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  • Mutation  (6)
  • 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology  (3)
  • 2005-2009  (6)
  • 2000-2004  (3)
  • 1
    Electronic Resource
    Electronic Resource
    A novel HLA-A*6816 allele possibly generated by a point mutation in a Chilean from Punta Arenas (Magellan Strait) (2000)
    Springer
    Immunogenetics 51 (2000), S. 257-260 
    Details
    ISSN: 1432-1211
    Keywords: Key words Amerindians ; Chileans ; HLA-A*6816 ; Mutation ; Gene conversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050618
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  • 2
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    Strigolactone inhibition of shoot branching (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-08-12
    Description: A carotenoid-derived hormonal signal that inhibits shoot branching in plants has long escaped identification. Strigolactones are compounds thought to be derived from carotenoids and are known to trigger the germination of parasitic plant seeds and stimulate symbiotic fungi. Here we present evidence that carotenoid cleavage dioxygenase 8 shoot branching mutants of pea are strigolactone deficient and that strigolactone application restores the wild-type branching phenotype to ccd8 mutants. Moreover, we show that other branching mutants previously characterized as lacking a response to the branching inhibition signal also lack strigolactone response, and are not deficient in strigolactones. These responses are conserved in Arabidopsis. In agreement with the expected properties of the hormonal signal, exogenous strigolactone can be transported in shoots and act at low concentrations. We suggest that endogenous strigolactones or related compounds inhibit shoot branching in plants. Furthermore, ccd8 mutants demonstrate the diverse effects of strigolactones in shoot branching, mycorrhizal symbiosis and parasitic weed interaction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gomez-Roldan, Victoria -- Fermas, Soraya -- Brewer, Philip B -- Puech-Pages, Virginie -- Dun, Elizabeth A -- Pillot, Jean-Paul -- Letisse, Fabien -- Matusova, Radoslava -- Danoun, Saida -- Portais, Jean-Charles -- Bouwmeester, Harro -- Becard, Guillaume -- Beveridge, Christine A -- Rameau, Catherine -- Rochange, Soizic F -- England -- Nature. 2008 Sep 11;455(7210):189-94. doi: 10.1038/nature07271.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Universite de Toulouse, UPS, CNRS, Surface Cellulaire et Signalisation chez les Vegetaux, 24 chemin de Borde Rouge, F-31326 Castanet-Tolosan, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18690209" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/drug effects/genetics/growth & development ; Arabidopsis Proteins/genetics/metabolism ; Dioxygenases ; Genes, Plant/genetics ; Lactones/analysis/chemistry/*metabolism/pharmacology ; Mutation ; Mycorrhizae/physiology ; Oxygenases/genetics/metabolism ; Peas/drug effects/growth & development/*metabolism/parasitology ; Phenotype ; Plant Growth Regulators/analysis/chemistry/*metabolism/pharmacology ; Plant Proteins/genetics/metabolism ; Plant Roots/drug effects/metabolism ; Plant Shoots/drug effects/*growth & development/*metabolism/parasitology ; Symbiosis ; Terpenes/analysis/chemistry/metabolism/pharmacology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Engineering modified Bt toxins to counter insect resistance (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-11-03
    Description: The evolution of insect resistance threatens the effectiveness of Bacillus thuringiensis (Bt) toxins that are widely used in sprays and transgenic crops. Resistance to Bt toxins in some insects is linked with mutations that disrupt a toxin-binding cadherin protein. We show that susceptibility to the Bt toxin Cry1Ab was reduced by cadherin gene silencing with RNA interference in Manduca sexta, confirming cadherin's role in Bt toxicity. Native Cry1A toxins required cadherin to form oligomers, but modified Cry1A toxins lacking one alpha-helix did not. The modified toxins killed cadherin-silenced M. sexta and Bt-resistant Pectinophora gossypiella that had cadherin deletion mutations. Our findings suggest that cadherin promotes Bt toxicity by facilitating toxin oligomerization and demonstrate that the modified Bt toxins may be useful against pests resistant to standard Bt toxins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soberon, Mario -- Pardo-Lopez, Liliana -- Lopez, Idalia -- Gomez, Isabel -- Tabashnik, Bruce E -- Bravo, Alejandra -- 1R01 AI066014/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2007 Dec 7;318(5856):1640-2. Epub 2007 Nov 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apartado Postal 510-3, Cuernavaca 62250, Morelos, Mexico. mario@ibt.unam.mx〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17975031" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Proteins/chemistry/*genetics/metabolism/*toxicity ; Bacterial Toxins/chemistry/*genetics/metabolism/*toxicity ; Cadherins/genetics/metabolism ; Endotoxins/chemistry/*genetics/metabolism/*toxicity ; Genetic Engineering ; Hemolysin Proteins/chemistry/*genetics/metabolism/*toxicity ; *Insecticide Resistance ; Larva ; *Manduca/genetics/metabolism ; *Moths/genetics/metabolism ; Mutation ; *Pest Control, Biological ; RNA Interference
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Protection of C. elegans from anoxia by HYL-2 ceramide synthase (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-18
