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  • Wiley  (47)
  • Springer  (39)
  • American Physical Society  (16)
  • Nature Publishing Group  (6)
  • Public Library of Science (PLoS)
  • 2000-2004  (68)
  • 1975-1979  (38)
  • 1945-1949  (2)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Dominant and recessive deafness caused by mutations of a novel gene, TMC1 , required for cochlear hair-cell function (2002)
    [s.l.] : Nature Publishing Group
    Nature genetics 30 (2002), S. 277-284 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Positional cloning of hereditary deafness genes is a direct approach to identify molecules and mechanisms underlying auditory function. Here we report a locus for dominant deafness, DFNA36, which maps to human chromosome 9q13–21 in a region overlapping the DFNB7/B11 locus for recessive ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng842
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  • 2
    Electronic Resource
    Electronic Resource
    Beethoven, a mouse model for dominant, progressive hearing loss DFNA36 (2002)
    [s.l.] : Nature Publishing Group
    Nature genetics 30 (2002), S. 257-258 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Despite recent progress in identifying genes underlying deafness, there are still relatively few mouse models of specific forms of human deafness. Here we describe the phenotype of the Beethoven (Bth) mouse mutant and a missense mutation in Tmc1 (transmembrane cochlear-expressed gene 1). ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng848
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  • 3
    Electronic Resource
    Electronic Resource
    Advantage of rare HLA supertype in HIV disease progression (2003)
    [s.l.] : Nature Publishing Group
    Nature medicine 9 (2003), S. 928-935 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The highly polymorphic human leukocyte antigen (HLA) class I molecules help to determine the specificity and repertoire of the immune response. The great diversity of these antigen-binding molecules confers differential advantages in responding to pathogens, but presents a major obstacle to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm893
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  • 4
    Electronic Resource
    Electronic Resource
    Binding of α-foetoprotein to murine T cells (1975)
    [s.l.] : Nature Publishing Group
    Nature 256 (1975), S. 656-657 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To define the cell type(s) affected by AFP we studied the binding of AFP to the surface of various cells involved in the immune reaction using direct immunofluorescence on preparations of thymus derived lymphochtes (T cells), bone marrow derived lymphocytes (B cells) and macrophages. Mouse ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/256656a0
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  • 5
    Electronic Resource
    Electronic Resource
    Ageing The old worm turns more slowly (2002)
    [s.l.] : Nature Publishing Group
    Nature 419 (2002), S. 794-795 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] When the nematode worm Caenorhabditis elegans was first considered as a model for the study of ageing some 20 years ago, few foresaw how valuable it would prove to be. The past decade, in particular, has seen an explosion of work on the genetics of lifespan in this species. Building on pioneering ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/419794a
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  • 6
    Electronic Resource
    Electronic Resource
    Seed dispersal and movement patterns in two species of Ceratogymna hornbills in a West African tropical lowland forest (2000)
    Springer
    Oecologia 125 (2000), S. 249-257 
    Details
    ISSN: 1432-1939
    Keywords: Seed dispersal Seed shadow Hornbills Telemetry Tropical frugivory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. We studied two species of Ceratogymna hornbills, the black-casqued hornbill, C. atrata, and the white-thighed hornbill, C. cylindricus, in the tropical forests of Cameroon, to understand their movement patterns and evaluate their effectiveness as seed dispersers. To estimate hornbill contribution to a particular tree species' seed shadow we combined data from movements, determined by radio-tracking, with data from seed passage trials. For 13 individuals tracked over 12 months, home range varied between 925 and 4,472 ha, a much larger area than reported for other African avian frugivores. Seed passage times ranged from 51 to 765 min, with C. atrata showing longer passage times than C. cylindricus, and larger seeds having longer gut retention times than smaller seeds. Combining these data, we estimated that seed shadows were extensive for the eight tree species examined, with approximately 80% of seeds moved more than 500 m from the parent plant. Maximum estimated dispersal distances for larger seeds were 6,919 and 3,558 m for C. atrata and C. cylindricus, respectively. The extent of hornbill seed shadows suggests that their influence in determining forest structure will likely increase as other larger mammalian dispersers are exterminated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004420000445
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  • 7
    Electronic Resource
    Electronic Resource
    Observations of vertical atmospheric structure in a deep mountain valley (1977)
    Springer
    Meteorology and atmospheric physics 26 (1977), S. 39-50 
    Details
    ISSN: 1436-5065
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Description / Table of Contents: Zusammenfassung Im Dezember 1975 wurden durch eine Fesselballonsonde die vertikalen Temperatur- und Windprofile im Gore River Valley im westlichen Colorado ermittelt. Aus Beobachtungen an einem wolkenlosen Morgen bei einer anfangs starken Inversion im Tal zeigte sich, daß die Inversionsobergrenze stetig um 120 m Std−1. absank und nach ungefähr vier Stunden den Talgrund erreichte. Schwache Talabwinde wehten innerhalb der Inversionsschicht. während stärkere Talaufwinde oberhalb derselben herrschten. Eine Hypothese wird vorgeschlagen, um diese Beobachtungen zu erklären. Die Abkühlung am späten Nachmittag und am Abend, wobei die Bildung einer Inversion einsetzte, deren Schichtdicke in weniger als zwei Stunden 175 m betrug, ist Gegenstand einer gesonderten Untersuchung. Winde innerhalb der Inversionsschicht wurden nicht mehr von den Winden in der freien Atmosphäre beeinflußt und blieben im Laufe der Nacht sehr schwach. Bewölkung während der Erwärmungsperiode an einem Morgen hatte zur Folge, daß das Temperaturprofil sich Isothermie näherte, indem Erwärmung gleichmäßig im ganzen Luftraum des Tales sich fortsetzte.
