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  • Female  (2)
  • American Association for the Advancement of Science (AAAS)  (2)
  • 2005-2009  (2)
  • 1965-1969
  • 1
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    An epigenetic role for maternally inherited piRNAs in transposon silencing (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-11-29
    Description: In plants and mammals, small RNAs indirectly mediate epigenetic inheritance by specifying cytosine methylation. We found that small RNAs themselves serve as vectors for epigenetic information. Crosses between Drosophila strains that differ in the presence of a particular transposon can produce sterile progeny, a phenomenon called hybrid dysgenesis. This phenotype manifests itself only if the transposon is paternally inherited, suggesting maternal transmission of a factor that maintains fertility. In both P- and I-element-mediated hybrid dysgenesis models, daughters show a markedly different content of Piwi-interacting RNAs (piRNAs) targeting each element, depending on their parents of origin. Such differences persist from fertilization through adulthood. This indicates that maternally deposited piRNAs are important for mounting an effective silencing response and that a lack of maternal piRNA inheritance underlies hybrid dysgenesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805124/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805124/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brennecke, Julius -- Malone, Colin D -- Aravin, Alexei A -- Sachidanandam, Ravi -- Stark, Alexander -- Hannon, Gregory J -- P01 CA013106/CA/NCI NIH HHS/ -- P01 CA013106-37/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2008 Nov 28;322(5906):1387-92. doi: 10.1126/science.1165171.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory (CSHL), 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19039138" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Argonaute Proteins ; Crosses, Genetic ; *DNA Transposable Elements ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/embryology/*genetics/physiology ; *Epigenesis, Genetic ; Female ; Fertility ; Hybridization, Genetic ; Male ; Ovary/metabolism ; Peptide Initiation Factors/genetics/metabolism ; *RNA Interference ; RNA, Small Interfering/*genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Pattern separation in the human hippocampal CA3 and dentate gyrus (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-03-22
    Description: Pattern separation, the process of transforming similar representations or memories into highly dissimilar, nonoverlapping representations, is a key component of many functions ascribed to the hippocampus. Computational models have stressed the role of the hippocampus and, in particular, the dentate gyrus and its projections into the CA3 subregion in pattern separation. We used high-resolution (1.5-millimeter isotropic voxels) functional magnetic resonance imaging to measure brain activity during incidental memory encoding. Although activity consistent with a bias toward pattern completion was observed in CA1, the subiculum, and the entorhinal and parahippocampal cortices, activity consistent with a strong bias toward pattern separation was observed in, and limited to, the CA3/dentate gyrus. These results provide compelling evidence of a key role of the human CA3/dentate gyrus in pattern separation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829853/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829853/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bakker, Arnold -- Kirwan, C Brock -- Miller, Michael -- Stark, Craig E L -- P41 RR15241-01A1/RR/NCRR NIH HHS/ -- R01 EB000975/EB/NIBIB NIH HHS/ -- R01 EB000975-04/EB/NIBIB NIH HHS/ -- R01 EB008171/EB/NIBIB NIH HHS/ -- R01 EB008171-01A1/EB/NIBIB NIH HHS/ -- R01 EB00975-01/EB/NIBIB NIH HHS/ -- New York, N.Y. -- Science. 2008 Mar 21;319(5870):1640-2. doi: 10.1126/science.1152882.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18356518" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Analysis of Variance ; Brain Mapping ; Dentate Gyrus/*physiology ; Entorhinal Cortex/physiology ; Female ; Hippocampus/*physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Memory/*physiology ; Parahippocampal Gyrus/physiology ; *Pattern Recognition, Physiological
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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