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  • 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology  (3)
  • Cells, Cultured  (3)
  • 2005-2009  (3)
  • 2000-2004  (3)
  • 1
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    Filopodial calcium transients promote substrate-dependent growth cone turning (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-10
    Description: Filopodia that extend from neuronal growth cones sample the environment for extracellular guidance cues, but the signals they transmit to growth cones are unknown. Filopodia were observed generating localized transient elevations of intracellular calcium ([Ca2+]i) that propagate back to the growth cone and stimulate global Ca2+ elevations. The frequency of filopodial Ca2+ transients was substrate-dependent and may be due in part to influx of Ca2+ through channels activated by integrin receptors. These transients slowed neurite outgrowth by reducing filopodial motility and promoted turning when stimulated differentially within filopodia on one side of the growth cone. These rapid signals appear to serve both as autonomous regulators of filopodial movement and as frequency-coded signals integrated within the growth cone and could be a common signaling process for many motile cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gomez, T M -- Robles, E -- Poo , M -- Spitzer, N C -- New York, N.Y. -- Science. 2001 Mar 9;291(5510):1983-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093, USA. tmgomez@facstaff.wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11239161" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD29/metabolism ; Calcium/*metabolism ; *Calcium Signaling ; Cell Movement ; Cells, Cultured ; Culture Techniques ; Embryo, Nonmammalian/cytology ; Growth Cones/metabolism/*physiology ; Integrins/metabolism ; Laminin/pharmacology ; Microscopy, Confocal ; Neurites/metabolism/*physiology ; Neurons/physiology ; Oligopeptides/pharmacology ; Pseudopodia/*metabolism ; Tenascin/pharmacology ; Xenopus/embryology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    G-protein signaling through tubby proteins (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-05-26
    Description: Dysfunction of the tubby protein results in maturity-onset obesity in mice. Tubby has been implicated as a transcription regulator, but details of the molecular mechanism underlying its function remain unclear. Here we show that tubby functions in signal transduction from heterotrimeric GTP-binding protein (G protein)-coupled receptors. Tubby localizes to the plasma membrane by binding phosphatidylinositol 4,5-bisphosphate through its carboxyl terminal "tubby domain." X-ray crystallography reveals the atomic-level basis of this interaction and implicates tubby domains as phosphorylated-phosphatidyl- inositol binding factors. Receptor-mediated activation of G protein alphaq (Galphaq) releases tubby from the plasma membrane through the action of phospholipase C-beta, triggering translocation of tubby to the cell nucleus. The localization of tubby-like protein 3 (TULP3) is similarly regulated. These data suggest that tubby proteins function as membrane-bound transcription regulators that translocate to the nucleus in response to phosphoinositide hydrolysis, providing a direct link between G-protein signaling and the regulation of gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santagata, S -- Boggon, T J -- Baird, C L -- Gomez, C A -- Zhao, J -- Shan, W S -- Myszka, D G -- Shapiro, L -- New York, N.Y. -- Science. 2001 Jun 15;292(5524):2041-50. Epub 2001 May 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ruttenberg Cancer Center, Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, 1425 Madison Avenue New York, NY 10029, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11375483" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Adaptor Proteins, Signal Transducing ; Amino Acid Sequence ; Animals ; Cell Membrane/metabolism ; Cell Nucleus/*metabolism ; Cells, Cultured ; Crystallography, X-Ray ; GTP-Binding Protein alpha Subunits, Gq-G11 ; Gene Expression Regulation ; Heterotrimeric GTP-Binding Proteins/*metabolism ; Humans ; Isoenzymes/*metabolism ; Membrane Lipids/metabolism ; Mice ; Models, Biological ; Molecular Sequence Data ; Nuclear Localization Signals ; Obesity/genetics/metabolism ; Phosphatidylinositol 4,5-Diphosphate/*metabolism ; Phosphatidylinositol Phosphates/metabolism ; Phospholipase C beta ; Phosphorylation ; Protein Structure, Tertiary ; Proteins/chemistry/genetics/*metabolism ; Receptor, Serotonin, 5-HT2C ; Receptors, Muscarinic/metabolism ; Receptors, Serotonin/metabolism ; Recombinant Fusion Proteins/metabolism ; *Signal Transduction ; Transcription Factors/chemistry/genetics/*metabolism ; Type C Phospholipases/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-13
    Description: We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained suppression of viremia, preserving CD4 levels and permitting the induction of virus-specific cellular immunity. L-870812 was also active in chronic infection; however, the magnitude and durability of the effect varied in conjunction with the pretreatment immune response and viral load. These studies demonstrate integrase inhibitor activity in vivo and suggest that cellular immunity facilitates chemotherapeutic efficacy in retroviral infections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hazuda, Daria J -- Young, Steven D -- Guare, James P -- Anthony, Neville J -- Gomez, Robert P -- Wai, John S -- Vacca, Joseph P -- Handt, Larry -- Motzel, Sherri L -- Klein, Hilton J -- Dornadula, Geethanjali -- Danovich, Robert M -- Witmer, Marc V -- Wilson, Keith A A -- Tussey, Lynda -- Schleif, William A -- Gabryelski, Lori S -- Jin, Lixia -- Miller, Michael D -- Casimiro, Danilo R -- Emini, Emilio A -- Shiver, John W -- New York, N.Y. -- Science. 2004 Jul 23;305(5683):528-32. Epub 2004 Jul 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, Merck Research Laboratories, Post Office Box 4, West Point, PA 19486, USA. daria_hazuda@merck.