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  • Articles  (41)
  • Springer  (41)
  • 1995-1999  (13)
  • 1990-1994  (10)
  • 1940-1944  (2)
  • 1905-1909  (16)
  • Chemistry and Pharmacology  (41)
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  • Articles  (41)
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  • 1
    Electronic Resource
    Electronic Resource
    Komplexe Zusammenhänge zwischen Eigenschaften und Strukturparametern von Elektrodengläsern (1995)
    Springer
    Monatshefte für Chemie 126 (1995), S. 839-850 
    Details
    ISSN: 1434-4475
    Keywords: Electrode glasses ; Principal Component Analysis ; Cluster analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Cluster Analysis has been shown to be partially suitable for the classification of glasses. The expansion of the clusters on theSeger's diagram allows an investigation of the influence of the different glass components. Variation of the SiO2 content results in a smaller change of properties than variation of the Na2O/RO relationship. Principal Component Analysis is convenient for showing correlations between the composition of the examined glasses, the glass structure parameters, and the different electrode properties. Properties of electrodes are mostly influenced by the content of Na2O and by the kind of the divalent cations. In contrast thereto structure parameters become basically determined by the content of SiO2 and RO. The field strength of the divalent cations plays the decisive roll again.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811003
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of chemically modified silica by infrared and solid state nuclear magnetic resonance spectroscopy (1997)
    Springer
    Fresenius' journal of analytical chemistry 358 (1997), S. 240-241 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Silica modified with benzene was investigated by infrared and solid state 13C cross-polarization magic angle spinning nuclear magnetic resonance spectroscopy (13C CP MAS NMR). Whereas infrared spectroscopy did not allow to distinguish between phenyl and polyphenyl groups, this was possible by solid state nuclear magnetic resonance spectroscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050394
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  • 3
    Electronic Resource
    Electronic Resource
    29Si NMR investigations on oligosilane dendrimers (1997)
    Springer
    Fresenius' journal of analytical chemistry 357 (1997), S. 503-504 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Starting with the high functionalized trisilane SiClMe(SiCl2Me)2 and tetrasilane SiMe(SiCl2Me)3 several octa- and decasilane dendrimers containing directly neighboured branchings were prepared. In these compounds the 29Si NMR chemical shifts of the different silyl groups are shifted towards lower field compared with those of analogous groups in tetra- or hexasilanes. This observation is a helpful tool for the characterization of further dendritic oligomers by 29Si NMR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050201
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  • 4
    Electronic Resource
    Electronic Resource
    15N CP/MAS NMR as an instrument in structure investigations of organosilicon polymers (1999)
    Springer
    Fresenius' journal of analytical chemistry 363 (1999), S. 185-188 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract 15N solid state NMR without enrichment is rarely used because of the low sensitivity and low natural abundance of this nucleus. As demonstrated on different nitrogen-containing polysilanes and polysilazanes, it can be shown that with the CP/MAS technique spectra can be obtained in good quality and within acceptable measuring time. Three main different nitrogen sites – NSi3, NSi2H and NSiH2– can be observed as well as changes in the intensities of these sites with reaction and tempering conditions. Thus the spectra give valuable additional information for a better understanding of the structures and their changes within the investigated systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160051168
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  • 5
    Electronic Resource
    Electronic Resource
    Determination of Moisture in Intact Gelatin Capsules by Near-Infrared Spectrophotometry (1995)
    Springer
    Pharmaceutical research 12 (1995), S. 161-163 
    Details
    ISSN: 1573-904X
    Keywords: gelatin capsules ; moisture content ; near-infrared spectrophotometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016219611132
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  • 6
    Electronic Resource
    Electronic Resource
    The third leg: Molecular dynamics simulations of lipid binding proteins (1999)
    Springer
    Molecular and cellular biochemistry 192 (1999), S. 143-156 
    Details
    ISSN: 1573-4919
    Keywords: molecular dynamics ; LBP ; FABP ; structure-function ; protein-lipid interactions ; rational drug design
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Molecular dynamics computer simulations can provide a third leg which balances the contributions of both structural biology and binding studies performed on the lipid binding protein family. In this context, these calculations help to establish a dialogue between all three communities, by relating experimental observables with details of structure. Working towards this connection is important, since experience has shown the difficulty of inferring thermodynamic properties from a single static conformation. The challenge is exemplified by ongoing attempts to interpret the impact of mutagenesis on structure and function (i.e. binding). A detailed atomic-level understanding of this system could be achieved with the support of all three legs, paving the way towards rational design of proteins with novel specificities. This paper provides an outline of the connections possible between experiment and theory concerning lipid binding proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006818203334
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  • 7
    Electronic Resource
    Electronic Resource
    Post-receptor defect accounts for phosphorylase hypersensitivity in cultured diabetic cardiomyocytes (1992)
    Springer
    Molecular and cellular biochemistry 117 (1992), S. 63-70 
    Details
    ISSN: 1573-4919
