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  • Springer  (1,410)
  • 1995-1999  (525)
  • 1990-1994  (486)
  • 1985-1989  (387)
  • 1955-1959  (12)
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  • 1
    Publication Date: 1993-09-01
    Print ISSN: 0164-0313
    Electronic ISSN: 1572-9591
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Springer
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  • 2
    ISSN: 1433-3058
    Keywords: Neural networks ; Length-of-stay ; Psychiatry ; Resource utilization ; Back propagation ; Field study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract Demands for health care reform will increase service utilization, much of which will fall on a system of expanded primary care providers, many of whom will not be specialists in psychiatry. These providers will need tools to augment their decision-making process. In this paper, we explore the use of Artificial Neural Networks (ANNs) in three different field sites to predict inpatient psychiatric Length-Of-Stay (LOS). This study describes the development and implementation of a runtime system in three different psychiatric facilities. Data was collected at these respective sites using the runtime system, and then this data was used to retrain the networks to determine if site-specific data would improve accuracy of prediction of LOS. The results indicate that ANNs trained with state hospital data could accurately predict LOS in two different community hospital psychiatric units. When the respective ANNs were retrained with approximately 10% new data from these specific hospitals, rates of improvement ranged from 3% to 15%. Our findings demonstrate that an ANN can adapt to different treatment settings and, when retrained, significantly improve prediction of LOS. Prediction rates by the ANN after retraining are comparable to results of a clinical team.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of mathematical biology 53 (1991), S. 751-768 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Two series expressions were obtained that give the first and second order rates of change in population fitness during competitive replication at elevated mutation rates. At their zeroerror limit, the respective power series reduces to the second (Fisher’s theorem) and third moments of the fitness distribution. The first series maximized the variation in mean polymer fitness, for a given amount of population covariance. From experimental results reported by Spiegelman’s group on evolutionin vitro among Qβ RNA variants, it was demonstrated: (i) terms in the (second) series fall-off at a rate broadly equal to the replicase error (ε≅10−4); (ii) the rate of change in mean RNA fitness (polymer formation rate constant) corresponds to the variance in fitness; and (iii) agreement exists between second order rate changes in fitness and the third moment (skewness) regression line, extending over 20 successive replication reactions. The impact of these findings on the standard model of evolution has been discussed.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of mathematical biology 58 (1996), S. 99-101 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract As in Darwinian evolution, population fitness increases among replicating molecules whose propagation rate coefficients form a normal (symmetric) distribution, even when replication kinetics are fractional order.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of mathematical biology 58 (1996), S. 65-97 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract A theory has been proposed that encompasses pre-replication changes in RNA synthesis and non-gradual variant formation, in addition to competitive replication. Using a fundamental theorem of natural selection and maximum principle scaled to nucleotide condensation, evolutionin vitro was demonstrated to maximally damp both kinetic and thermodynamic forces driving this reaction, from its pre-replication stage. This led to the finding that evolution follows a path of least action. These principles form the framework for a general theory of evolution, whose scope extends beyond evolution modeled by synthesis of non-interacting RNA molecules. It applies, in particular, to standard processes, such as competitive crystallization. In calculations simulatingde novo formation of self-replicating RNA molecules in the Qβ replicase system, spontaneous changes in strand secondary structure promoted the transition from random copolymerization to template-directed polymerization. This finding indicates selection preceded genome self-propagation. Non-gradual species formation was attributed to the presence of heterogeneous thermodynamic forces. Growth unconstrained by competition follows mutation to a variant able to utilize a free energy source alien to its progenitors. Evolution in a heterogeneous system can, therefore, exhibit discontinuous rates of species formation and spawn new species populations. Natural selection among competing self-propagators thus gives way to a principle of wider scope stating that evolution optimally damps the physicochemical forces causing change within an evolving system.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 22 (1999), S. 80-87 
    ISSN: 1476-5535
    Keywords: Keywords: airborne bacteria; phospholipid fatty acids; human health
