Publication Date:
2006-09-30
Description:
To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lamb, Justin -- Crawford, Emily D -- Peck, David -- Modell, Joshua W -- Blat, Irene C -- Wrobel, Matthew J -- Lerner, Jim -- Brunet, Jean-Philippe -- Subramanian, Aravind -- Ross, Kenneth N -- Reich, Michael -- Hieronymus, Haley -- Wei, Guo -- Armstrong, Scott A -- Haggarty, Stephen J -- Clemons, Paul A -- Wei, Ru -- Carr, Steven A -- Lander, Eric S -- Golub, Todd R -- New York, N.Y. -- Science. 2006 Sep 29;313(5795):1929-35.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA. justin@broad.mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17008526" target="_blank"〉PubMed〈/a〉
Keywords:
Alzheimer Disease/drug therapy/genetics
;
Cell Line
;
Cell Line, Tumor
;
*Databases, Factual
;
Dexamethasone/pharmacology/therapeutic use
;
Drug Evaluation, Preclinical/*methods
;
Drug Resistance, Neoplasm
;
Enzyme Inhibitors/pharmacology
;
Estrogens/pharmacology
;
Gene Expression/*drug effects
;
*Gene Expression Profiling
;
HSP90 Heat-Shock Proteins/antagonists & inhibitors
;
Histone Deacetylase Inhibitors
;
Humans
;
Limonins/pharmacology
;
Obesity/genetics/physiopathology
;
Oligonucleotide Array Sequence Analysis
;
Phenothiazines/pharmacology
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug
;
therapy/genetics/physiopathology
;
Sirolimus/pharmacology/therapeutic use
;
Software
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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