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  • Gas chromatography  (36)
  • lipid peroxidation  (34)
  • Springer  (70)
  • 2005-2009
  • 1985-1989  (42)
  • 1980-1984  (28)
  • 1965-1969
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  • 1
    Electronic Resource
    Electronic Resource
    In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 882-886 
    Details
    ISSN: 1420-9071
    Keywords: Lipopeptides ; immunomodulation ; cytochrome P-450 ; lipid peroxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunomodulating lipopeptides lauroyl-L-Ala-γ-D-Glu-LL-A2pmNH2-Gly (RP 44.102) and lauroyl-L-Ala-γ-D-Glu-LL-A2pmNH2 (RP 56.142) were found to protect mice against the hepatotoxicity of paracetamol, which is due to cytochrome P-450 dependent formation of toxic metabolites and radicals. In fact they decreased the amount of hepatic microsomal cytochrome P-450, and the level of CCl4-induced lipid peroxidation. In contrast lauroyl-L-Ala-γ-D-Glu-DD-A2pmNH2 (RP 53.204), which only differs by the configuration of the two chiral carbons of A2pm (diaminopimelic acid) and is not an immunomodulating agent, failed to protect against poisoning by paracetamol and had no effect on the level of hepatic cytochrome P-450 or the microsomal CCl4-induced lipid peroxidation. This provides a clear connection between the immunostimulating properties of a compound and its effects on xenobiotic biotransformations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954064
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  • 2
    Electronic Resource
    Electronic Resource
    Chemically modified teflon capillary columns for gas chromatography II. Solid surface effects in direct coated columns (1982)
    Springer
    Chromatographia 15 (1982), S. 641-644 
    Details
    ISSN: 1612-1112
    Keywords: Teflon capillary columns ; Chemically modified teflon ; Gas chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The preparation of teflon capillary columns employing direct coating of the stationary phase to the chemically modified teflon surface and the role of the chemically modified teflon in the separation mechanism are described. Two types of contributions from the modified teflon have been observed: nonspecific adsorption of the carbon surface and specific interactions of polar groups in the carbon skeleton. The use of polar liquid phases can eliminate adsorption due to the presence of polar groups in the modified teflon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279491
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  • 3
    Electronic Resource
    Electronic Resource
    Trace determination of amines and other nitrogen containing compounds with a modiefied thermal energy analyzer (TEATM) (1982)
    Springer
    Chromatographia 16 (1982), S. 354-358 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Modified thermal energy analyzer ; Selective detection of nitrogen compounds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A modification to the TEATM Analyzer is described, which allows it to be used as a highly selective GC detector for nitrogen compounds as well as for N-nitrosamines and nitro compounds. The modified Analyzer is as sensitive as the AFID, but has a much higher selectivity towards nitrogen compounds than the AFID. Its response appears to be molar, with an output that is dependent only on the number of nitrogen atoms present. The performance of the modified Analyzer for the analysis of ammonia, amines,N-nitrosamines, nitriles and organonitro compounds is reported and discussed, as is its application to the detection of these compounds in bacon and beer samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02258937
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  • 4
    Electronic Resource
    Electronic Resource
    Modification of supports with liquid phases by thermal treatment in a closed system (1985)
    Springer
    Chromatographia 20 (1985), S. 228-230 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Modified diatomaceous supports
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Diatomaceous earth type supports are modified with a liquid phase, by high-temperature thermal treatment in a closed system. It is shown that the retention characteristics of the support changes by this treatment. The main advantage of this method, as compared with modification in a flow-through system is that liquid phase evaporation and possibility of oxydation during the process can be avoided. This ensures a better uniformity of the modified support.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02259692
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of chronic ethanol treatment on peroxisomal acyl-CoA oxidase activity and lipid peroxidation in rat liver and heart (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 580-581 
    Details
    ISSN: 1420-9071
    Keywords: Ethanol ; peroxisomes ; lipid peroxidation ; alcoholic cardiomyopathy ; rat liver ; rat heart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chronic ethanol administration was shown to increase catalase and acyl-CoA oxidase activities in rat myocardium but did not alter the activity of liver peroxisomal enzymes. As a result of alcohol consumption a 2–3-fold increase in the level of lipid peroxidation was observed in the heart tissue while in the liver the induction was much less pronounced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02143593
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  • 6
    Electronic Resource
    Electronic Resource
    Antioxidant enzyme alterations in experimental and clinical diabetes (1988)
    Springer
    Molecular and cellular biochemistry 84 (1988), S. 223-231 
    Details
    ISSN: 1573-4919
