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  • Springer  (29)
  • Nature Publishing Group  (4)
  • 2000-2004  (16)
  • 1990-1994  (10)
  • 1975-1979  (7)
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  • 1
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Existing protocols for the neural differentiation of mouse embryonic stem (ES) cells require extended in vitro culture, yield variable differentiation results or are limited to the generation of selected neural subtypes. Here we provide a set of coculture conditions that allows rapid and efficient ...
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 435-439 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The purification of nucleic acids from microbial and mammalian cells is a crucial step in many biological and medical applications. We have developed microfluidic chips for automated nucleic acid purification from small numbers of bacterial or mammalian cells. All processes, such as cell isolation, ...
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature biotechnology 19 (2001), S. 1117-1118 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Embryonic stem (ES) cells are renewable pluripotent cells capable of generating any cell type of an organism. ES cell technology in mice has been one of the foundations of modern molecular biology, allowing targeted manipulations of the mouse genome. The recent isolation of human ES cells initiated ...
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  • 4
    ISSN: 1572-9028
    Keywords: hydrogenation of aromatic nitro compounds ; Raney nickel ; vanadium promoter ; modified catalysts ; aryl hydroxylamine ; chloronitrobenzene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The effect of vanadium promotion of Raney nickel on aryl hydroxylamine accumulation in the catalytic hydrogenation of electron deficient aromatic nitro compounds was investigated. High accumulation of 70–80% was observed with unmodified Raney nickel. Vanadium promoters were able to modulate the accumulation and depending on the modifier used, an increase (up to 86%) or a decrease (down to 11%) was found. Higher rates were obtained in the former (up to a factor 1.3), lower ones in the latter case (down to a factor 0.1) compared to the unmodified system. Supported or unsupported NH4VO3 was usually the most efficient modifier for obtaining low accumulation and reasonable rates, but the optimum concentration and modification procedure had to be determined for every substrate separately. In cases of low accumulation, the vanadium promoters worked as disproportionation catalysts. Dehalogenation was not significantly influenced by the presence of promoters: in all cases dehalogenation took only place after both the nitro arene and aryl hydroxylamine compound had been consumed completely.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 18 (2000), S. 233-240 
    ISSN: 1434-6036
    Keywords: PACS. 75.30.Vn Colossal magnetoresistance - 78.70.Dm X-ray absorption spectra - 75.25.+z Spin arrangements in magnetically ordered materials (including neutron and spin-polarized electron studies, synchrotron-source x-ray scattering, etc.)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: X-ray absorption spectroscopy (XAS) and soft-X-ray magnetic circular dichroism (SXMCD) at the Mn L2,3-, Cr L2,3- and O-K edges of Sm0.5Ca0.5Mn1-xCrxO3 ( ) bulk polycrystalline samples have been performed at T=20 K below the ferromagnetic Curie temperature. We show the existence of a magnetic sublattice on each of the probed cations. Considering an electronically phase-separated system, results are compared with magnetization and resistivity measurements and a tentative correlation with magnetoresistance properties on such doped compounds is discussed.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Computing 18 (1977), S. 281-293 
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Die vorliegende Arbeit analysiert die Erfahrungen, die bei der Durchführung formaler Korrektheitsbeweise an schon exsiterenden Programmen gemacht wurden. Mit Hilfe der Hoareschen Methode der Programmverfikation wurde der von an Emden angegebene Quicksort Algorithmus als richtig bewiesen. Dafür was es jedoch notwendig, eine Reihe von Veränderungen an dem Algorithmus vorzunehmen, um ihn an das Beweisverfahren und die existierenden Axiome anzupassen. Die gegenseitige Einflußnahme der Veränderungen und des Beweisverfahrens werden analysiert und Schlüse über die Verwendbarkeit des Hoareschen Verifikationsverfahrens für existierende Programme werden gezogen.
    Notes: Abstract Using the Quicksort Algortihm, given by van Emden, an analysis is made how Hoare's method of program verification can be applied to already existing programs. Changes to these programs become necessary to adopt them to the proving method and to the existing axioms. The interdependencies between these changes and the verification method are discussed and conclusions are draw about the applicability of Hoare's Methods for proving already existing programs.
