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  • 1
    Electronic Resource
    Electronic Resource
    Controllability of a class of hybrid dynamic systems (III)—Multiple time-delay case (2003)
    Springer
    Applied mathematics and mechanics 24 (2003), S. 1063-1074 
    Details
    ISSN: 1573-2754
    Keywords: hybrid dynamic system ; switched linear system ; time-delay ; controllability ; controllable set ; switching sequence ; switching path ; TP13 ; TP273 ; O317 ; 93B05 ; 93B27 ; 93C99
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract The controllability for switched linear systems with time-delay in controls is first investigated. The whole work contains three parts. This is the third part. The definition and determination of controllability of switched linear systems with multiple time-delay in control functions is mainly investigated. The sufficient and necessary conditions for the one-periodic, multiple-periodic controllability of periodic-type systems and controllability of aperiodic systems are presented, respectively. Finally, the case of distinct delays is discussed, it is shown that the controllability is independent of the size of delays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02437638
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  • 2
    Electronic Resource
    Electronic Resource
    Controllability of a class of hybrid dynamic systems (II)—Single time-delay case (2003)
    Springer
    Applied mathematics and mechanics 24 (2003), S. 1051-1062 
    Details
    ISSN: 1573-2754
    Keywords: hybrid dynamic system ; switched linear system ; time-delay ; controllability ; controllable set ; switching sequence ; switching path ; TP13 ; TP273 ; O317 ; 93B05 ; 93B27 ; 93C99
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract The controllability for switched linear systems with time-delay in controls is first investigated. The whole work contains three parts. This is the second part. The definition and determination of controllability of switched linear systems with single time-delay in control functions is mainly investigated. The sufficient and necessary conditions for the oneperiodic, multiple-periodic controllability of periodic-type systems and controllability of periodic systems are presented, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02437637
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  • 3
    Electronic Resource
    Electronic Resource
    Controllability of a class of hybrid dynamic systems (I)—Basic properties and preliminary results (2003)
    Springer
    Applied mathematics and mechanics 24 (2003), S. 1041-1050 
    Details
    ISSN: 1573-2754
    Keywords: hybrid dynamic system ; switched linear system ; time-delay ; controllability ; generalized cyclic invariant subspace ; switching sequence ; switching path ; TP13 ; TP273 ; O317 ; 93B05 ; 93B27 ; 93C99
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract The controllability for switched linear system with time-delay in controls was first investigated. The whole work contains three parts. This is the first part, including problem formulation and some preliminaries. Firstly, the mathematical model of switched linear systems with time-delay in control functions was presented. Secondly, the concept of column space, cyclic invariant subspace and generalized cyclic invariant subspace were introduced. And some basic properties, such as separation lemma, were presented. Finally, a basic lemma was given to reveal the relation between the solution set of a centain integral equations and the generalized cyclic invariant subspace. This lemma will play an important role in the determination of controllability. All these definitions and lemmas are necessary research tools for controllability analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02437636
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  • 4
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    Parasitology. Malaria--from infants to genomics to vaccines (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Long, Carole A -- Hoffman, Stephen L -- New York, N.Y. -- Science. 2002 Jul 19;297(5580):345-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Malaria Vaccine Development Unit, National Institutes of Health, Rockville, MD 20852, USA. clong@niaid.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12130768" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Protozoan/immunology ; Antigens, Protozoan/immunology ; B-Lymphocytes/immunology ; Clinical Trials, Phase II as Topic ; Genes, Protozoan ; Genomics ; Host-Parasite Interactions ; Humans ; *Malaria/epidemiology/immunology/parasitology/prevention & control ; *Malaria Vaccines/immunology ; *Malaria, Falciparum/epidemiology/immunology/parasitology/prevention & control ; *Plasmodium/genetics/immunology/physiology ; *Plasmodium falciparum/immunology/physiology ; Proteome ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Group II introns designed to insert into therapeutically relevant DNA target sites in human cells (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-07-21
    Description: Mobile group II intron RNAs insert directly into DNA target sites and are then reverse-transcribed into genomic DNA by the associated intron-encoded protein. Target site recognition involves modifiable base-pairing interactions between the intron RNA and a 〉14-nucleotide region of the DNA target site, as well as fixed interactions between the protein and flanking regions. Here, we developed a highly efficient Escherichia coli genetic assay to determine detailed target site recognition rules for the Lactococcus lactis group II intron Ll.LtrB and to select introns that insert into desired target sites. Using human immunodeficiency virus-type 1 (HIV-1) proviral DNA and the human CCR5 gene as examples, we show that group II introns can be retargeted to insert efficiently into virtually any target DNA and that the retargeted introns retain activity in human cells. This work provides the practical basis for potential applications of targeted group II introns in genetic engineering, functional genomics, and gene therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guo, H -- Karberg, M -- Long, M -- Jones, J P 3rd -- Sullenger, B -- Lambowitz, A M -- AI40981/AI/NIAID NIH HHS/ -- GM37949/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Jul 21;289(5478):452-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry, and Section of Molecular Genetics and Microbiology, School of Biological Sciences, University of Texas, Austin, TX 78712, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10903206" target="_blank"〉PubMed〈/a〉
    Keywords: Base Pairing ; Base Sequence ; Cell Line ; DNA/*genetics ; DNA, Viral/genetics ; Escherichia coli/genetics ; *Gene Targeting ; Genes, pol ; Genetic Therapy ; HIV-1/genetics ; Humans ; *Introns ; Lactococcus lactis/genetics ; Molecular Sequence Data ; Proviruses/genetics ; RNA, Catalytic/*genetics ; Receptors, CCR5/genetics ; Recombination, Genetic ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Extensive gene traffic on the mammalian X chromosome (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-24
    Description: Mammalian sex chromosomes have undergone profound changes since evolving from ancestral autosomes. By examining retroposed genes in the human and mouse genomes, we demonstrate that, during evolution, the mammalian X chromosome has generated and recruited a disproportionately high number of functional retroposed genes, whereas the autosomes experienced lower gene turnover. Most autosomal copies originating from X-linked genes exhibited testis-biased expression. Such export is incompatible with mutational bias and is likely driven by natural selection to attain male germline function. However, the excess recruitment is consistent with a combination of both natural selection and mutational bias.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Emerson, J J -- Kaessmann, Henrik -- Betran, Esther -- Long, Manyuan -- GM-065429-01A1/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Jan 23;303(5657):537-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14739461" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Chromosomes, Human/genetics ; Chromosomes, Human, X/*genetics ; Chromosomes, Mammalian/genetics ; Computational Biology ; Dosage Compensation, Genetic ; Female ; Gene Expression Profiling ; Genes, Duplicate ; Genetic Linkage ; Genome ; Genome, Human ; Humans ; Introns ; Male ; Mice ; Monte Carlo Method ; Mutation ; Oligonucleotide Array Sequence Analysis ; Ovary/metabolism ; Pseudogenes/*genetics ; *Recombination, Genetic ; Retroelements/*genetics ; Selection, Genetic ; Sex Characteristics ; Testis/metabolism ; X Chromosome/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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