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Exposure to airborne biocontaminants may result in a multitude of health effects and is related to a pronounced increase in adult-onset asthma. Established culture-based procedures for quantifying microbial biomass from airborne environments have severe limitations. Assay of the phospholipid fatty acid (PLFA) components of airborne microorganisms provides a quantitative method to define biomass, community composition and nutritional/physiological activity of the microbial community. By collecting airborne particulate matter from a high volume via filtration, we collected sufficient biomass for quantitative PLFA analysis. Comparing high (filtration) and low (impaction) volume air sampling techniques at 26 locations within the Eastern United States, we determined that PLFA analysis provided a viable alternative to the established but flawed culture-based techniques for measuring airborne microbial biomass and community composition. Compared to the PLFA analysis, the culture techniques underestimated the actual viable airborne biomass present by between one to three orders of magnitude. A case study of a manufacturing plant at which there had been complaints regarding the indoor air quality is presented. Phospholipid fatty acid characterization of the biomass enabled contamination point source determination. In comparison with samples taken outdoors, increases in the relative proportion of trans PLFA, reflecting shifts in the physiological status of viable airborne Gram-negative bacteria, were detected in the indoor air samples at a majority of sampling sites.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 22 (1999), S. 78-79 
    ISSN: 1476-5535
    Keywords: Keywords: Actinomadura; pravastatin; compactin; nutrition; vitamins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Actinomadura sp strain 2966, which converts compactin to pravastatin, requires vitamins to support its growth. Addition of folic acid, thiamine and cyanocobalamine allowed growth in chemically-defined medium. Cells grown in a chemically-defined medium were as capable of converting compactin to pravastatin as cells grown in a complex medium.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1476-5535
    Keywords: Aflatoxin miniassay ; Fluorescence analysis ; Aspergillus flavus ; Aspergillus parasiticus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary A convenient miniassay for aflatoxin has been developed for cultures ofAspergillus flavus andA. parasiticus grown for 3–10 days in 10 ml of a coconut extract medium. The sensitivity of the assay, as measured by photofluorometry (365 nm maximum excitation; 445 nm maximum emission), is of the order of 0.01 μM (3.12 ng/ml) for aflatoxin B1 dissolved in aqueous iodine (0.26 mM). High performance liquid chromatography, monitored by fluorometric analysis of both an aflatoxin B1 standard and selected culture filtrates, confirmed the sensitivity of the assay and indicated specificity for iodine-enhanced fluorescence of aflatoxin in the coconut extract medium. Thin layer chromatography further confirmed the aflatoxin titers and the specificity for enhancement of aflatoxins B1 and G1 in culture filtrates.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Research in engineering design 4 (1992), S. 147-158 
    ISSN: 1435-6066
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract One of the fundamental axioms of concurrent engineering is that undertaking functional design without foreseeing the manufacturing process leads to production delays and increased costs. This widely accepted concurrent engineering principle is given a formal basis by development of a mathematical model for the conversion of a feature-based design representation to a manufacturing representation. Within the domain of thin-walled components, it is shown that the conversion to tooling cost representations can result in a discontinuous function when the sets of design and manufacturing representations have been formulated as topological spaces. This discontinuity formally reflects the folklore that a small design change can significantly increase product cost. The mathematical sophistication required within this model is suggestive of why manufacturability evaluations can be quite difficult.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Stochastic environmental research and risk assessment 3 (1989), S. 97-110 
    ISSN: 1436-3259
    Keywords: ARMA processes ; fractionally differencedARMA processes ; long memory ; spectral density ; maximum likelihood estimates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract A class of regression type estimators of the parameterd in a fractionally differencedARMA (p, q) process is introduced. This class is an extension of the estimator considered by Geweke and Porter-Hudak. In a simulation study, we compared three estimators from this class together with two approximate maximum likelihood estimators which are based on two separate approximations to the likelihood. One approximation ignores the determinant term in the likelihood and the other includes a compensating factor for the determinant. When the determinant term is included, the estimate tends to be much less biased and is in general superior to the other estimate. The approximate maximum likelihood estimator out performed, by a large margin, the regression type estimators for pureARIMA (0,d,0) processes. However, forARIMA (1,d,1) processes, a regression type estimator turned out to be the best for realizations of length 400 in 3 out of the 5 cases we tried.
    Type of Medium: Electronic Resource
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