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  • Astronomy  (11)
  • Aerospace Medicine  (2)
  • Mice
  • Nitric Oxide Synthase
  • 2005-2009  (10)
  • 1990-1994  (5)
  • 1
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    Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-09-23
    Description: The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments. In mutant mice deficient in neuronal NO synthase (NOS) activity, infarct volumes decreased significantly 24 and 72 hours after middle cerebral artery occlusion, and the neurological deficits were less than those in normal mice. This result could not be accounted for by differences in blood flow or vascular anatomy. However, infarct size in the mutant became larger after endothelial NOS inhibition by nitro-L-arginine administration. Hence, neuronal NO production appears to exacerbate acute ischemic injury, whereas vascular NO protects after middle cerebral artery occlusion. The data emphasize the importance of developing selective inhibitors of the neuronal isoform.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, Z -- Huang, P L -- Panahian, N -- Dalkara, T -- Fishman, M C -- Moskowitz, M A -- NS10828/NS/NINDS NIH HHS/ -- NS2636/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1994 Sep 23;265(5180):1883-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stroke Research Laboratory, Massachusetts General Hospital, Charlestown 02129.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7522345" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Oxidoreductases/antagonists & inhibitors/deficiency/*metabolism ; Animals ; Arginine/analogs & derivatives/pharmacology ; Brain/enzymology/*metabolism ; Brain Ischemia/complications/*metabolism ; Cerebral Infarction/*etiology ; Cerebrovascular Circulation ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Neurons/*enzymology ; Nitric Oxide/*metabolism ; Nitric Oxide Synthase ; Nitroarginine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-07-22
    Description: Long-term potentiation (LTP) is a persistent increase in synaptic strength implicated in certain forms of learning and memory. In the CA1 region of the hippocampus, LTP is thought to involve the release of one or more retrograde messengers from the postsynaptic cell that act on the presynaptic terminal to enhance transmitter release. One candidate retrograde messenger is the membrane-permeant gas nitric oxide (NO), which in the brain is released after activation of the neuronal-specific NO synthase isoform (nNOS). To assess the importance of NO in hippocampal synaptic plasticity, LTP was examined in mice where the gene encoding nNOS was disrupted by gene targeting. In nNOS- mice, LTP induced by weak intensity tetanic stimulation was normal except for a slight reduction in comparison to that in wild-type mice and was blocked by NOS inhibitors, just as it was in wild-type mice. Immunocytochemical studies indicate that in the nNOS- mice as in wild-type mice, the endothelial form of NOS (eNOS) is expressed in CA1 neurons. These findings suggest that eNOS, rather than nNOS, generates NO within the postsynaptic cell during LTP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Dell, T J -- Huang, P L -- Dawson, T M -- Dinerman, J L -- Snyder, S H -- Kandel, E R -- Fishman, M C -- DA-00074/DA/NIDA NIH HHS/ -- DA-00266/DA/NIDA NIH HHS/ -- MH-45923/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1994 Jul 22;265(5171):542-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7518615" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Oxidoreductases/antagonists & inhibitors/genetics/*metabolism ; Animals ; Arginine/*analogs & derivatives/pharmacology ; Electric Stimulation ; Endothelium/enzymology ; Hippocampus/drug effects/enzymology/*physiology ; In Vitro Techniques ; *Long-Term Potentiation/drug effects ; Mice ; Mutation ; Nitric Oxide/*metabolism ; Nitric Oxide Synthase ; Nitroarginine ; Pyramidal Cells/drug effects/enzymology/*physiology ; Synaptic Transmission/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Gamma-ray Bursts: The Prompt Emission (2005)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: Gamma-ray bursts are the largest explosions in the Universe. The radiation is thought to come from a hypernova initiated from the collapse of a massive star or perhaps the merger of two compact stars such s neutron stars and/or black holes. Most of the observed energy is radiated as gamma rays, usually lasting from a fraction of a second to several hundred seconds. The energy generation process is usually referred to as the "central engine". Observed properties of this prompt emission, including spectra, time profiles and durations will be discussed. The history of these observations and future GRB spacecraft will also be described.
    Keywords: Astronomy
    Type: AAVSO-HEA3 , The 3rd American Association of Variable Star Obervers High Energy Astrophysics Workshop; Mar 21, 2005; Las Cruces, NM; United States
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  • 4
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    LDEF radiation measurements: preliminary results (1992)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The Long Duration Exposure Facility (LDEF), retrieved by the Space Shuttle mission STS-32 after nearly 6 yr in orbit, is the focus of a broad-based study of the radiation environment in low Earth orbit (LEO) and its effects on materials. A combination of passive techniques has been used to study this environment via detectors which were contained in experiments aboard the LDEF spacecraft and through analysis of induced radioactivities. Preliminary results for absorbed dose measurements and for induced activities in various materials are presented. A number of effects have been observed which reflect the anisotropy of the charged particle flux in low Earth orbit. Quantitative results from these measurements should provide an accurate means of confirming environmental flux models and techniques for predicting radiation encountered in future LEO missions, particularly those of extended duration.
