two brpA-dependent proteins, obtained by direct microsequencing of protein spots excised from two-dimensional gels, identified them as gene products mapping to the same region and involved in secondary metabolic conversions of the bap pathway. The kinetics of synthesis of 16 brpA-dependent gene products were characterized using QUEST computer software. Cluster analysis performed on the kinetics of synthesis of 346 of the most highly expressed gene products of HP5-29, including 16 brpA-dependent ones, identified 75 families having distinct patterns of expression. Many brpA-dependent proteins were clustered together; 10 were found in one kinetic family. These kinetic families also included brpA-independent gene products perhaps subject to similar regulatory mechanisms and thus possibly involved in bialaphos biosynthesis. The activation/derepression of bap expression took place as cultures approached stationary phase and was temporally related to synthesis of ppGpp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1992.tb02163.x
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  • 7
    Electronic Resource
    Electronic Resource
    Localization of a gene for Fukuyama type congenital muscular dystrophy to chromosome 9q31–33 (1993)
    [s.l.] : Nature Publishing Group
    Nature genetics 5 (1993), S. 283-286 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Fukuyama type congenital muscular dystrophy (FCMD) is an autosomal recessive severe muscular dystrophy associated with an anomaly of the brain. Twenty–one FCMD families, 13 of them with consanguineous marriages, were analysed by genetic linkage analyses with polymorphic microsatellite markers ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1193-283
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  • 8
    Electronic Resource
    Electronic Resource
    Mercury levels and its chemical form in tissues and organs of seabirds (1996)
    Springer
    Archives of environmental contamination and toxicology 30 (1996), S. 259-266 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Liver, muscle, kidney, and feather samples from nine species of seabirds were analyzed for total and organic (methyl) mercury (MM). Total mercury (TM) levels in liver showed great intra- and inter-species variations, with the concentrations varied from 306 μg/g (dry weight) in black-footed albatross (Diomedea nigripes) to 4.9 μg/g in arctic tern (Sterna paradisaea), while MM levels were less relatively variable. The order of MM concentrations in tissues of all the seabirds except oldsquaw (Clangula hyemalis) was as follows: liver 〉 kidney 〉 muscle. The mean percentage of MM in total was 35%, 36%, and 66% in liver, kidney, and muscle, respectively, for all the species. Statistically significant negative correlations were found between the proportion of MM to TM and concentrations of TM in the liver and muscle of black-footed albatross and in the liver of laysan albatross. Furthermore, the percentage of MM decreased with an increase in TM concentrations in the liver, muscle, and kidney of all the species. Black-footed albatross had the highest concentration and burden of mercury in the liver, wherein more than 70% of the TM occurred as inorganic mercury. On the other hand, the mercury burdens in feathers were less than 10% of the body burdens, indicating that excretion of mercury by moulting is negligible. The results suggest that some seabirds are capable of demethylating MM in the tissues (mainly in liver), and store mercury as an immobilizable inorganic form in the liver. It is noteworthy that the species with a high degree of demethylation capacity and slow moulting pattern showed low mercury burdens in feathers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215806
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  • 9
    Electronic Resource
    Electronic Resource
    Mercury Levels and its Chemical Form in Tissues and Organs of Seabirds (1996)
    Springer
    Archives of environmental contamination and toxicology 30 (1996), S. 259-266 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. Liver, muscle, kidney, and feather samples from nine species of seabirds were analyzed for total and organic (methyl) mercury (MM). Total mercury (TM) levels in liver showed great intra- and inter-species variations, with the concentrations varied from 306 μg/g (dry weight) in black-footed albatross (Diomedea nigripes) to 4.9 μg/g in arctic tern (Sterna paradisaea), while MM levels were less relatively variable. The order of MM concentrations in tissues of all the seabirds except oldsquaw (Clangula hyemalis) was as follows: liver〉 kidney〉 muscle. The mean percentage of MM in total was 35%, 36%, and 66% in liver, kidney, and muscle, respectively, for all the species. Statistically significant negative correlations were found between the proportion of MM to TM and concentrations of TM in the liver and muscle of black-footed albatross and in the liver of laysan albatross. Furthermore, the percentage of MM decreased with an increase in TM concentrations in the liver, muscle, and kidney of all the species. Black-footed albatross had the highest concentration and burden of mercury in the liver, wherein more than 70% of the TM occurred as inorganic mercury. On the other hand, the mercury burdens in feathers were less than 10% of the body burdens, indicating that excretion of mercury by moulting is negligible. The results suggest that some seabirds are capable of demethylating MM in the tissues (mainly in liver), and store mercury as an immobilizable inorganic form in the liver. It is noteworthy that the species with a high degree of demethylation capacity and slow moulting pattern showed low mercury burdens in feathers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215806
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  • 10
    Electronic Resource
    Electronic Resource
    X-ray identification of the soft γ-ray repeater 1806 – 20 (1994)
    [s.l.] : Nature Publishing Group
    Nature 368 (1994), S. 127-129 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] On 29 September 1993, the Burst And Transient Source Experiment (BATSE) team discovered that SGR 1806-20 became burst-active again11 after almost a decade since the last activity was observed4. This motivated us to conduct observations with ASCA for 2 days, from 16:05 UT on 9 October to 14:35uT on ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/368127a0
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