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  • 1
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    beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa) (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa). Elevated concentrations of the naturally occurring opiate beta-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of beta-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary beta-endorphin may play a role in the development of the overeating and obesity syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Margules, D L -- Moisset, B -- Lewis, M J -- Shibuya, H -- Pert, C B -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):988-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Eating/drug effects ; Endorphins/antagonists & inhibitors/blood/*physiology ; Feeding Behavior/*physiology ; Female ; Male ; Mice ; Mice, Obese/*physiology ; Naloxone/pharmacology ; Obesity/genetics/*physiopathology ; Pituitary Gland/physiology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Identification of a C-glucuronide of delta6- tetrahydrocannabinol as a mouse liver conjugate in vivo (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: Delta 6-Tetrahydrocannabinol-C-4-glucuronide was found in the livers of mice that had been administered delta 6-tetrahydrocannabinol. Thus, C-glucuronidation of a compound that contains a free hydroxyl group has been demonstrated in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, S -- Yagen, B -- Mechoulam, R -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1390-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663618" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dronabinol/*analogs & derivatives/metabolism ; Glucuronates/metabolism ; Liver/*metabolism ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Antibody diversity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin-producing and uncommitted (embryonic) cells, thereby establishing the evolutionary base for generating immunoglobulin diversity. (ii) These genes exist as many small, closely related families (subgroups) that share close sequence homology largely within their own subgroup. (iii) Comparison of two cloned variable gene segments derived from a single subgroup reveals a feature of their structure that distinguishes them from fixed genes (that is, globin genes) and provides, through extensive surrounding sequence homology, a large target for intergenic recombination. This last observation suggests that a simple recombination mechanism may account for their genetic instability in both germ line and somatic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidman, J G -- Leder, A -- Nau, M -- Norman, B -- Leder, P -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):11-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Specificity ; Base Sequence ; Binding Sites, Antibody/*genetics ; Biological Evolution ; Cell Line ; Embryo, Mammalian/immunology ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Neoplasms, Experimental/immunology ; Plasmacytoma/immunology ; Recombination, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Murine teratocarcinomas were located in mice by external gamma-ray scintigraphy with an iodine-125-labeled monoclonal antibody specific to the tumors. The specificity of the method was increased by subtracting the radiation produced by an iodine-125-labeled indifferent monoclonal antibody of the same immunoglobulin class as the tumor-specific antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ballou, B -- Levine, G -- Hakala, T R -- Solter, D -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):844-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493985" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Neoplasm ; Clone Cells/immunology ; Mice ; Neoplasms, Experimental/diagnosis/immunology ; Radionuclide Imaging/*methods ; Teratoma/*diagnosis/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: A variant of the MPC 11 cell line, M 311, produces a short immunoglobulin heavy chain. When compared with the parental gamma 2b heavy chain, M 311 was found to have a carboxyl terminal deletion comprising the CH3 domain. The COOH-terminal cyanogen bromide (CNBr) cleavage fragment of M 311 is identical to a corresponding segment ofa parental heavy chain CNBr fragment, with the exception of a substitution of asparagine for lysine at the COOH-terminal residue. This observation enabled prediction of both the parental DNA sequence in this region and the genetic mechanism which generated the variant, a frameshift followed by premature termination. This hypothesis is supported by studies of the DNA sequence of the MPC 11 gamma 2b constant region gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kenter, A L -- Birshtein, B K -- R21 AI106328/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1307-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Deletion ; Genes ; Immunoglobulin G/*genetics ; Immunoglobulin gamma-Chains/genetics ; Macromolecular Substances ; Melphalan/pharmacology ; Mice ; Mutation ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/genetics ; Peptide Chain Termination, Translational ; Plasmacytoma/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    New drugs and the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):774-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/379998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; France ; History, 20th Century ; Humans ; Mice ; Psychotropic Drugs/*history/metabolism/therapeutic use ; Rats ; Schizophrenia/drug therapy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete coding sequence for the constant region of the mouse gamma 2b immunoglobulin heavy chain and the 3' untranslated region has been determined. The coding portion of the sequence is 1008 nucleotides long (amino acid residues 114 to 449), and the 3' noncoding region contains 102 nucleotides preceeding the polyadenylate. An extra carboxyl-terminal lysine residue which had not been observed in the gamma 2b or other gamma subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally. A 17-nucleotide sequence occurs with slight variation twice in CH1 and once in CH2 domains in the same relative location but with different translational phase. This sequence may be the site of crossover in a gamma 2b . gamma 2a heavy chain variant, an indication of possible recombinational activity of some kind.