    Keywords: Aerospace Medicine
    Type: International Journal Of Radiation Applications And Instrumentation. Part D, Nuclear Tracks And Radiation Measurements (ISSN 0735-245X); 20; 1; 131-6
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  • 5
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    The EXIST Mission Concept Study (2008)
    In:  Other Sources
    Details
    Publication Date: 2019-07-19
    Description: EXIST is a mission designed to find and study black holes (BHs) over a wide range of environments and masses, including: 1) BHs accreting from binary companions or dense molecular clouds throughout our Galaxy and the Local Group, 2) supermassive black holes (SMBHs) lying dormant in galaxies that reveal their existence by disrupting passing stars, and 3) SMBHs that are hidden from our view at lower energies due to obscuration by the gas that they accrete. 4) the birth of stellar mass BHs which is accompanied by long cosmic gamma-ray bursts (GRBs) which are seen several times a day and may be associated with the earliest stars to form in the Universe. EXIST will provide an order of magnitude increase in sensitivity and angular resolution as well as greater spectral resolution and bandwidth compared with earlier hard X-ray survey telescopes. With an onboard optical-infra red (IR) telescope, EXIST will measure the spectra and redshifts of GRBs and their utility as cosmological probes of the highest z universe and epoch of reionization. The mission would retain its primary goal of being the Black Hole Finder Probe in the Beyond Einstein Program. However, the new design for EXIST proposed to be studied here represents a significant advance from its previous incarnation as presented to BEPAC. The mission is now less than half the total mass, would be launched on the smallest EELV available (Atlas V-401) for a Medium Class mission, and most importantly includes a two-telescope complement that is ideally suited for the study of both obscured and very distant BHs. EXIST retains its very wide field hard X-ray imaging High Energy Telescope (HET) as the primary instrument, now with improved angular and spectral resolution, and in a more compact payload that allows occasional rapid slews for immediate optical/IR imaging and spectra of GRBs and AGN as well as enhanced hard X-ray spectra and timing with pointed observations. The mission would conduct a 2 year full sky survey in scanning mode, interrupted for several orbits per day by GRB follow-ups, followed by a combined pointing-scanning mission phase for optical/IR spectroscopy and redshifts for the large AGN sample found in the survey as well as GRBs and LSST transients. A Team of university, NASA, and industry investigators will conduct the study to determine the full sensitivity and capabilities of this new configuration for EXIST. It will build on the extensive studies of the prior design for the mission and the HET and will incorporate the optical/IR telescope (hereafter IRT) now fully developed by our ITT partner for the NextView Commercial Remote Sensing mission (early 2008 launch) with a focal plane to be developed at GSFC based in part on JWST/NIRSPEC designs. No new technology is needed for either the IRT or HET instruments. The study will pay close attention to full mission cost and present a design for the Decadal Survey Workshop to ensure this even more capable EXIST mission is once again part of the next Decadal Survey.
    Keywords: Astronomy
    Type: MSFC-2072 , INTEGRAL Conference; Sep 07, 2008 - Sep 12, 2008; Copenhagen; Denmark
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  • 6
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    Particle Acceleration, Magnetic Field Generation and Emission from Relativistic Jets and Supernova Remnants (2006)
    In:  Other Sources
    Details
    Publication Date: 2019-07-19
    Description: We performed numerical simulations of particle acceleration, magnetic field generation, and emission from shocks in order to understand the observed emission from relativistic jets and supernova remnants. The investigation involves the study of collisionless shocks, where the Weibel instability is responsible for particle acceleration as well as magnetic field generation. A 3-D relativistic particle-in-cell (RPIC) code has been used to investigate the shock processes in electron-positron plasmas. The evolution of theWeibe1 instability and its associated magnetic field generation and particle acceleration are studied with two different jet velocities (0 = 2,5 - slow, fast) corresponding to either outflows in supernova remnants or relativistic jets, such as those found in AGNs and microquasars. Slow jets have intrinsically different structures in both the generated magnetic fields and the accelerated particle spectrum. In particular, the jet head has a very weak magnetic field and the ambient electrons are strongly accelerated and dragged by the jet particles. The simulation results exhibit jitter radiation from inhomogeneous magnetic fields, generated by the Weibel instability, which has different spectral properties than standard synchrotron emission in a homogeneous magnetic field.
