Publikationsdatum:
2004-05-08
Beschreibung:
Self-regulating systems often use robust oscillatory circuits. One such system controls the chemotactic signaling mechanism of Dictyostelium, where pulses of adenosine 3',5'-monophosphate (cAMP) are generated with a periodicity of 7 minutes. We have observed spontaneous oscillations in activation of the mitogen-activated protein (MAP) kinase ERK2 that occur in phase with peaks of cAMP, and we show that ERK2 modulates cAMP levels through the phosphodiesterase RegA. Computer modeling and simulations of the underlying circuit faithfully account for the ability of the cells to spontaneously generate periodic pulses during specific stages of development. Similar oscillatory processes may occur in cells of many different species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maeda, Mineko -- Lu, Sijie -- Shaulsky, Gad -- Miyazaki, Yuji -- Kuwayama, Hidekazu -- Tanaka, Yoshimasa -- Kuspa, Adam -- Loomis, William F -- GM52359/GM/NIGMS NIH HHS/ -- GM62350/GM/NIGMS NIH HHS/ -- R01 GM052359/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 May 7;304(5672):875-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Graduate School of Science, Osaka University, Machikaneyama-cho 1-16, Toyonaka, Osaka 560-0043, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15131307" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
3',5'-Cyclic-AMP Phosphodiesterases
;
Adenylyl Cyclases/metabolism
;
Animals
;
Computer Simulation
;
Cyclic AMP/*metabolism
;
Cyclic AMP-Dependent Protein Kinases/genetics/*metabolism
;
Dictyostelium/enzymology/genetics/growth & development/*metabolism
;
Enzyme Activation
;
Mitogen-Activated Protein Kinase 1/genetics/*metabolism
;
Models, Biological
;
Mutagenesis, Site-Directed
;
Mutation
;
Phosphorylation
;
Protozoan Proteins/genetics/metabolism
;
Receptors, Cyclic AMP/metabolism
;
*Signal Transduction
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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