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Slightom, J L -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1299-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Codon ; DNA, Recombinant ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; *Protein Biosynthesis ; RNA, Messenger/*genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Hyperthermia and local anesthetics: potentiation of survival of tumor-bearing mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: Lidocaine infusion of a CA755 mammary adenocarcinoma growing in the hind leg of BDF1 mice results in a significant increase in the animals' survival when combined with heating for 1 hour in a 43.5 degrees C water bath. This ability of local anesthetics to prolong survival following hyperthermia is consistent with the hypothesis that increases in membrane fluidity influence sensitivity to heat. In view of the extensive clinical experience with local anesthetics, the delay between clinical application and the observation that they potentiate the action of hyperthermia in animals may be reduced.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yatvin, M B -- Clifton, K H -- Dennis, W H -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):195-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451588" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/therapy ; Anesthetics, Local/*therapeutic use ; Animals ; Female ; *Hot Temperature ; Lidocaine/therapeutic use ; Mammary Neoplasms, Experimental/therapy ; Membrane Fluidity/drug effects ; Mice ; Neoplasms, Experimental/*therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Role of nuclear size in cell growth initiation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Swiss 3T3 cells arrested in B0 (quiescent state) by reducing serum content of the medium all contain the same amount of DNA but vary in nuclear volume over approximately a twofold range. By use of flow microfluorimetry, scatterplots of nuclear volume versus DNA content were obtained in intervals after serum stimulation. The earliest cells to enter DNA synthesis were those with the largest nuclei, whereas cells with the smallest nuclei were among the latest. Regulation of cellular transit from G0 to the S phase was therefore, at least in part, deterministic, since all G0 cells did not have equal probabilities of entry into S at a given moment. All cells having the same nuclear volume did not initiate DNA synthesis at the same moment; therefore, factors other than nuclear volume must also influence this timing. Nuclear volume correlated with the maximum rate at which cells could enter S. The kinetic model of the cell cycle postulating a probabilistic event as solely responsible for entry into S thus appears too simple.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yen, A -- Pardee, A B -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451539" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Division ; Cell Nucleus/physiology/*ultrastructure ; Cells, Cultured/*physiology/ultrastructure ; Clone Cells/ultrastructure ; DNA/biosynthesis ; Mice
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  • 10
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    Another flame retardant, tris-(1,3-dichloro-2-propyl)-phosphate, and its expected metabolites are mutagens (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: A flame retardant used in children's sleepwear, tris-(1,3-dichloro-2-propyl)phosphate (Fyrol FR2) is a mutagen in the Salmonella-mammalian tissue homogenate test after it has been activated by mouse or rat liver homogenate. The expected enzymatic hydrolysis product, 1,3-dichloro-2-propanol, is similarly a mutagen after activation by liver homogenate. A proposed metabolite of the flame retardant, 1,3-dichloro-2-propanone, is a potent mutagen in the absence of such activation. A flame retardant with similar structure, tris-(2,3-dibromopropyl)phosphate (tris-BP), was shown previously to be a mutagen, to cause sterility in animals, to be a carcinogen, and to be absorbed through human skin. These and other flame retardants have characteristic nuclear magnetic resonance spectra that can be used to determine which flame retardant is present in commercially purchased sleepwear. Sleepwear treated with tris-BP, Fyrol FR2, and other chemical additives was being sold in late 1977.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, M D -- Blum, A -- Ames, B N -- New York, N.Y. -- Science. 1978 May 19;200(4343):785-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347576" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotransformation ; Flame Retardants/*toxicity ; Hydrocarbons, Chlorinated/toxicity ; Liver/metabolism ; Mice ; *Mutagens ; Organophosphorus Compounds/*toxicity ; Salmonella typhimurium/drug effects ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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