    Keywords: Diabetic rat ; lipid peroxidation ; oxidative stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Previous studies from our laboratory have demonstrated the presence of complex alterations in the activities of antioxidant enzymes in various tissues of rats with streptozotocin (STZ)-induced diabetes. In the present investigation, it is shown that rats made diabetic with alloxan (ALX), an agent differing from STZ both chemically and in its mechanism of diabetogenesis, show virtually identical tissue antioxidant enzyme changes which, as is the case with STZ, are preventable by insulin treatment. The finding that the patterns of antioxidant enzyme alterations in chemically-induced diabetes are independent of the diabetogenic agent used and the presence of similar abnormalities in tissues of spontaneously diabetic (BB) Wistar rats (particularly when diabetic control is less than optimal) suggest that the changes observed are a characteristic feature of the uncontrolled diabetic state and that these may be responsible for (or predispose to) the development of secondary complications in clinical diabetes. Comparative studies involving red cells of diabetic rats and human diabetics revealed a number of common changes, namely an increase in glutathione reductase activity, a decreased susceptibility to oxidative glutathione depletion (which was related to the presence of hyperglycemia) and an increased production of malondialdehyde (an indirect index of lipid peroxidation) in response to in vitro challenge with hydrogen peroxide. In the diabetic patients, the extent of this increase in susceptibility of red cell lipids to oxidation paralleled the severity of diabetic complications. Our results suggest that increased (or uncontrolled) oxidative activity may play an important role in the pathogenesis of complications associated with the chronic diabetic state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421057
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  • 7
    Electronic Resource
    Electronic Resource
    Ultrastructural and gas-chromatographic analysis of the preputial glands of male nude (nu/nu) mice (1980)
    Springer
    Cell & tissue research 211 (1980), S. 73-82 
    Details
    ISSN: 1432-0878
    Keywords: Preputial glands ; Nude mice ; Ultrastructure ; Gas chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The preputial glands of male nude (nu/nu) mice were analyzed by a combination of electron microscopy and gas chromatography to determine whether or not they are affected, like developing hairs and nails, by the nu/nu genotype. Results of the analyses revealed no differences between the glands of nude and normal male mice in either their ultrastructural characteristics or lipid secretory products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233724
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  • 8
    Electronic Resource
    Electronic Resource
    Chemically modified teflon wall-coated open tubular columns for gas chromatography (1981)
    Springer
    Chromatographia 14 (1981), S. 19-22 
    Details
    ISSN: 1612-1112
    Keywords: Teflon columns ; Chemically modified teflon ; Gas chromatography ; Capillary columns
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Wall-coated open tubular columns prepared from chemically modified teflon tubing have been developed for gas chromatography. Chemical reaction of the inner walls of teflon tubing allows bonding of an adhesive layer on which a variety of stationary phaes can be coated. Test mixtures of alkanes and alcohols were used to investigate the chromatographic properties of these columns and the stability and mixing of the adhesive and stationary phae layers. the results in dicate that mixing of the layers is negligible and that the column is stable for a long period of time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02262057
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  • 9
    Electronic Resource
    Electronic Resource
    Relationship between the average molecular polarizabilities of polycyclic aromatic hydrocarbons and their retention indices determined on various stationary phases (1983)
    Springer
    Chromatographia 17 (1983), S. 300-302 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Average molecular polarizability ; Retention index ; Polycyclic aromatic hydrocarbons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The Kováts retention indices of 10 polycyclic aromatic hydrocarbons were determined on SE-30, OV-101, SE-52, OV-7 and OV-17 stationary phases. A significant correlation has been found between the retention indices and the average molecular polarizabilities of the analyzed substances. Equations were derived for the direct determination of the average molecular polarizabilities from the retention index values. The influence of the temperature on this relationship is also indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02270661
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  • 10
    Electronic Resource
    Electronic Resource
    Mixed micropacked columns designed for selective separation of fermentation products (1986)
    Springer
    Chromatographia 22 (1986), S. 358-362 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Micropacked columns ; Quantitation ; Fermentation products
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A new method is proposed for the analysis by gas chromatography of volatile compounds found in alcoholic and acetic fermentation samples. The method represents a suitable choice for the accurate and precise determination of 19 compounds (including Methanol) by direct injection onto a single column. Chromatograms of synthetic mixtures as well as actual samples show the capabilities of the micropacked column used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02268790
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