    Notes: Summary A tethered balloon sounder was used to collect vertical temperature and wind structure data in the Gore River Valley of Western Colorado during December, 1975. Observations taken on a clear morning in which a deep inversion was initially present in the valley showed that the inversion top descended at a steady rate of ∼120 m hr−1. reaching the valley bottom after approximately 4 hours. Weak down-valley winds were present within the inversion layer while stronger up-valley winds prevailed above. A hypothesis is presented to account for these observations. A case study is presented for afternoon and evening cooling in which a ground-based inversion developed to a depth of 175 m in less than 2 hours. Winds within the inversion became decoupled from the synoptic-scale winds and remained very weak during the night. The effect of cloud cover during a morning heating cycle was to make the temperature soundings approach isothermal while sensible heating continued throughout the valley volume.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246534
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  • 8
    Electronic Resource
    Electronic Resource
    A Soft Computing Approach to Road Classification (2000)
    Springer
    Journal of intelligent and robotic systems 29 (2000), S. 349-387 
    Details
    ISSN: 1573-0409
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Current learning approaches to computer vision have mainly focussed on low-level image processing and object recognition, while tending to ignore high-level processing such as understanding. Here we propose an approach to object recognition that facilitates the transition from recognition to understanding. The proposed approach embraces the synergistic spirit of soft computing, exploiting the global search powers of genetic programming to determine fuzzy probabilistic models. It begins by segmenting the images into regions using standard image processing approaches, which are subsequently classified using a discovered fuzzy Cartesian granule feature classifier. Understanding is made possible through the transparent and succinct nature of the discovered models. The recognition of roads in images is taken as an illustrative problem in the vision domain. The discovered fuzzy models while providing high levels of accuracy (97%), also provide understanding of the problem domain through the transparency of the learnt models. The learning step in the proposed approach is compared with other techniques such as decision trees, naïve Bayes and neural networks using a variety of performance criteria such as accuracy, understandability and efficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008158907779
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  • 9
    Electronic Resource
    Electronic Resource
    New ways of determining structural groups in brown coals and their bioconversion products by FT IR spectroscopy (2000)
    Springer
    Applied microbiology and biotechnology 54 (2000), S. 681-685 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract New methods of determining the structural groups —COOH and —CH2— have been developed. The investigation of carboxyl groups is possible both after derivatization with p-fluorophenacylbromide and by quantitative interpretation of the Fourier transform infrared (FT IR) spectra. There exists a linear relationship between the results of these two methods that is generally valid for the analysis of all brown coal components. The maximum extinction coefficient of the symmetric stretching vibration band of the CH2 groups has been determined using model substances. This allows quantification of this structural group directly from the FT IR spectrum. The results agree with the contents of methylene groups as determined by 13C-cross polarization–magic angle spinning–nuclear magnetic resonance (13C CPMAS NMR) spectroscopy. Using these methods, the COOH and CH2 groups contained in brown coals of the North Rhine region and in their bioconversion products have been quantified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530000419
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  • 10
    Electronic Resource
    Electronic Resource
    How to make a metalloprotein (2001)
    [s.l.] : Nature Publishing Group
    Nature structural biology 8 (2001), S. 733-734 
    Details
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] In the more than half century since the great Danish biochemist Kaj Linderstrøm-Lang first enunciated the concept of the structural hierarchy of proteins, the complex processes of protein folding and assembly have captured the imagination and focus of investigators from many diverse fields. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nsb0901-733
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