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  • 1
    Electronic Resource
    Electronic Resource
    A General Framework for Weighted Gene Co-Expression Network Analysis (2005)
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Statistical applications in genetics and molecular biology 4.2005, 1, art17 
    Details
    ISSN: 1544-6115
    Source: Berkeley Electronic Press Academic Journals
    Topics: Biology
    Notes: Gene co-expression networks are increasingly used to explore the system-level functionality of genes. The network construction is conceptually straightforward: nodes represent genes and nodes are connected if the corresponding genes are significantly co-expressed across appropriately chosen tissue samples. In reality, it is tricky to define the connections between the nodes in such networks. An important question is whether it is biologically meaningful to encode gene co-expression using binary information (connected=1, unconnected=0). We describe a general framework for `soft' thresholding that assigns a connection weight to each gene pair. This leads us to define the notion of a weighted gene co-expression network. For soft thresholding we propose several adjacency functions that convert the co-expression measure to a connection weight. For determining the parameters ofthe adjacency function, we propose a biologically motivatedcriterion (referred to as the scale-free topology criterion).We generalize the following important network concepts to the case of weighted networks. First, we introduce several node connectivity measures and provide empirical evidence that they can be important for predicting the biological significance of a gene. Second, we provide theoretical and empirical evidence that the `weighted' topological overlap measure (used to define gene modules) leads to more cohesive modules than its `unweighted' counterpart. Third, we generalize the clustering coefficient to weighted networks. Unlike the unweighted clustering coefficient,the weighted clustering coefficient is not inversely related to the connectivity. We provide a model that shows how an inverse relationship between clustering coefficient and connectivity arises from hard thresholding.We apply our methods to simulated data, a cancer microarray data set, and a yeast microarray data set.
    Type of Medium: Electronic Resource
    URL: http://www.bepress.com/sagmb/vol4/iss1/art17
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  • 2
    Electronic Resource
    Electronic Resource
    Preparation and CO〈sub〉2〈/sub〉 Gas Sensitive Properties of CuO-SrTiO〈sub〉3〈/sub〉-Based Semiconductor Thin Films (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 280-283 (Feb. 2007), p. 311-314 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: CuO-SrTiO3-based thin films were prepared by novel sol-gel technology on Al2O3 substrates using Cu(NO3)2, SrCl2 and TiCl4 as the starting materials, critic acid and ethylene glycol as chelating agents. CO2 sensing properties of the films were investigated. Structure characteristics of the sol and asgrown thin films were analyzed by FT-IR spectrum, X-ray diffraction and SEM. The results reveal thatthe films consisted of CuO phase and SrTiO3 phase have nanocrystalline microstructure at 750°C for 40 min. The modified CuO-SrTiO3 thin films exhibit good resistance-temperature and gas sensitivity properties in a wide range of temperature. The films exposed to 6% CO2 show that sensitivity are 32, andresponse and recover time are within 2 s at 250 °C operating temperature
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.280-283.311.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Evaluation of the Life Limit of Standard Hardness Block HRC64 at Ambient Temperature (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 118 (Dec. 2006), p. 21-26 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: The life limit of the standard hardness block of HRC64 made from JIS-SUJ2 steel wasevaluated. The HRC64 specimens were annealed at temperatures ranging from 55 to 200[removed info]C forabout 104 h in maximum. The micro-Vickeres hardness decreased with the annealing time at alltemperatures after some incubation periods. Transmission electron microscopy (TEM) showed thatthe microstructure of the specimen before annealing was composed of primary cementite particles,[removed info]carbide and martensite matrix. After annealing, fine cementite particles of about few tens ofnanometers in size were observed. The decrease in hardness during annealing was caused by theprecipitation of the cementite. The life limit keeping the standard hardness value at ambienttemperature was estimated to be about 3.5-4 years based on extrapolation of the annealing curves atvarious temperatures
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/22/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.118.21.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Raman Quantitate Stress in Nano-Thin Film of MEMS (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 121-123 (Mar. 2007), p. 943-946 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: The stress is an important parameter of nano-thin film of the micro-structure. It is essentialfor the successful design and operation of many micro-machined devices. In this paper, theexperiment idea that using Raman spectrometer to quantitate the stress in the nano-thin film ofMEMS was put forward and the formula of the stress of Si and GaAs crystal was derived. In theexperiment, the Si nano-thin film and AlAs/GaAs nano-thin film on GaAs substrate were grown byMBE (molecular beam epitaxy). The uniaxial pressure is exerted to nano-thin film by using thepressurization instrument designed by ourselves. Raman spectrums of the nano-thin film of MEMSare measured with the pressure exerted varying. Through the processing of the experiment data, theerror of measurement to stress in nano-thin film is maximally 0.9% to Si and 7.5% to GaAs. So,Raman spectrum can be used to accurately quantitate stress in nano-thin film of MEMS in order toassessment of the reliability of micromachined structure. And the method can be applied to quantitatethe stress in the experiment of testing the piezoresistor effect of double-quantum-well nano-thin film
