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  • Articles  (596)
  • 1995-1999  (596)
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  • 1
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    Requirement for the adapter protein GRB2 in EGF receptor endocytosis (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-28
    Description: Activated epidermal growth factor (EGF) receptors induce the formation of various complexes of intracellular signaling proteins that are mediated by SRC homology 2 (SH2) and SH3 domains. The activated receptors are also rapidly internalized into the endocytotic compartment and degraded in lysosomes. EGF stimulation of canine epithelial cells induced a rapid and transient association of the SH3-SH2-SH3 protein GRB2 with dynamin, a guanosine triphosphatase that regulates endocytosis. Disruption of GRB2 interactions by microinjection of a peptide corresponding to the GRB2 SH2 domain or its phosphopeptide ligand blocked EGF receptor endocytosis; other SH2 domains that bind EGF receptors or antibodies that neutralize RAS did not. Both activation and termination of EGF signaling appear to be regulated by the diverse interactions of GRB2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Z -- Moran, M F -- New York, N.Y. -- Science. 1996 Jun 28;272(5270):1935-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Banting and Best Department of Medical Research, University of Toronto, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658166" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptor Proteins, Signal Transducing ; Animals ; Antibodies, Monoclonal ; Cell Line ; Dogs ; Dynamins ; *Endocytosis/drug effects ; Epidermal Growth Factor/pharmacology ; GRB2 Adaptor Protein ; GTP Phosphohydrolases/metabolism ; Microinjections ; Peptide Fragments/pharmacology ; Proteins/*metabolism ; Receptor, Epidermal Growth Factor/*metabolism ; Receptors, Transferrin/metabolism ; Recombinant Fusion Proteins/pharmacology ; Signal Transduction ; ras Proteins/immunology/physiology ; src Homology Domains/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-31
    Description: CHOP, a member of the C/EBP family of transcription factors, mediates effects of cellular stress on growth and differentiation. It accumulates under conditions of stress and undergoes inducible phosphorylation on two adjacent serine residues (78 and 81). In vitro, CHOP is phosphorylated on these residues by p38 mitogen-activated protein kinase (MAP kinase). A specific inhibitor of p38 MAP kinase, SB203580, abolished the stress-inducible in vivo phosphorylation of CHOP. Phosphorylation of CHOP on these residues enhanced its ability to function as a transcriptional activator and was also required for the full inhibitory effect of CHOP on adipose cell differentiation. CHOP thus serves as a link between a specific stress-activated protein kinase, p38, and cellular growth and differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, X Z -- Ron, D -- New York, N.Y. -- Science. 1996 May 31;272(5266):1347-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 10016, NY, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650547" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Adipocytes/cytology ; Amino Acid Sequence ; Animals ; *CCAAT-Enhancer-Binding Proteins ; Calcium-Calmodulin-Dependent Protein Kinases/*metabolism ; Cell Differentiation ; Cell Division ; Culture Media ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; Enzyme Inhibitors/pharmacology ; Imidazoles/pharmacology ; Methyl Methanesulfonate/pharmacology ; Mice ; *Mitogen-Activated Protein Kinases ; Molecular Sequence Data ; Phosphorylation ; Pyridines/pharmacology ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Transcription Factor CHOP ; Transcription Factors/chemistry/genetics/*metabolism ; Transcriptional Activation ; p38 Mitogen-Activated Protein Kinases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Absorption and Raman spectra of Se8-ring clusters in zeolite 5A (1996)
    Elsevier
    Details
    Publication Date: 1996-12-01
    Print ISSN: 0038-1098
    Electronic ISSN: 1879-2766
    Topics: Physics
    Published by Elsevier
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  • 4
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    Ecology of newly formed sea ice in the Weddell Sea, Antarctica I. Chlorophyll a and nutrients (1997)
    In:  EPIC3Chinese J Polar Sci, 8(1), pp. 18-26
    Details
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
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  • 5
    Electronic Resource
    Electronic Resource
    Connection between corner vortices and shear layer instability in flow past an ellipse (1999)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 11 (1999), S. 2446-2448 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We investigate, by numerical simulation, the shear layer instability associated with the outer layer of a spiral vortex formed behind an impulsively started thin ellipse. The unstable free shear layer undergoes a secondary instability. We connect this instability with the dynamics of corner vortices adjacent to the tip of the ellipse by observing that the typical turnover time of the corner vortex matches the period of the unstable mode in the shear layer. We suggest that the corner vortex acts as a signal generator, and produces periodic perturbation which triggers the instability. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.870108
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  • 6
    Electronic Resource
    Electronic Resource
    Raman scattering in hexagonal GaN epitaxial layer grown on MgAl2O4 substrate (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 2051-2054 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The room temperature Raman spectra of the hexagonal GaN epilayer grown on [111]- oriented MgAl2O4 substrate were measured in various backscattering and right angle scattering geometries. All of the symmetry—allowed optical phonon modes were observed except the E2 (low frequency) mode. The quasitransverse and quasilongitudinal modes were also observed in the x(zx)z and x(yy)z configurations, which are the mixed modes of pure transverse and longitudinal modes with A1 and E1 symmetry, respectively. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.371007
