Publication Date:
2001-02-24
Description:
Exactly how signaling proteins know where they need to be in the cell is one of the intriguing mysteries of signal transduction biology. In a Perspective, Pouyssegur reviews new results that identify b-arrestin 2 as a scaffolding protein that holds together the different components of a MAPK signaling pathway that activates the transcription factor kinase, JNK3.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pouyssegur, J -- New York, N.Y. -- Science. 2000 Nov 24;290(5496):1515-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Signaling, Developmental Biology and Cancer Research, CNRS-UMR 6543, Nice 06189, France. pouysseg@unice.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11185509" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Arrestins/*metabolism
;
Cell Nucleus/metabolism
;
Cells, Cultured
;
Cytosol/metabolism
;
Endosomes/metabolism
;
Enzyme Activation
;
JNK Mitogen-Activated Protein Kinases
;
MAP Kinase Kinase 7
;
MAP Kinase Kinase Kinase 5
;
MAP Kinase Kinase Kinases/metabolism
;
*MAP Kinase Signaling System
;
Mitogen-Activated Protein Kinase 1/metabolism
;
Mitogen-Activated Protein Kinase 10
;
Mitogen-Activated Protein Kinase Kinases/metabolism
;
Mitogen-Activated Protein Kinases/*metabolism
;
Models, Biological
;
Protein-Tyrosine Kinases/*metabolism
;
Proto-Oncogene Proteins c-jun/metabolism
;
Receptor, Angiotensin, Type 1
;
Receptor, PAR-2
;
Receptors, Angiotensin/metabolism
;
Receptors, Thrombin/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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