Publication Date:
2002-07-20
Description:
Mammalian organogenesis requires the expansion of pluripotent precursor cells before the subsequent determination of specific cell types, but the tissue-specific molecular mechanisms that regulate the initial expansion of primordial cells remain poorly defined. We have genetically established that Six6 homeodomain factor, acting as a strong tissue-specific repressor, regulates early progenitor cell proliferation during mammalian retinogenesis and pituitary development. Six6, in association with Dach corepressors, regulates proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. These data reveal a molecular mechanism by which a tissue-specific transcriptional repressor-corepressor complex can provide an organ-specific strategy for physiological expansion of precursor populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Xue -- Perissi, Valentina -- Liu, Forrest -- Rose, David W -- Rosenfeld, Michael G -- 484/B/Telethon/Italy -- 5F32DK09814/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2002 Aug 16;297(5584):1180-3. Epub 2002 Jul 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, Room 345, La Jolla, CA 92093-0648, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12130660" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Apoptosis
;
Cell Cycle
;
Cell Cycle Proteins/genetics/metabolism
;
*Cell Division
;
Cell Line
;
Cyclin-Dependent Kinase Inhibitor p27
;
Cyclin-Dependent Kinases/antagonists & inhibitors
;
Embryo, Mammalian/cytology
;
Eye Proteins/metabolism
;
Homeodomain Proteins/*genetics/*metabolism
;
Mice
;
Nuclear Proteins/metabolism
;
Organ Specificity
;
Pituitary Gland/*cytology/embryology
;
Promoter Regions, Genetic
;
Proto-Oncogene Proteins/genetics/metabolism
;
Recombinant Fusion Proteins/metabolism
;
Repressor Proteins/metabolism
;
Retina/*cytology/embryology
;
Retinal Ganglion Cells/cytology/physiology
;
Stem Cells/*physiology
;
Trans-Activators/*genetics/*metabolism
;
Transcription Factors
;
Transcription, Genetic
;
Transfection
;
Tumor Suppressor Proteins/genetics/metabolism
;
Up-Regulation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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