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  • 1
    Series available for loan
    Series available for loan
    Methods of measuring water levels in deep wells (1969)
    Washington, DC : United States Gov. Print. Off.
    Associated volumes
    Details Availability
    Call number: SR 90.0930(8, A1)
    In: Techniques of water-resources investigations of the United States Geological Survey
    Type of Medium: Series available for loan
    Pages: iv, 23 S.
    Edition: 2nd print.
    Series Statement: Techniques of water-resources investigations of the United States Geological Survey
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 2
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    Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-02-03
    Description: There is growing recognition that mammalian cells produce many thousands of large intergenic transcripts. However, the functional significance of these transcripts has been particularly controversial. Although there are some well-characterized examples, most (〉95%) show little evidence of evolutionary conservation and have been suggested to represent transcriptional noise. Here we report a new approach to identifying large non-coding RNAs using chromatin-state maps to discover discrete transcriptional units intervening known protein-coding loci. Our approach identified approximately 1,600 large multi-exonic RNAs across four mouse cell types. In sharp contrast to previous collections, these large intervening non-coding RNAs (lincRNAs) show strong purifying selection in their genomic loci, exonic sequences and promoter regions, with greater than 95% showing clear evolutionary conservation. We also developed a functional genomics approach that assigns putative functions to each lincRNA, demonstrating a diverse range of roles for lincRNAs in processes from embryonic stem cell pluripotency to cell proliferation. We obtained independent functional validation for the predictions for over 100 lincRNAs, using cell-based assays. In particular, we demonstrate that specific lincRNAs are transcriptionally regulated by key transcription factors in these processes such as p53, NFkappaB, Sox2, Oct4 (also known as Pou5f1) and Nanog. Together, these results define a unique collection of functional lincRNAs that are highly conserved and implicated in diverse biological processes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754849/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754849/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guttman, Mitchell -- Amit, Ido -- Garber, Manuel -- French, Courtney -- Lin, Michael F -- Feldser, David -- Huarte, Maite -- Zuk, Or -- Carey, Bryce W -- Cassady, John P -- Cabili, Moran N -- Jaenisch, Rudolf -- Mikkelsen, Tarjei S -- Jacks, Tyler -- Hacohen, Nir -- Bernstein, Bradley E -- Kellis, Manolis -- Regev, Aviv -- Rinn, John L -- Lander, Eric S -- DP1 OD003958/OD/NIH HHS/ -- R01 HG004037/HG/NHGRI NIH HHS/ -- R01 HG004037-02/HG/NHGRI NIH HHS/ -- U54 HG003067/HG/NHGRI NIH HHS/ -- U54 HG003067-05/HG/NHGRI NIH HHS/ -- England -- Nature. 2009 Mar 12;458(7235):223-7. doi: 10.1038/nature07672. Epub 2009 Feb 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19182780" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cells, Cultured ; Chromatin/*genetics ; *Conserved Sequence/genetics ; DNA, Intergenic ; Exons/genetics ; Mammals/*genetics ; Mice ; Promoter Regions, Genetic/genetics ; RNA/*genetics ; Reproducibility of Results ; Transcription Factors/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Genome sequence, comparative analysis, and population genetics of the domestic horse (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-11-07
    Description: We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785132/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785132/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, C M -- Giulotto, E -- Sigurdsson, S -- Zoli, M -- Gnerre, S -- Imsland, F -- Lear, T L -- Adelson, D L -- Bailey, E -- Bellone, R R -- Blocker, H -- Distl, O -- Edgar, R C -- Garber, M -- Leeb, T -- Mauceli, E -- MacLeod, J N -- Penedo, M C T -- Raison, J M -- Sharpe, T -- Vogel, J -- Andersson, L -- Antczak, D F -- Biagi, T -- Binns, M M -- Chowdhary, B P -- Coleman, S J -- Della Valle, G -- Fryc, S -- Guerin, G -- Hasegawa, T -- Hill, E W -- Jurka, J -- Kiialainen, A -- Lindgren, G -- Liu, J -- Magnani, E -- Mickelson, J R -- Murray, J -- Nergadze, S G -- Onofrio, R -- Pedroni, S -- Piras, M F -- Raudsepp, T -- Rocchi, M -- Roed, K H -- Ryder, O A -- Searle, S -- Skow, L -- Swinburne, J E -- Syvanen, A C -- Tozaki, T -- Valberg, S J -- Vaudin, M -- White, J R -- Zody, M C -- Broad Institute Genome Sequencing Platform -- Broad Institute Whole Genome Assembly Team -- Lander, E S -- Lindblad-Toh, K -- 098051/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2009 Nov 6;326(5954):865-7. doi: 10.1126/science.1178158.