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  • 7
    ISSN: 1434-4475
    Keywords: Keywords. Homogeneous catalysis; Enantioselective hydrogenation; Heterocyclic arenes; Rh diphosphine complexes.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary.  The first case of an enantioselective hydrogenation of monosubstituted pyridines and furans with homogeneous rhodium diphosphine catalysts with low but significant enantioselectivities and catalyst activities is reported. Best enantioselectivities (ees of 24–27%) were obtained for the hydrogenation of 2- and 3-pyridine carboxylic acid ethyl ester and 2-furan carboxylic acid with catalysts prepared in situ from [Rh(nbd)2]BF4 and the chiral ligands diop, binap, or ferrocenyl diphosphines of the josiphos type. Turnover numbers (ton) were in the order of 10–20, turnover frequencies (tof) usually 1–2 h−1. Diphosphines giving 6- or 7-ring chelates led to higher ees than 1,2-diphosphines; otherwise, no clear correlation between ligand properties and catalytic performance was found. In some experiments black precipitates were observed at the end of the reaction, indicating the decomposition of the homogeneous catalysts for certain ligand/metal/substrate combinations.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Policy sciences 8 (1977), S. 111-124 
    ISSN: 1573-0891
    Source: Springer Online Journal Archives 1860-2000
    Topics: Political Science , Economics
    Notes: Abstract It is argued that “successful” social science requires the development of a social ethic or sense of research responsibility. An examination of impediments to ethical reflection in sociology suggests that an individualistic orientation is ineffective in coping with the unintended consequences of social research. Such consequences can be particularly harmful in the sociology of science where policy research and governmental support for its production often entails an “indiscriminate advocacy of knowledge.” Such advocacy raises anew questions of the power of scientific knowledge, the definition of client-professional relationships, and the collection of data which may not only violate the intent of individuals and groups supplying information, but may undermine the credibility of sociology itself.
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  • 9
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A transgenic construct with 18 kilobases (kb) of genomic DNA from the Hoxb-1 gene can reconstruct both the early and late expression patterns, and its response to exogenous retinoic acid9. Deletion analysis in transgenic mice was used to identify the regulatory regions that mediate the early ...
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Communications in mathematical physics 139 (1991), S. 103-139 
    ISSN: 1432-0916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract We study the options for boundary conditions at the conical singularity for quantum mechanics on a two-dimensional cone with deficit angle ≦ 2π and for classical and quantum scalar fields propagating with a translationally invariant dynamics in the 1+3 dimensional spacetime around an idealized straight infinitely long, infinitesimally thin cosmic string. The key to our analysis is the observation that minus-the-Laplacian on a cone possesses a one-parameter family of selfadjoint extensions. These may be labeled by a parameterR with the dimensions of length—taking values in [0, ∞). ForR=0, the extension is positive. WhenR≠0 there is a bound state. Each of our problems has a range of possible dynamical evolutions corresponding to a range of allowedR-values. They correspond to either finite, forR=0, or logarithmically divergent, forR≠0, boundary conditions at zero radius. Non-zeroR-values are a satisfactory replacement for the (mathematically ill-defined) notion of δ-function potentials at the cone's apex. We discuss the relevance of the various idealized dynamics to quantum mechanics on a cone with a rounded-off centre and field theory around a “true” string of finite thickness. Provided one is interested in effects at sufficiently large length scales, the “true” dynamics will depend on the details of the interaction of the wave function with the cone's centre (/field with the string etc.) only through a single parameterR (its “scattering length”) and will be well-approximated by the dynamics for the corresponding idealized problem with the sameR-value. This turns out to be zero if the interaction with the centre is purely gravitational and minimally coupled, but non-zero values can be important to model nongravitational (or non-minimally coupled) interactions. Especially, we point out the relevance of non-zeroR-values to electromagnetic waves around superconducting strings. We also briefly speculate on the relevance of theR-parameter in the application of quantum mechanics on cones to 1+2 dimensional quantum gravity with massive scalars.
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