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  • Artikel  (2)
  • Springer  (2)
  • Elsevier
  • 2000-2004  (2)
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  • Artikel  (2)
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  • 1
    Digitale Medien
    Digitale Medien
    Levels of neurotransmitter amino acids in the cerebrospinal fluid of patients with acute ischemic insult (2000)
    Springer
    Neuroscience and behavioral physiology 30 (2000), S. 491-495 
    Details
    ISSN: 1573-899X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The dynamics of excitatory (glutamate, aspartate) and inhibitory (GABA, glycine) neurotransmitter amino acid contents in the cerebrospinal fluid were studied in 110 patients with hemispheric ischemic insult. These studies revealed significant increases in the levels of glutamate and aspartate in the first six hours of illness, and the level and duration of these changes correlated with the severity of the insult. Peak GABA and glycine levels were seen at the end of the first day after strokes, reflecting the delayed activation of the mechanisms of protective inhibition. The insufficiency of GABAergic mediation in strokes located in the hemispheres to a significant extent mirrored the severity of clinical features and the potential of restorative processes. Early significant biochemical criteria were identified for objective assessment of the severity of brain ischemia, and these had pronostic value for the course and outcome of strokes. The most unfavorable prognostic signs were the presence of low (or undetectable) GABA levels in the first days after insult and progressive increases in aspartate levels to the third day on the background of sharp reductions in glutamate levels (after initial elevation on the first day).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02462604
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of cyclic GABA derivative TZ-146 on the content of neurotransmitters in rat brain stem (2000)
    Springer
    Bulletin of experimental biology and medicine 129 (2000), S. 460-462 
    Details
    ISSN: 1573-8221
    Schlagwort(e): dopamine ; serotonin ; neurotransmitter aminoacids ; brain stem structures
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The effect of cyclic GABA derivative TZ-146 on the content of catecholamines, serotonin, their metabolites, and neurotransmitter amino acids in rat hypothalamus and brain stem was studied by high-performance liquid chromatography with electrochemical detection. Opposite changes in the content of homovanillic acid, aspartate, glutamate, and glycine in the examined structures were accompanied by inhibition of dopamine metabolism. Possible participation of cerebral glutamatergic system in the effect of TZ-146 is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02439802
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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