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15247437" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*drug therapy/*immunology/virology ; Animals ; Anti-HIV Agents/administration & dosage/blood/pharmacology/therapeutic use ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Drug Resistance, Viral ; HIV Integrase/genetics/metabolism ; HIV Integrase Inhibitors/administration & dosage/blood/pharmacology/therapeutic ; use ; HIV-1/drug effects/enzymology/genetics/*physiology ; Immunity, Cellular ; Integrase Inhibitors/administration & dosage/blood/pharmacology/*therapeutic use ; Integrases/genetics/metabolism ; Leukocytes, Mononuclear/virology ; Macaca mulatta ; Mutation ; Naphthyridines/administration & dosage/blood/pharmacology/*therapeutic use ; Simian Acquired Immunodeficiency Syndrome/*drug therapy/*immunology/virology ; Simian Immunodeficiency Virus/drug effects/enzymology/genetics/*physiology ; Viral Load ; Viremia/drug therapy ; Virus Replication/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Unusual seismic signals associated with the activity at Galeras volcano, Colombia, from July 1992 to September 1994 (2006)
    Details
    Publication Date: 2019-11-04
    Description: After the emplacement of a lava dome at Galeras volcano in 1991, seven eruptions occurred from July 16, 1992, to September 23, 1994, six of which were preceded by quasi-monochromatic, long-duration seismic events with slowly decaying coda named «tornillos» (screws). The dominant frequencies of these unusual seismic signals are related to source characteristics and show temporal changes, diminishing and then tending to stabilize before an eruption. At the same time, the accumulated number and the duration of these signals increase several days prior to the eruption. The increase in the duration of the tornillo events and the decline of the dominant frequencies both suggest an increasing impedance contrast between the surrounding solid material and the fluid. These characteristics may be associated with an increase in the free gas phase in the magma produced by saturation of volatiles due to cooling, crystallization and partial solidification of the column of magma plugging the conduits. The solidified magma can contribute to sealing the conduits and preventing free gas escape, with consequent generation of overpressure. An eruption is initiated when the overpressure exceeds the resistance strength of the solid material.
    Description: JCR Journal
    Description: open
    Keywords: Galeras ; tornillo events ; seismic signals ; eruptions ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
    Format: 3271532 bytes
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  • 5
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    The anatomy of a tornillo: puzzles from three-component measurements at Galeras volcano (Colombia) (2006)
    Details
    Publication Date: 2019-11-04
    Description: Many of the recent ash eruptions of Galeras volcano (Colombia) have been preceded by tornillos. These unusual seismic events of unknown origin have screw-like profiles on seismograms and can last up to several minutes. In March, 1996, a broadband, three-component seismometer station was installed 1.6 km south of Cono, Galeras' active vent. With high quality recordings acquired by this system, and methods which work well with narrow band signals, we investigate the frequency content and polarization properties of two tornillos. They have slighty different predominant frequencies, 3.0420 Hz and 3.0595 Hz which remain highly stable for the entire tornillo duration. The polarization analysis shows that the polarization for the two events also differs slightly but remains constant. Most of their energy is linearly polarized and lies in the horizontal plane. If these waves are taken to be SH waves, the remaining energy is confined to the beginning of the tornillo during its initiation or excitation. The remainder of the tornillo is characterized by exponential decay. These observations provide parameters for the classification of tornillos and constraints for source models.
    Description: JCR Journal
    Description: open
    Keywords: Galeras ; tornillo ; polarizations ; analytic function ; parametrization ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
    Format: 2807037 bytes
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  • 6
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    Tornillo seismic events at Galeras volcano, Colombia: a summary and new information from broadband three-component measurements (2006)
    Details
    Publication Date: 2019-11-04
    Description: Long-duration events have been recorded at several active, andesitic volcanoes. Their main characteristics are a single, sharp frequency peak, and an exceptionally long coda. Because their seismograms resemble a screw, these signals are called "tornillos" in Colombia. These events have been recorded during different stages of volcanic activity at various volcanoes worldwide. Tornillos have occurred for example, as a short-term precursor to eruptions at Galeras volcano, Colombia (1992-1993); and at Asama volcano, Japan, (1983). At Tokachi volcano, Japan, they were recorded after an eruption (1989). The Tornillo's dominant frequency appears to be related to the time of occurrence during an eruption cycle. It is independent of epicentral distance, azimuth, travel time, and lapse time, indicating that it is a source characteristic. Damping coefficients for the tornillo's coda range between 0.002 and 0.02. In contrast, damping coefficients for normal long-period events lies between 0.010 and 0.025 and for volcano-tectonic events between 0.010 and 0.040. In March 1996, the Galeras seismic network, which consists of short period, single-component seismometers, was augmented with a broadband, three-component station. This station, installed 1.5 km south of Galeras active cone, recorded a series of six tornillos. Narrowband and broadband tornillo records have similar characteristics in the time and frequency domains.
    Description: JCR Journal
    Description: open
    Keywords: volcanoes ; seismic events ; broadband record ; tornillos ; Galeras volcano ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
    Format: 4127971 bytes
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