Publication Date:
2009-11-20
Description:
Abstract 4417 Nucleotides are new players in intercellular communication network. Abnormal signaling leads to cell dysfunction and diseases. P2X family receptors, consisting of seven members, are ATP-gated plasma membrane ion channels widely distributed in different organs, tissues, and cells with diverse biological functions. Their distribution patterns and significance in pediatric leukemias have not been established though the abnormal expression of P2×7 receptor was reported in leukemias. Here we investigated the expression of P2X family receptors in BMMC samples from 124 Chinese pediatric acute leukemia patients (85 boys and 39 girls; 66 newly diagnosed ALL, 37 newly diagnosed AML, 17 relapsed ALL, and 4 relapsed AML) with the median age of 8 (range, 1-16 years) as well as 20 childhood normal healthy controls. Relative quantitative real-time PCR results showed that P2×1, 4, 5, 7 receptors were simultaneously over expressed in newly diagnosed ALL patients (p=0.04, p
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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