    Keywords: Astronomy
    Type: 6th INTEGRAL Workshop: The Obscured Universe; Jul 02, 2006 - Jul 08, 2006; Moscow; Russia
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  • 7
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    Don Clayton and Nuclear Gamma-Ray Astronomy (2005)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: For over four decades, Don Clayton has been a driving force in nuclear gamma-ray astronomy. During the 1960's, he published the first papers that gave us the scientific objectives for many balloon-borne and satellite-borne observations to come. He inspired others to work in this field as both theorists and observers. Later, he was a strong advocate for a major observatory; he helped get the Compton Gamma Ray Observatory off the ground. Over the years, he has advised and mentored many who are now among the leaders in our field. I will attempt to summarize his many contributions to theory and the interpretation of observations in this field.
    Keywords: Astronomy
    Type: Astronomy with Radioactivities; Sep 05, 2005 - Sep 09, 2005; Clemson, SC; United States
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  • 8
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    Relativistic MHD Simulations of Precessed Jets (2006)
    In:  Other Sources
    Details
    Publication Date: 2019-07-19
    Description: Relativistic jets are considered to be generated by magnetic fields in a rotating black hole with accretion disk. Consequently, resulting outflows contain magnetic fields in them and control the propagation of jets. We have performed 3D relativistic MHD simulations to investigate the stability and structure of precessed MHD jets with large Lorentz factor by using a newly developed 3D GRMHD code. We have performed simulations of supermagnetosonic jets surrounded by a fast wind. The simulation results reveal complex pressure structure inside the RMHD jet. The structure is produced by a combination of the helical surface and body modes excited by the precession as predicted theoretically. The wavelength of the body mode which occurs in an internal helical twist is much shorter than that of the helical twist surface mode. We will present some comparisons between the RMHD simulations and theoretical predictions, and potential observables and discuss the effect of wind.
    Keywords: Astronomy
    Type: Microquasars and Beyond; Sep 18, 2006 - Sep 22, 2006; Como; Italy
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  • 9
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    Ionizing radiation exposure of LDEF (pre-recovery estimates) (1992)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The long duration exposure facility (LDEF), launched into a 258 nautical mile orbit with an inclination of 28.5 degrees, remained in space for nearly 6 yr. The 21,500 lb NASA satellite was one of the largest payloads ever deployed by the Space Shuttle. LDEF completed 32,422 orbits and carried 57 major experiments representing more than 200 investigators from 33 private companies, 21 universities and nine countries. The experiments covered a wide range of disciplines including basic science, electronics, optics, materials, structures and power and propulsion. A number of the experiments were specifically designed to measure the radiation environment. These experiments are of specific interest, since the LDEF orbit is essentially the same as that of the Space Station Freedom. Consequently, the radiation measurements on LDEF will play a significant role in the design of radiation shielding of the space station. The contributions of the various authors presented here attempt to predict the major aspects of the radiation exposure received by the various LDEF experiments and therefore should be helpful to investigators who are in the process of analyzing experiments which may have been affected by exposure to ionizing radiation. The paper discusses the various types and sources of ionizing radiation including cosmic rays, trapped particles (both protons and electrons) and secondary particles (including neutrons, spallation products and high-LET recoils), as well as doses and LET spectra as a function of shielding. Projections of the induced radioactivity of LDEF are also discussed.
    Keywords: Aerospace Medicine
    Type: International Journal Of Radiation Applications And Instrumentation. Part D, Nuclear Tracks And Radiation Measurements (ISSN 0735-245X); 20; 1; 75-100
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  • 10
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    A Maskless Gamma-Ray All-Sky Imager: BATSE/CGRO (1994)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The non-collimated detectors of BATSE (Burst And Transient Source Experiment) on the Compton Gamma Ray Observatory (CGRO) can be used as a high sensitivity hard X-ray and low energy gamma-ray all-sky imager in the energy range between 20 keV and 2 MeV. The fluxes from sources in the sky are modulated as the spacecraft orbits the Earth. The CGRO orbital precession further allows sampling of sky in strips corresponding to the limb of the earth at any given time. The modulation data are transformed into images by various reconstruction methods. High sensitivity images of location accuracy of about 0.1 deg and source seperation of about 1 deg are obtained.
    Keywords: Astronomy
    Type: NASA-CR-204027 , NAS 1.26:204027 , IEEE Transactions on Nuclear Science (ISSN 0018-9499); 41; 4; 1313-1320
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