    Description: Oxygen deprivation is rapidly deleterious for most organisms. However, Caenorhabditis elegans has developed the ability to survive anoxia for at least 48 hours. Mutations in the DAF-2/DAF-16 insulin-like signaling pathway promote such survival. We describe a pathway involving the HYL-2 ceramide synthase that acts independently of DAF-2. Loss of the ceramide synthase gene hyl-2 results in increased sensitivity of C. elegans to anoxia. C. elegans has two ceramide synthases, hyl-1 and hyl-2, that participate in ceramide biogenesis and affect its ability to survive anoxic conditions. In contrast to hyl-2(lf) mutants, hyl-1(lf) mutants are more resistant to anoxia than normal animals. HYL-1 and HYL-2 have complementary specificities for fatty acyl chains. These data indicate that specific ceramides produced by HYL-2 confer resistance to anoxia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Menuz, Vincent -- Howell, Kate S -- Gentina, Sebastien -- Epstein, Sharon -- Riezman, Isabelle -- Fornallaz-Mulhauser, Monique -- Hengartner, Michael O -- Gomez, Marie -- Riezman, Howard -- Martinou, Jean-Claude -- New York, N.Y. -- Science. 2009 Apr 17;324(5925):381-4. doi: 10.1126/science.1168532.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, University of Geneva, CH-1211 Geneva 4, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19372430" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Caenorhabditis elegans/cytology/genetics/*physiology ; Caenorhabditis elegans Proteins/*genetics/*metabolism ; *Cell Hypoxia ; Ceramides/biosynthesis/*physiology ; Gene Deletion ; Genes, Helminth ; Mutation ; Oxidoreductases/*genetics/*metabolism ; Oxygen/*physiology ; Receptor, Insulin/genetics/metabolism ; Saccharomyces cerevisiae/genetics/growth & development/physiology ; Sphingomyelins/biosynthesis/physiology ; Substrate Specificity ; Transformation, Genetic ; Transgenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Selective trafficking of non-cell-autonomous proteins mediated by NtNCAPP1 (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-01-18
    Description: In plants, cell-to-cell communication is mediated by plasmodesmata and involves the trafficking of non-cell-autonomous proteins (NCAPs). A component in this pathway, Nicotiana tabacum NON-CELL-AUTONOMOUS PATHWAY PROTEIN1 (NtNCAPP1), was affinity purified and cloned. Protein overlay assays and in vivo studies showed that NtNCAPP1 is located on the endoplasmic reticulum at the cell periphery and displays specificity in its interaction with NCAPs. Deletion of the NtNCAPP1 amino-terminal transmembrane domain produced a dominant-negative mutant that blocked the trafficking of specific NCAPs. Transgenic tobacco plants expressing this mutant form of NtNCAPP1 and plants in which the NtNCAPP1 gene was silenced were compromised in their ability to regulate leaf and floral development. These results support a model in which NCAP delivery to plasmodesmata is both selective and regulated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Jung-Youn -- Yoo, Byung-Chun -- Rojas, Maria R -- Gomez-Ospina, Natalia -- Staehelin, L Andrew -- Lucas, William J -- GM18639/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2003 Jan 17;299(5605):392-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Plant Biology, Division of Biological Sciences, University of California, 1 Shields Avenue, Davis, CA 95616, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12532017" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Cell Communication ; Cell Line ; Cloning, Molecular ; Cytoplasm/metabolism ; Endoplasmic Reticulum/metabolism ; Flowers/growth & development ; Gene Silencing ; Green Fluorescent Proteins ; Immunohistochemistry ; Luminescent Proteins/metabolism ; Molecular Sequence Data ; Mutation ; Phenotype ; Plant Leaves/growth & development ; Plant Proteins/chemistry/genetics/*isolation & purification/*metabolism ; Plants, Genetically Modified ; Plasmodesmata/*metabolism ; Protein Transport ; Recombinant Fusion Proteins/metabolism ; Tobacco/genetics/growth & development/*metabolism ; Tobacco Mosaic Virus ; Viral Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-13
    Description: We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained suppression of viremia, preserving CD4 levels and permitting the induction of virus-specific cellular immunity. L-870812 was also active in chronic infection; however, the magnitude and durability of the effect varied in conjunction with the pretreatment immune response and viral load. These studies demonstrate integrase inhibitor activity in vivo and suggest that cellular immunity facilitates chemotherapeutic efficacy in retroviral infections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hazuda, Daria J -- Young, Steven D -- Guare, James P -- Anthony, Neville J -- Gomez, Robert P -- Wai, John S -- Vacca, Joseph P -- Handt, Larry -- Motzel, Sherri L -- Klein, Hilton J -- Dornadula, Geethanjali -- Danovich, Robert M -- Witmer, Marc V -- Wilson, Keith A A -- Tussey, Lynda -- Schleif, William A -- Gabryelski, Lori S -- Jin, Lixia -- Miller, Michael D -- Casimiro, Danilo R -- Emini, Emilio A -- Shiver, John W -- New York, N.Y. -- Science. 2004 Jul 23;305(5683):528-32. Epub 2004 Jul 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, Merck Research Laboratories, Post Office Box 4, West Point, PA 19486, USA. daria_hazuda@merck.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15247437" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*drug therapy/*immunology/virology ; Animals ; Anti-HIV Agents/administration & dosage/blood/pharmacology/therapeutic use ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Drug Resistance, Viral ; HIV Integrase/genetics/metabolism ; HIV Integrase Inhibitors/administration & dosage/blood/pharmacology/therapeutic ; use ; HIV-1/drug effects/enzymology/genetics/*physiology ; Immunity, Cellular ; Integrase Inhibitors/administration & dosage/blood/pharmacology/*therapeutic use ; Integrases/genetics/metabolism ; Leukocytes, Mononuclear/virology ; Macaca mulatta ; Mutation ; Naphthyridines/administration & dosage/blood/pharmacology/*therapeutic use ; Simian Acquired Immunodeficiency Syndrome/*drug therapy/*immunology/virology ; Simian Immunodeficiency Virus/drug effects/enzymology/genetics/*physiology ; Viral Load ; Viremia/drug therapy ; Virus Replication/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Unusual seismic signals associated with the activity at Galeras volcano, Colombia, from July 1992 to September 1994 (2006)
