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    Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-11
    Description: Previous work has identified two families of proteins that transport classical neurotransmitters into synaptic vesicles, but the protein responsible for vesicular transport of the principal excitatory transmitter glutamate has remained unknown. We demonstrate that a protein that is unrelated to any known neurotransmitter transporters and that was previously suggested to mediate the Na(+)-dependent uptake of inorganic phosphate across the plasma membrane transports glutamate into synaptic vesicles. In addition, we show that this vesicular glutamate transporter, VGLUT1, exhibits a conductance for chloride that is blocked by glutamate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bellocchio, E E -- Reimer, R J -- Fremeau, R T Jr -- Edwards, R H -- New York, N.Y. -- Science. 2000 Aug 11;289(5481):957-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, University of California at San Francisco School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143-0435, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10938000" target="_blank"〉PubMed〈/a〉
    Keywords: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid/pharmacology ; Adenosine Triphosphate/metabolism ; Animals ; Biological Transport, Active/drug effects ; Carrier Proteins/genetics/*metabolism ; Cell Membrane/metabolism ; Chlorides/metabolism ; Glutamic Acid/*metabolism ; Hydrogen-Ion Concentration ; PC12 Cells ; Phosphates/metabolism ; Potassium Chloride/metabolism ; Rats ; Sodium-Phosphate Cotransporter Proteins ; *Symporters ; Synaptic Vesicles/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-01
    Description: Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset of excitatory neurons in the adult. However, the same cell populations exhibited VGLUT1-independent transmission early in life. Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity. The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fremeau, Robert T Jr -- Kam, Kaiwen -- Qureshi, Tayyaba -- Johnson, Juliette -- Copenhagen, David R -- Storm-Mathisen, Jon -- Chaudhry, Farrukh A -- Nicoll, Roger A -- Edwards, Robert H -- R01 EY001869/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2004 Jun 18;304(5678):1815-9. Epub 2004 Apr 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15118123" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Brain/cytology/*metabolism ; Carrier Proteins/genetics/*metabolism ; Cell Membrane/physiology ; Cells, Cultured ; Cerebellum/metabolism/ultrastructure ; Excitatory Postsynaptic Potentials ; Glutamic Acid/metabolism ; Hippocampus/cytology/metabolism/ultrastructure ; In Situ Hybridization ; *Membrane Transport Proteins ; Mice ; Mice, Knockout ; Nerve Tissue Proteins/metabolism ; Neurons/*metabolism/physiology ; Patch-Clamp Techniques ; Purkinje Cells/physiology ; Pyramidal Cells/metabolism ; Synapses/*metabolism/ultrastructure ; *Synaptic Transmission ; Synaptic Vesicles/*metabolism/physiology ; Vesicular Glutamate Transport Protein 1 ; Vesicular Glutamate Transport Protein 2 ; *Vesicular Transport Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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