Publication Date:
2001-09-15
Description:
We have assembled data from Caenorhabditis elegans DNA microarray experiments involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a three-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimension. The gene expression map can be used as a gene discovery tool to identify genes that are co-regulated with known sets of genes (such as heat shock, growth control genes, germ line genes, and so forth) or to uncover previously unknown genetic functions (such as genomic instability in males and sperm caused by specific transposons).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, S K -- Lund, J -- Kiraly, M -- Duke, K -- Jiang, M -- Stuart, J M -- Eizinger, A -- Wylie, B N -- Davidson, G S -- New York, N.Y. -- Science. 2001 Sep 14;293(5537):2087-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology and Genetics, Stanford University Medical School, Stanford, CA 94305, USA. kim@cmgm.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11557892" target="_blank"〉PubMed〈/a〉
Keywords:
Algorithms
;
Animals
;
Caenorhabditis elegans/*genetics/physiology
;
*Computational Biology
;
DNA Transposable Elements
;
DNA, Complementary
;
Databases, Factual
;
Female
;
*Gene Expression
;
*Gene Expression Profiling
;
Gene Expression Regulation
;
*Genes, Helminth
;
Genome
;
*Genomics
;
Helminth Proteins/biosynthesis/genetics
;
Intestines/physiology
;
Male
;
Muscles/physiology
;
Neurons/physiology
;
Nucleic Acid Hybridization
;
Oligonucleotide Array Sequence Analysis
;
Oocytes/physiology
;
RNA, Helminth/genetics
;
Software
;
Spermatozoa/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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