Publication Date:
2004-05-01
Description:
Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset of excitatory neurons in the adult. However, the same cell populations exhibited VGLUT1-independent transmission early in life. Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity. The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fremeau, Robert T Jr -- Kam, Kaiwen -- Qureshi, Tayyaba -- Johnson, Juliette -- Copenhagen, David R -- Storm-Mathisen, Jon -- Chaudhry, Farrukh A -- Nicoll, Roger A -- Edwards, Robert H -- R01 EY001869/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2004 Jun 18;304(5678):1815-9. Epub 2004 Apr 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15118123" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Newborn
;
Brain/cytology/*metabolism
;
Carrier Proteins/genetics/*metabolism
;
Cell Membrane/physiology
;
Cells, Cultured
;
Cerebellum/metabolism/ultrastructure
;
Excitatory Postsynaptic Potentials
;
Glutamic Acid/metabolism
;
Hippocampus/cytology/metabolism/ultrastructure
;
In Situ Hybridization
;
*Membrane Transport Proteins
;
Mice
;
Mice, Knockout
;
Nerve Tissue Proteins/metabolism
;
Neurons/*metabolism/physiology
;
Patch-Clamp Techniques
;
Purkinje Cells/physiology
;
Pyramidal Cells/metabolism
;
Synapses/*metabolism/ultrastructure
;
*Synaptic Transmission
;
Synaptic Vesicles/*metabolism/physiology
;
Vesicular Glutamate Transport Protein 1
;
Vesicular Glutamate Transport Protein 2
;
*Vesicular Transport Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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