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/23/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.121-123.943.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Structure and Wear Resistance at Elevated Temperature of Auto Brush-Plating n-Al〈sub〉2〈/sub〉O〈sub〉3〈/sub〉/Ni Composite Coatings (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 373-374 (Mar. 2008), p. 523-526 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Nanoparticle reinforced nickel matrix composite coating, n-Al2O3/Ni, was prepared bymanual brush-plating and auto brush-plating technologies. For the auto-coating, the surface wassmooth and made up of large quantity spheroid grain. The observed auto-coating’s structure wasdense. Compared with the auto-coating, the manual-coating’s surface was coarser, the grains thatform the surface were not spheroid but anomalistic and similar to cauliflower. The structure ofmanual-coating was sparser than the auto-coating’s. And the test found that the auto-coating’smicro-hardness improves 8% than the manual-coating’s. Results of the friction wear testing atelevated temperature showed that the wear resistance of auto-coating decreases while the temperaturegoes higher. It was concluded that during the process of auto-coating, with the help of computer, thespeed, pressure and flow brush liquid was stable. While during the manual process the parameterswere not controlled so that the quality of the coating was influenced. The other advantage of theauto-coating was set worker free from the front line, decrease harm to worker, provide comfortableworking condition, and keep the coating’s quality on a high level, can be adapted to large-scalepopularization and application
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/57/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.373-374.523.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Advances in Three-Dimensional Fracture Mechanics (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 312 (June 2006), p. 27-34 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The historical developments of the fracture mechanics from planar theory to threedimensional (3D) theory are reviewed. The two-dimensional (2D) theories of fracture mechanics have been developed perfectly in the past 80 years, and are suitable for some specific cases of engineering applications. However, in the complicated 3D world, the limitation of the 2D fracture theory has become evident with development of the structure toward complication and micromation.In the 1990’s, Guo has proposed the 3D fracture theory with a 3D constraint factor based on the deformation theory and energy theory. The proposed 3D theory can predict accurately the fracture problems for practical and complicated engineering structures with defects, by integrating the 3D theory of fatigue, which has been developed to unify fatigue and fracture. Our efforts to develop the 3D fracture mechanics and the unified theory of 3D fatigue and fracture are summarized, andperspectives for future efforts are outlined
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/51/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.312.27.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Biocompatibility of Near-IR Sensitive Au-Based Nanoparticles as the Potential Drug Delivery Carriers (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 334-335 (Mar. 2007), p. 1177-1180 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: We successfully synthesized near infrared (NIR) sensitive Au(shell)-Au2S(core)nanoparticles, where Au2S dielectric core was encapsulated by a thin gold shell. The cytotoxicity invitro and biodistribution in vivo of Au-Au2S nanoparticles was studied by using NIH3T3 cells andKM mice, respectively. The quantitative analysis of Au in each tissue of mice was done by using theInductively Coupled Plasma Mass Spectrometry (ICP-MS). Au-Au2S nanoparticles (〈 300 μg/ml)showed good biocompatibility. Au-Au2S nanoparticles were preferentially taken up by the liver andspleen, and ultimately eliminated mostly in the feces
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.334-335.1177.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of Surface Roughness on Matching Properties between Ceramic Framework and Coating-Glass for Dental Applications (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 1603-1605 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This study was conducted to evaluate the influence of surface roughness on anchoring strengthbetween ceramic and coating glass. Commercial Vita alpha glass-ceramic was selected as the coatingglass, while the zirconia/alumina (Z/A) composite as the substrate. Anchoring strength between substrateand coating-glass was tested, and microstructure of the junction was also observed. From the experimentswe can find the following results. There was significant difference in the mean strength of differentsurface roughness groups and HF acid-etching also had a favorable effect on matching properties. Thehighest amount of anchoring strength was occurred at the high scope of roughness after HF acid-etchingand surface roughness will also affect the microstructure of the junction. Therefore, we can draw theconclusions that with the limit of this research, roughness will influence matching properties betweenceramic substrate and coating-glass, while hydrofluoric acid etching was also suggested in the matchingprocedure. Testing matching properties between ceramic substrate and coating-glass should consider theinfluence of surface roughness
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1603.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Geometry Modeling for Indexing Cams Based on Screw Theory and Product of Exponential Formula (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 505-507 (Jan. 2006), p. 991-996 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper proposes a method of geometry modeling for indexing cam mechanism byusing screw theory and exponential product formula. Kinematic analysis based on screw theory is introduced firstly. Then, method to model surface of indexing cams is presented when screw theory and exponential product formula are applied. The paper gives examples to obtain the geometry models of roller gear cam, barrel indexing cam and parallel indexing cam. Our work suggests that thismethod can avoid the burdensome work on building coordinate systems, transformation matrixes and understanding on the mechanism. Moreover, this method can be used to innovate and design new types of indexing mechanism
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/12/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.505-507.991.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    The Transfection Efficacy of Chitosan-DNA Nanoparticles on MGC803, SMMC-7721, MG63 Cells (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 510-511 (Mar. 2006), p. 382-385 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Chitosan-DNA nanoparticles were synthesized from the complexation of chitosansolution and the plasmid pCD-GFP encoding green fluorescent protein through a coacervation process. The nanoparticles formed were of diameter inferior to 100 nm. The transfection efficacy of chitosan-DNA nanoparticles in MGC803 cells was higher than in SMMC-7721 cells, whereas the plasmid GFP was not expressed in MG63 cells
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/12/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.510-511.382.pdf
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