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  • 1
    Electronic Resource
    Electronic Resource
    Spatial solitons in photorefractive Bi12TiO20 with drift mechanism of nonlinearity (1994)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 408-410 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The analysis performed shows that in cubic photorefractive crystals (of Bi12SiO20 and GaAs type in particular) with drift ("quasilocal'') mechanism of optical nonlinearity spatial soliton propagation can be observed for reasonable external dc electric fields 10–15 kV/cm. These photorefractive solitons which can be excited at very low cw laser power are stable in a broad region of signal(soliton)/incoherent(spatially uniform) intensity ratio, and allow easy switching from bright to dark type. Original experimental results of self-channeling of submicrowatt HeNe laser beam in a cubic Bi12TiO20 sample under external dc field are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.111163
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  • 2
    Electronic Resource
    Electronic Resource
    High Resolution Nmr Studies of Paniculine and Related Lycopodium Compounds (1990)
    s.l. : American Chemical Society
    Journal of natural products 53 (1990), S. 200-203 
    Details
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/np50067a032
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  • 3
    Electronic Resource
    Electronic Resource
    1α,5α-Dihydroxymanoyl Oxide, a Novel Diterpene from Satureja gilliesii (1997)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 624-626 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270197000048
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  • 4
    Electronic Resource
    Electronic Resource
    Acetylsaturejol, an endo-peroxide menthane derivative from Satureja gilliessi (1990)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 46 (1990), S. 802-804 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270189009649
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  • 5
    Electronic Resource
    Electronic Resource
    Self-focusing in photorefractive BaTiO3 crystal under external DC electric field (1998)
    Springer
    Optical and quantum electronics 30 (1998), S. 829-834 
    Details
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract Experimental observations of 1D and 2D self-focusing in a BaTiO3 crystal under externally DC applied electric field are reported. Stationary self-focusing behaviour can be obtained with and without additional uniform illumination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006930624765
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  • 6
    Electronic Resource
    Electronic Resource
    Methimazole treatment reduces cardiac hypertrophy and mortality without a concomitant reduction in blood pressure in established Goldblatt two-kidney one clip hypertension (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 755-758 
    Details
    ISSN: 1420-9071
    Keywords: Goldblatt two-kidney one clip hypertension ; methimazole ; hypothyroidism ; relative cardiac hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of methimazole, and antithyroid drug, on blood pressure and other parameters were evaluated in the established phase of Goldblatt two-kidney one clip (G2K-1C) hypertension. Methimazole was administered via drinking water for five weeks, starting five weeks after hypertension had been induced. After this period of treatment, similarly high blood pressures were observed in methimazole-treated and non-treated G2K-1C rats, despite the fact that a hypothyroid state had been achieved in methimazole-treated rats. Methimazole-treated G2K-1C rats showed reductions in heart rate, ventricular weight, ventricular/body weight ratio and mortality in comparison with rats not treated with methimazole. These results clearly demonstrate that hypothyroidism induced by methimazole: a) does not reverse G2K-1C hypertension, but b) improves the rate of survival and c) reduces relative cardiac hypertrophy, possibly by the reduction in cardiac work observed in Goldblatt hypothyroid rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02124296
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  • 7
    Electronic Resource
    Electronic Resource
    Determination of tungsten with pyrocatechol violet by first-derivative solid-phase spectrophotometry (1994)
    Springer
    Microchimica acta 112 (1994), S. 225-235 
    Details
    ISSN: 1436-5073
    Keywords: solid-phase spectrophotometry ; derivative spectrophotometry ; pyrocatechol violet ; tungsten determination ; natural and industrial waters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Derivative spectrophotometry was applied to solid-phase spectrophotometry in order to enhance its sensitivity and remove the large background caused by the absorbance of the resin layer. Determination of micro-amounts of tungsten with pyrocatechol violet to form a 2∶1 green complex in acid medium which is fixed on a dextran-type anion-exchange resin (Sephadex QAEA-25) is described as an example for the application of this technique. The absorbance of the resin packed in a 1-mm spectrophotometric cell, was measured directly. The characteristic peak amplitude of the signal at 674 nm in the first-derivative spectrum is useful for quantitative determination of tungsten (3–16 μg 1−1; RSD 5.8%) in natural and industrial water samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01242838
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  • 8
    Electronic Resource
    Electronic Resource