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA. c.wade@usyd.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19892987" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Domestic/genetics ; Centromere/genetics ; Chromosome Mapping ; Chromosomes, Mammalian/*genetics ; Computational Biology ; DNA Copy Number Variations ; Dogs ; Evolution, Molecular ; Female ; Genes ; *Genome ; Haplotypes ; Horses/*genetics ; Humans ; Molecular Sequence Data ; Phylogeny ; Repetitive Sequences, Nucleic Acid ; *Sequence Analysis, DNA ; Synteny
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-09-05
    Description: Models of mammalian regulatory networks controlling gene expression have been inferred from genomic data but have largely not been validated. We present an unbiased strategy to systematically perturb candidate regulators and monitor cellular transcriptional responses. We applied this approach to derive regulatory networks that control the transcriptional response of mouse primary dendritic cells to pathogens. Our approach revealed the regulatory functions of 125 transcription factors, chromatin modifiers, and RNA binding proteins, which enabled the construction of a network model consisting of 24 core regulators and 76 fine-tuners that help to explain how pathogen-sensing pathways achieve specificity. This study establishes a broadly applicable, comprehensive, and unbiased approach to reveal the wiring and functions of a regulatory network controlling a major transcriptional response in primary mammalian cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879337/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879337/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amit, Ido -- Garber, Manuel -- Chevrier, Nicolas -- Leite, Ana Paula -- Donner, Yoni -- Eisenhaure, Thomas -- Guttman, Mitchell -- Grenier, Jennifer K -- Li, Weibo -- Zuk, Or -- Schubert, Lisa A -- Birditt, Brian -- Shay, Tal -- Goren, Alon -- Zhang, Xiaolan -- Smith, Zachary -- Deering, Raquel -- McDonald, Rebecca C -- Cabili, Moran -- Bernstein, Bradley E -- Rinn, John L -- Meissner, Alex -- Root, David E -- Hacohen, Nir -- Regev, Aviv -- DP1 OD003958/OD/NIH HHS/ -- DP1 OD003958-01/OD/NIH HHS/ -- DP2 OD002230/OD/NIH HHS/ -- DP2 OD002230-01/OD/NIH HHS/ -- R21 AI071060/AI/NIAID NIH HHS/ -- R21 AI071060-01/AI/NIAID NIH HHS/ -- R21 AI71060/AI/NIAID NIH HHS/ -- S10 RR026688/RR/NCRR NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2009 Oct 9;326(5950):257-63. doi: 10.1126/science.1179050. Epub 2009 Sep 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19729616" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/*immunology ; Chromatin Assembly and Disassembly ; DNA, Single-Stranded/immunology ; Dendritic Cells/*immunology/*metabolism ; Feedback, Physiological ; Gene Expression Profiling ; *Gene Expression Regulation ; *Gene Regulatory Networks ; Inflammation/immunology/*metabolism ; Lipopeptides/immunology ; Lipopolysaccharides/immunology ; Mice ; Mice, Inbred C57BL ; Poly I-C/immunology ; RNA-Binding Proteins/metabolism ; Toll-Like Receptors/agonists ; Transcription Factors/metabolism ; Transcription, Genetic ; Viruses/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Measuring Underground-Explosion Effects on Water Levels in Surrounding Aquifers (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 7 (1969), S. 0 
    Details
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Underground detonations may produce observable effects in surrounding aquifers and wells. The nature and the duration of the effect at any observation point seem to depend on several factors such as the amount of energy released by the detonation, the geologic environment, the position of the buried explosive device in relation to the saturated zone, aquifer characteristics, and the distance from point of detonation. Precise measurement of these effects in wells presented numerous technical problems and resulted in the development of specialized techniques. Initially, these effects were observed by measuring the fluctuation of the free water surface in wells. The current technique employs high-resolution pressure transducers deep in the water column. Pneumatic packers may be used to restrict the movement of water into the well. Data are recorded on high-speed oscillographs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6584.1969.tb01283.x
