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  • 1
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    Role of microRNAs in plant and animal development (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-07-19
    Description: Small RNAs, including microRNAs (miRNAs) and short interfering RNAs (siRNAs), are key components of an evolutionarily conserved system of RNA-based gene regulation in eukaryotes. They are involved in many molecular interactions, including defense against viruses and regulation of gene expression during development. miRNAs interfere with expression of messenger RNAs encoding factors that control developmental timing, stem cell maintenance, and other developmental and physiological processes in plants and animals. miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carrington, James C -- Ambros, Victor -- AI43288/AI/NIAID NIH HHS/ -- GM34028/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2003 Jul 18;301(5631):336-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA. carrington@orst.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12869753" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/genetics/*growth & development ; Drosophila/genetics/*growth & development ; *Gene Expression Regulation, Developmental ; *Gene Expression Regulation, Plant ; Gene Silencing ; MicroRNAs/*metabolism ; *Plant Development ; Plants/genetics/metabolism ; RNA, Plant
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    An extensive class of small RNAs in Caenorhabditis elegans (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-10-27
    Description: The lin-4 and let-7 antisense RNAs are temporal regulators that control the timing of developmental events in Caenorhabditis elegans by inhibiting translation of target mRNAs. let-7 RNA is conserved among bilaterian animals, suggesting that this class of small RNAs [microRNAs (miRNAs)] is evolutionarily ancient. Using bioinformatics and cDNA cloning, we found 15 new miRNA genes in C. elegans. Several of these genes express small transcripts that vary in abundance during C. elegans larval development, and three of them have apparent homologs in mammals and/or insects. Small noncoding RNAs of the miRNA class appear to be numerous and diverse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, R C -- Ambros, V -- R01 GM-34028/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2001 Oct 26;294(5543):862-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11679672" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Blotting, Northern ; Caenorhabditis elegans/*genetics/growth & development ; Cloning, Molecular ; Computational Biology ; Conserved Sequence ; DNA, Intergenic ; Gene Expression Regulation ; Gene Expression Regulation, Developmental ; Gene Library ; Genes, Helminth ; Humans ; Nucleic Acid Conformation ; Organ Specificity ; RNA Precursors/genetics/metabolism ; RNA, Antisense/chemistry/genetics/metabolism ; RNA, Helminth/chemistry/*genetics/metabolism ; RNA, Untranslated/chemistry/*genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Development. Dicing up RNAs (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-08-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ambros, V -- New York, N.Y. -- Science. 2001 Aug 3;293(5531):811-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA. vambros@dartmouth.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11486075" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/embryology/genetics ; Endoribonucleases/*metabolism ; Evolution, Molecular ; *Gene Expression Regulation, Developmental ; *Gene Silencing ; RNA/genetics/*metabolism ; RNA Precursors/metabolism ; RNA Processing, Post-Transcriptional ; RNA, Antisense/genetics/metabolism ; RNA, Double-Stranded/*genetics/*metabolism ; RNA, Helminth/genetics/metabolism ; Ribonuclease III
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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