    Hb Costa Rica or α2β277(EF1)His→Arg: The first example of a somatic cell mutation in a globin gene (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 829-833 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have identified a minor hemoglobin component (∼5%) in the blood of a healthy Costa Rican female, but not in her mother and two brothers (father not studied), that has an His→Arg replacement at position β77 (Hb Costa Rica). No other amino acid replacements were observed and no β- or γ-chain-like peptides were present. Hb Costa Rica has a normal stability. Sequence analyses of numerous polymerase chain reaction (PCR)-amplified segments of DNA that contain exon 2 of the β gene failed to identify a CAC→WGC (His→Arg) mutation. The same was the case when cDNA was sequenced, indicating that a β-Costa Rica-mRNA could not be detected with this procedure. Gene mapping of genomic DNA withBglII,BamHI, andHindIII gave normal fragments only and with the same intensity as observed for the fragments of a normal control. The quantities of the β chain variants Hb JIran and Hb Fukuyama with related mutations at (β77 vary between 30% and 45% in heterozygotes, whereas that of Hb F-Kennestone with the same His→Arg mutation but in theGyγ-globin gene, is a high 40%–45% (as percentage of totalGγ) in a heterozygous newborn. These different observations exclude a heterozygosity of the A→G mutation at codon β77, as well as a deletion comparable to that of Hbs Lepore or Kenya, or a β-globin gene duplication, and point to a nontraditional inheritance of Hb Costa Rica. Allele-specific amplification of cDNA with appropriate primers identified the presence of a low level of mutated mRNA in the reticulocytes of the patient, which was confirmed by dotblot analysis of the same material with32p-labeled probes. Comparable amplification products were not observed in genomic DNA. The A→G mutation apparently occurred in a somatic cell at a relatively early stage in the development of the hematopoietic cell system, and Hb Costa Rica accumulated through rapid cell divisions in patchy areas in the bone marrow (somatic mosaicism). An unequal distribution of Hb Costa Rica over the red cells supports this possibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02346198
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  • 9
    Electronic Resource
    Electronic Resource
    Hb Costa Rica or · 2 ‚ 277(EF1)His→Arg: the first example of a somatic cell mutation in a globin gene (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 829-833 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have identified a minor hemoglobin component (∼5%) in the blood of a healthy Costa Rican female, but not in her mother and two brothers (father not studied), that has an His→Arg replacement at position β77 (Hb Costa Rica). No other amino acid replacements were observed and no β- or γ-chain-like peptides were present. Hb Costa Rica has a normal stability. Sequence analyses of numerous polymerase chain reaction (PCR)-amplified segments of DNA that contain exon 2 of the β gene failed to identify a CAC→CGC (His→Arg) mutation. The same was the case when cDNA was sequenced, indicating that a β-Costa Rica-mRNA could not be detected with this procedure. Gene mapping of genomic DNA with BglII, BamHI, and HindIII gave normal fragments only and with the same intensity as observed for the fragments of a normal control. The quantities of the β chain variants Hb J-Iran and Hb Fukuyama with related mutations at β77 vary between 30% and 45% in heterozygotes, whereas that of Hb F-Kennestone with the same His→Arg mutation but in the Gγ-globin gene, is a high 40%–45% (as percentage of total Gγ) in a heterozygous newborn. These different observations exclude a heterozygosity of the A→G mutation at codon β77, as well as a deletion comparable to that of Hbs Lepore or Kenya, or a β-globin gene duplication, and point to a nontraditional inheritance of Hb Costa Rica. Allele-specific amplification of cDNA with appropriate primers identified the presence of a low level of mutated mRNA in the reticulocytes of the patient, which was confirmed by dotblot analysis of the same material with 32P-labeled probes. Comparable amplification products were not observed in genomic DNA. The A→G mutation apparently occurred in a somatic cell at a relatively early stage in the development of the hematopoietic cell system, and Hb Costa Rica accumulated through rapid cell divisions in patchy areas in the bone marrow (somatic mosaicism). An unequal distribution of Hb Costa Rica over the red cells supports this possibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050145
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of phenylalanine derivatives on the main regulatory enzymes of hepatic cholesterogenesis (1991)
    Springer
    Molecular and cellular biochemistry 105 (1991), S. 21-25 
    Details
    ISSN: 1573-4919
    Keywords: cholesterogenesis ; phenylketonuria ; HMG-CoA reductase ; MVAPP decarboxylase ; phenylalanine-derivatives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Phenylalanine, phenylpyruvate and phenylacetate produced a considerable inhibition of chick liver mevalonate 5-pyrophosphate decarboxylase while mevalonate kinase and mevalonate 5-phosphate kinase were not significantly affected. Phenolic derivatives of phenylalanine produced a similar inhibition of decarboxylase activity than that found in the presence of phenyl metabolites. The degree of inhibition was progressive with increasing concentrations of inhibitors (1.25–5.00 mM). Simultaneous supplementation of different metabolites in conditions similar to those in experimental phenylketonuria (0.25 mM each) produced a clear inhibition of liver decarboxylase and 3-hydroxy-3-methylglutaryl-CoA reductase. To our knowledge, this is the first report on the in vitro inhibition of both liver regulatory enzymes of cholesterogenesis in phenylketonuria-like conditions. Our results show a lower inhibition of decarboxylase than that of reductase but suggest an important regulatory role of decarboxylase in cholesterol synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230371
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