    Details
    Publication Date: 2019-11-04
    Description: After the emplacement of a lava dome at Galeras volcano in 1991, seven eruptions occurred from July 16, 1992, to September 23, 1994, six of which were preceded by quasi-monochromatic, long-duration seismic events with slowly decaying coda named «tornillos» (screws). The dominant frequencies of these unusual seismic signals are related to source characteristics and show temporal changes, diminishing and then tending to stabilize before an eruption. At the same time, the accumulated number and the duration of these signals increase several days prior to the eruption. The increase in the duration of the tornillo events and the decline of the dominant frequencies both suggest an increasing impedance contrast between the surrounding solid material and the fluid. These characteristics may be associated with an increase in the free gas phase in the magma produced by saturation of volatiles due to cooling, crystallization and partial solidification of the column of magma plugging the conduits. The solidified magma can contribute to sealing the conduits and preventing free gas escape, with consequent generation of overpressure. An eruption is initiated when the overpressure exceeds the resistance strength of the solid material.
    Description: JCR Journal
    Description: open
    Keywords: Galeras ; tornillo events ; seismic signals ; eruptions ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 8
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    The anatomy of a tornillo: puzzles from three-component measurements at Galeras volcano (Colombia) (2006)
    Details
    Publication Date: 2019-11-04
    Description: Many of the recent ash eruptions of Galeras volcano (Colombia) have been preceded by tornillos. These unusual seismic events of unknown origin have screw-like profiles on seismograms and can last up to several minutes. In March, 1996, a broadband, three-component seismometer station was installed 1.6 km south of Cono, Galeras' active vent. With high quality recordings acquired by this system, and methods which work well with narrow band signals, we investigate the frequency content and polarization properties of two tornillos. They have slighty different predominant frequencies, 3.0420 Hz and 3.0595 Hz which remain highly stable for the entire tornillo duration. The polarization analysis shows that the polarization for the two events also differs slightly but remains constant. Most of their energy is linearly polarized and lies in the horizontal plane. If these waves are taken to be SH waves, the remaining energy is confined to the beginning of the tornillo during its initiation or excitation. The remainder of the tornillo is characterized by exponential decay. These observations provide parameters for the classification of tornillos and constraints for source models.
    Description: JCR Journal
    Description: open
    Keywords: Galeras ; tornillo ; polarizations ; analytic function ; parametrization ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 9
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    Tornillo seismic events at Galeras volcano, Colombia: a summary and new information from broadband three-component measurements (2006)
    Details
    Publication Date: 2019-11-04
    Description: Long-duration events have been recorded at several active, andesitic volcanoes. Their main characteristics are a single, sharp frequency peak, and an exceptionally long coda. Because their seismograms resemble a screw, these signals are called "tornillos" in Colombia. These events have been recorded during different stages of volcanic activity at various volcanoes worldwide. Tornillos have occurred for example, as a short-term precursor to eruptions at Galeras volcano, Colombia (1992-1993); and at Asama volcano, Japan, (1983). At Tokachi volcano, Japan, they were recorded after an eruption (1989). The Tornillo's dominant frequency appears to be related to the time of occurrence during an eruption cycle. It is independent of epicentral distance, azimuth, travel time, and lapse time, indicating that it is a source characteristic. Damping coefficients for the tornillo's coda range between 0.002 and 0.02. In contrast, damping coefficients for normal long-period events lies between 0.010 and 0.025 and for volcano-tectonic events between 0.010 and 0.040. In March 1996, the Galeras seismic network, which consists of short period, single-component seismometers, was augmented with a broadband, three-component station. This station, installed 1.5 km south of Galeras active cone, recorded a series of six tornillos. Narrowband and broadband tornillo records have similar characteristics in the time and frequency domains.
    Description: JCR Journal
    Description: open
    Keywords: volcanoes ; seismic events ; broadband record ; tornillos ; Galeras volcano ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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