Publication Date:
2003-01-11
Description:
Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 converts naive T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+ regulatory T cells. Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hori, Shohei -- Nomura, Takashi -- Sakaguchi, Shimon -- New York, N.Y. -- Science. 2003 Feb 14;299(5609):1057-61. Epub 2003 Jan 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230-0045, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12522256" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD/analysis
;
Autoimmune Diseases/immunology/prevention & control
;
CD4-Positive T-Lymphocytes/immunology
;
Cytokines/biosynthesis
;
DNA-Binding Proteins/genetics/*metabolism
;
Forkhead Transcription Factors
;
Gastritis/immunology/prevention & control
;
*Immune Tolerance
;
Inflammatory Bowel Diseases/immunology/prevention & control
;
Lymphocyte Activation
;
Mice
;
Mice, Inbred BALB C
;
Mice, SCID
;
Mice, Transgenic
;
Mutation
;
Receptors, Antigen, T-Cell/immunology
;
Receptors, Interleukin-2/analysis
;
Recombinant Fusion Proteins/metabolism
;
Self Tolerance
;
T-Lymphocyte Subsets/cytology/immunology
;
T-Lymphocytes/immunology
;
T-Lymphocytes, Regulatory/*immunology/*metabolism
;
Thymus Gland/cytology/metabolism
;
Transduction, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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