ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 172-1063B; 172-1063D; AGE; Blake-Bahama Outer Ridge, North Atlantic Ocean; Calculated; DEPTH, sediment/rock; DRILL; Drilling/drill rig; DSDP/ODP/IODP sample designation; Event label; Inductively coupled plasma - mass spectrometry (ICP-MS); Joides Resolution; Leg172; Ocean Drilling Program; ODP; Protactinium-231; Protactinium-231, error, relative; Protactinium-231/Thorium-230 excess, decay-corrected; Protactinium-231/Thorium-230 excess, decay-corrected, error, relative; Sample code/label; South Atlantic Ocean; Thorium-230; Thorium-230, error, relative; Thorium-232; Thorium-232, error, relative; Uranium-234; Uranium-234, error, relative; Uranium-238; Uranium-238, error, relative  (1)
  • Alleles  (1)
  • 2005-2009  (2)
Collection
Keywords
Years
  • 2005-2009  (2)
Year
  • 1
    Publication Date: 2005-12-17
    Description: Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved ancestral allele of a human coding polymorphism predominates in African and East Asian populations. In contrast, the variant allele is nearly fixed in European populations, is associated with a substantial reduction in regional heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a key role for the SLC24A5 gene in human pigmentation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lamason, Rebecca L -- Mohideen, Manzoor-Ali P K -- Mest, Jason R -- Wong, Andrew C -- Norton, Heather L -- Aros, Michele C -- Jurynec, Michael J -- Mao, Xianyun -- Humphreville, Vanessa R -- Humbert, Jasper E -- Sinha, Soniya -- Moore, Jessica L -- Jagadeeswaran, Pudur -- Zhao, Wei -- Ning, Gang -- Makalowska, Izabela -- McKeigue, Paul M -- O'donnell, David -- Kittles, Rick -- Parra, Esteban J -- Mangini, Nancy J -- Grunwald, David J -- Shriver, Mark D -- Canfield, Victor A -- Cheng, Keith C -- CA73935/CA/NCI NIH HHS/ -- EY11308/EY/NEI NIH HHS/ -- HD37572/HD/NICHD NIH HHS/ -- HD40179/HD/NICHD NIH HHS/ -- HG002154/HG/NHGRI NIH HHS/ -- HL077910/HL/NHLBI NIH HHS/ -- RR017441/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1782-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357253" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans/genetics ; African Continental Ancestry Group/genetics ; Alanine/genetics ; Alleles ; Amino Acid Sequence ; Animals ; Antiporters/chemistry/*genetics/physiology ; Asian Continental Ancestry Group/genetics ; Biological Evolution ; Calcium/metabolism ; European Continental Ancestry Group/genetics ; Gene Frequency ; Genes ; Genetic Variation ; Haplotypes ; Heterozygote ; Humans ; Ion Transport ; Melanins/analysis ; Melanosomes/chemistry/ultrastructure ; Mice ; Molecular Sequence Data ; Multifactorial Inheritance ; Mutation ; Pigment Epithelium of Eye/chemistry/ultrastructure ; Polymorphism, Single Nucleotide ; Selection, Genetic ; Skin Pigmentation/*genetics ; Threonine/genetics ; Zebrafish/embryology/*genetics/metabolism ; Zebrafish Proteins/chemistry/*genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    facet.materialart.
    Unknown
    PANGAEA
    In:  Supplement to: Lippold, Jörg; Gruetzner, Jens; Winter, Diane M; Lahaye, Yann; Mangini, Augusto; Christl, Marcus (2009): Does sedimentary 231Pa/230Th from the Bermuda Rise monitor past Atlantic Meridional Overtuning Circulation? Geophysical Research Letters, 36, L12601, https://doi.org/10.1029/2009GL038068
    Publication Date: 2024-01-09
    Description: Ocean circulation may have undergone reductions and reinvigorations in the past closely tied to regional climate changes. Measurements of 231Pa/230Th ratios in a sediment core from the Bermuda Rise have been interpreted as evidence that the Atlantic Meridional Overturning Circulation (AMOC) was weakened or completely eliminated during a period of catastrophic iceberg discharges (Heinrich-Event 1, H1). Here we present new data from the Bermuda Rise that show further 231Pa/230Th peaks during Heinrich-2 (H2) and Heinrich-3 (H3). Additionally, a tight correlation between diatom abundances (biogenic silica) and 231Pa/230Th is discovered in this core. Our results redirect the interpretation of 231Pa/230Th from the Bermuda Rise as a proxy for ocean circulation towards a proxy that reacts highly sensitive to changes of particle composition and water mass properties.
    Keywords: 172-1063B; 172-1063D; AGE; Blake-Bahama Outer Ridge, North Atlantic Ocean; Calculated; DEPTH, sediment/rock; DRILL; Drilling/drill rig; DSDP/ODP/IODP sample designation; Event label; Inductively coupled plasma - mass spectrometry (ICP-MS); Joides Resolution; Leg172; Ocean Drilling Program; ODP; Protactinium-231; Protactinium-231, error, relative; Protactinium-231/Thorium-230 excess, decay-corrected; Protactinium-231/Thorium-230 excess, decay-corrected, error, relative; Sample code/label; South Atlantic Ocean; Thorium-230; Thorium-230, error, relative; Thorium-232; Thorium-232, error, relative; Uranium-234; Uranium-234, error, relative; Uranium-238; Uranium-238, error, relative
    Type: Dataset
    Format: text/tab-separated-values, 748 data points
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...