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  • 7
    Electronic Resource
    Electronic Resource
    Performance analysis of the commissioning filter and window assembly for insertion device beamlines at the Advanced Photon Source : The 9th National conference on synchrotron radiation instrumentation (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 3375-3376 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Although the Advanced Photon Source (APS) undulator beamlines are designed for windowless operation, a special window assembly will be used during the commissioning phase of the beamlines until sufficient operational experience is gained with the powerful undulator A photon beam. This assembly is called a "commissioning window.'' The commissioning window assembly as designed consists of a 300-μm-thick filter (made of graphite), a fixed mask (made of Glidcop), a multipurpose transmitting filter/BPM disk (made of 127-μm-thick CVD diamond), and set of a double windows (made of 250-μm-thick beryllium). Due to the high total power and power density, the filter/window assembly must be carefully designed to guarantee longevity and satisfactory performance throughout its service. Hence extensive analytical work has been conducted on various thermal and structural aspects of the commissioning window assembly. This paper summarizes the analytical results and presents the expected performance characteristics of the as-designed commissioning window. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1147516
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  • 8
    Electronic Resource
    Electronic Resource
    Two-dimensional toroidal electron analyzer for energy and angular dispersive measurements (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 1970-1977 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A toroidal electrostatic analyzer with a two-dimensional position-sensitive electron detector has been developed for the measurement of differential excitation cross sections in electron-ion collisions. The electron position is resolved simultaneously in the energy and angular dispersive directions of the analyzer. The present electron analyzer is specially designed with a narrow curved entrance slit and a wide exit slit coupled with an exit lens system after the toroidal deflector, which can give a wide energy dispersed range of 20% of the mean pass energy and a large angular range extending from 30° to 120°. The performance of the spectrometer has been studied by measuring the scattered electrons from Ar atoms and from a highly oriented pyrolytic graphite surface, indicating the usefulness of the present analyzer in electron spectroscopy. A brief description of the method for a spectrum transformation from Cartesian coordinates to polar coordinates is also presented. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149696
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  • 9
    Electronic Resource
    Electronic Resource
    Off-line efficiency measurements of the microwave discharge source (MIDAS) at the Laboratorio Nazionale del Sud : Proceedings of the 7th international conference on ion sources (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 747-749 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The aim of the EXCYT project at the Laboratorio Nazionale del Sud (LNS) is the production of radioactive beams, and for this we need to carry out the ionization of recoils produced in a target with as high an efficiency as possible. In order to obtain efficient positive ionization the microwave discharge ion source (MIDAS) has been designed to be followed by a charge exchange canal. A prototype of this source has been designed, built, and tested at the LNS and a description of this source is presented in this article along with the preliminary results and a design of the final version. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1148564
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  • 10
    Electronic Resource
    Electronic Resource
    Recent progress in optical current sensing techniques (1995)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 3097-3111 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: This paper reviews recent developments in the field of current measurement which employ a wide range of optical and fiber optic techniques. Depending on the current sensing mechanisms involved and the sensing materials used, optical current sensors (OCSs) may be categorized into four main groups: (i) OCSs employing optical fiber as their sensing elements, (ii) OCSs using bulk glass to sense the current, (iii) OCSs using electro-optic hybrid sensing devices, and (iv) OCSs using magnetic field sensing devices. The operational modes of a variety of OCSs have been grouped and discussed, and several examples given. It can be seen that as a result of an intensive and wide ranging research effort using various approaches, substantial progress in the differing aspects of the optical current sensing techniques considered, such as the sensing material used, the configurations of sensing elements introduced, and the detection schemes adapted, has been achieved during the past years. An overall view of the field shows it to be as an active and exciting research area, highlighting several recently introduced and novel sensing materials and configurations which provide impressive results in this field of instrumentation. Examples of applications for the electric power industry are discussed more extensively. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1145537
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