    Keywords: glycogen phosphorylase ; alloxan-diabetes ; cardiomyocytes ; G-protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The basis for the hypersensitive response of glycogen phosphorylase to epinephrine stimulation was investigated in adult rat cardiomyocytes isolated from normal and alloxan-diabetic animals. To assess potential G-protein involvement in the response, normal and diabetic derived myocytes were incubated with either cholera or pertussis toxin prior to hormonal stimulation. Pretreatment of cardiomyocytes with cholera toxin resulted in a potentiated response to epinephrine stimulation whereas pertussis toxin did not affect the activation of this signaling pathway. To determine if the enhanced response of phosphorylase activation resulted from an alteration in adenylate cyclase activation, the cells were challenged with forskolin. After 3 hr in primary culture, diabetic cardiomyocytes exhibited a hypersensitive response to forskolin stimulation relative to normal cells. However, after 24 hr in culture, both normal and diabetic myocytes responded identically to forskolin challenge. The present data suggest that a cholera toxin sensitive G-protein mediates the hypersensitive response of glycogen phosphorylase to catecholamine stimulation in diabetic cardiomyocytes and this response which is present in alloxan-diabetic cells and is induced in vitro in normal cardiomyocytes is primarily due to a defect at a post-receptor site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230411
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  • 8
    Electronic Resource
    Electronic Resource
    Transformation of adult ventricular myocytes with the temperature sensitive A58 (tsA58) mutant of the SV40 large T antigen (1994)
    Springer
    Molecular and cellular biochemistry 136 (1994), S. 29-34 
    Details
    ISSN: 1573-4919
    Keywords: cardiomyocytes ; SV40 large T antigen ; retroviral infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Freshly isolated ventricular myocytes have been used extensively as an adult cardiac model system. Due to their inability to undergo cytokinesisin vitro and their dedifferentiated properties in long-term culture, they can not be used for extended studies. Recent reports tell of the establishment of fetal and neonatal cardiac cell lines and the development of adult cardiomyocytes from transgenic animals. A recent report by Kirshenbaum [1], is the first to demonstrate insertion of genes in to adult ventricular myocytes using viral infection. This paper discusses the infection of primary adult differentiated cardiomyocytes with the SV40 large T antigen and subsequent proliferation under temperature sensitive control. Upon further characterization, the cells could be used as a model to study muscle differentiation and repair as well as adult cardiac cell physiology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00931601
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  • 9
    Electronic Resource
    Electronic Resource
    Identification of the molecular basis for phosphorylase hypersensitivity in cultured diabetic cardiomyocytes (1995)
    Springer
    Molecular and cellular biochemistry 145 (1995), S. 131-139 
    Details
    ISSN: 1573-4919
    Keywords: glycogen phosphorylase ; alloxan-diabetes ; cardiomyocytes ; cGMP ; phosphodiesterase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The focus of this study was to identify the molecular basis for the hypersensitive response of glycogen phosphorylase activation to epinephrine stimulation in alloxan diabetic-derived cardiomyocytes. Cyclic AMP levels were found not to be significantly different between normal and diabetic-derived cells while cGMP concentrations were found consistently to be significantly lower in diabetic-derived cells than in normal cells. Treatment with cyclic GMP analogues did not affect phosphorylase activation by epinephrine in normal cardiomyocytes whereas, IBMX, a nonselective phosphodiesterase inhibitor, had a significant effect on basal and agonist-stimulated phosphorylase activity in both normal and diabetic-derived cardiomyocytes. Differences in the time course for the rate of decay of phosphorylasea from agonist-stimulated to basal levels were observed between normal and diabetic cells. After 3 h in primary culture, phosphorylasea activity returned to basal levels more quickly in normal than in diabetic-derived cells while after 24 h in culture, the time for phosphorylasea decay was not significantly different between normal and diabetic myocytes and was longer than the 3 h response. After 3 h in primary culture, no significant difference in phosphorylase kinase activity was observed between normal and diabetic-derived cells exposed to epinephrine whereas, after 24 h in culture, phosphorylase kinase activity was significantly decreased in diabetic cells under basal and agonist-stimulated conditions. These data collectively suggest that the hypersensitive response of glycogen phosphorylase to epinephrine stimulation in diabetic-derived cardiomyocytes is not due to a defect present at the level of phosphorylase kinase but may, in part, result from an alteration in cardiac phosphodiesterase activity resulting from diminished intracellular cyclic GMP concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00935485
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  • 10
    Electronic Resource
    Electronic Resource
    Purification and the immunological characterization of rat protein phosphatase 2A: enzyme levels in diabetic liver and heart (1991)
    Springer
    Molecular and cellular biochemistry 101 (1991), S. 167-174 
    Details
    ISSN: 1573-4919
    Keywords: rat protein phosphatase 2A ; liver ; heart ; diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Protein phosphatase 2A1 was purified from rat skeletal muscle and used to produce antisera to the three subunits of the holoenzyme. Affinity purified antibodies specific for the subunits of the phosphatase enzyme were found to recognize the type 2A1 and 2A2 phosphatase from rat skeletal muscle, heart, liver, brain and erythrocytes and were used to investigate the effects of diabetes on the levels of this enzyme in liver and heart. Phosphorylase phosphatase assays coupled with immunoblot analysis of fractionated rat liver and heart cytosol from normal and diabetic animals show no apparent differences in the quantity or activity of these enzymes following the induction of alloxan diabetes. When considering these results and the normal physiological concentrations of known effectors of these enzymes, it is likely that protein phosphatase 2A1 and 2A2 are not responsible for the dephosphorylation of phosphorylase a under physiological conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229533
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