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  • 6
    Electronic Resource
    Electronic Resource
    Reactions of Tetrafluorohydrazine with Di-and Triphenylphosphine. A New Method for Preparation of Fluorophosphoranes (1965)
    s.l. : American Chemical Society
    Inorganic chemistry 4 (1965), S. 765-766 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50027a042
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  • 7
    Electronic Resource
    Electronic Resource
    Role of Auxin in Growth of Inhibitor-treated Oat Coleoptile Tissue (1966)
    Oxford, UK : Blackwell Publishing Ltd
    Physiologia plantarum 19 (1966), S. 0 
    Details
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The role of auxin in the recovery of plant tissue from oxidant treatment was investigated. Treatment of oat coleoptile sections with concentrations of indoleacetic acid (IAA) or 2,4-dichlorophenoxyacetic acid (2,4-D) optimal for normal growth, following pretreatment with moderately inhibiting levels of peroxyacetyl nitrate (PAN) immediately accelerated recovery of growth rate. In some cases inhibition was also less at supraoptimal values of auxin. Treatment of ozonepretreated tissue with IAA or 2,4-D enhanced inhibition at high levels of auxin and produced an optimal growth concentration level which was lower than for sections not given ozone pretreatment. Auxin treatment also reduced the degree of inhibition in fluoride and iodoacetamide-pretreated sections. Mechanisms by which auxin-induced recovery from inhibition may occur are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3054.1966.tb07084.x
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of structure of the wear resistance of white cast iron (1968)
    Springer
    Metal science and heat treatment 10 (1968), S. 895-898 
    Details
    ISSN: 1573-8973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusions 1. No direct relationship was found between the hardness and the wear resistance of white cast irons. 2. The wear resistance of cast iron increases with the hardness of the carbides. 3. The wear resistance of hypoeutectic chromium cast irons increases linearly with the quantity of carbides if the type of carbide does not change. An increase of the carbon concentration above the eutectic does not increase the wear resistance, since large brittle needles of hypereutectic carbides are formed. 4. The wear resistance decreases with increasing sizes of the carbides. 5. The wear resistance of white cast irons increases linearly with the hardness of the metallic base. The wear resistance is highest when the metallic base is martensitic. In some cases metastable austenite provides an equal wear resistance. Stable austenite reduces the wear resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00649219
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of carbon, chromium, silicon, and molybdenum on the hardenability and wear resistance of white cast irons (1969)
    Springer
    Metal science and heat treatment 11 (1969), S. 344-346 
    Details
    ISSN: 1573-8973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusions 1. Quenching makes it possible to obtain a high wear resistance of white cast irons at a relatively low concentration of alloying elements. 2. An increase of the molybdenum concentration raises the hardenability of white cast irons, while an increase of the carbon and silicon concentrations reduces it. The silicon concentration of cast irons quenched in air should not exceed 0.7%. 3. In castings with sections up to 50 mm an increase of the molybdenum concentration above that required to obtain a martensitic—austenitic structure does not increase the wear resistance of white cast irons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00648601
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  • 10
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    Iron Uptake by Two Citrus Rootstock Species in Relation to Soil Moisture and CaCO 3 1 (1968)
    Wiley
    Details
    Publication Date: 1968-01-01
    Print ISSN: 0002-1962
    Electronic ISSN: 1435-0645
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Wiley
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