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  • 1
    Description / Table of Contents: The world's mountain ranges are the clearest manifestations of long-term deformation of the continental crust. As such they have attracted geological investigations for centuries. Throughout this long history of research a few keynote publications stand out. One of the most important is the Geological Survey's 1907 Memoir on The Geological Structure of the North-West Highlands of Scotland. The Memoir summarized some of the Geological Survey's finest work, and outlined many of the principles of field-based structural and tectonic analysis that have subsequently guided generations of geologists working in other mountain belts, both ancient and modern. The thematic set of 32 papers in this Special Publication celebrate the 100th anniversary of the 1907 Memoir by placing the original findings in both historical and modern contexts, and juxtaposing them against present-day studies of deformation processes operating not only in the NW Highlands, but also in other mountain belts.
    Pages: Online-Ressource (VII, 872 Seiten)
    ISBN: 9781862393004
    Language: English
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  • 2
    Publication Date: 2012-04-18
    Description: Hepatitis C virus (HCV) infects ∼2% of the world's population. It is estimated that there are more than 500,000 new infections annually in Egypt, the country with the highest HCV prevalence. An effective vaccine would help control this expanding global health burden. HCV is highly variable, and an effective vaccine should target conserved T- and B-cell epitopes of the virus. Conserved B-cell epitopes overlapping the CD81 receptor-binding site (CD81bs) on the E2 viral envelope glycoprotein have been reported previously and provide promising vaccine targets. In this study, we isolated 73 human mAbs recognizing five distinct antigenic regions on the virus envelope glycoprotein complex E1E2 from an HCV-immune phage-display antibody library by using an exhaustive-panning strategy. Many of these mAbs were broadly neutralizing. In particular, the mAb AR4A, recognizing a discontinuous epitope outside the CD81bs on the E1E2 complex, has an exceptionally broad neutralizing activity toward diverse HCV genotypes and protects against heterologous HCV challenge in a small animal model. The mAb panel will be useful for the design and development of vaccine candidates to elicit broadly neutralizing antibodies to HCV.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 3
    Publication Date: 2011-08-30
    Description: Iron minerals influence the environmental redox behaviour and mobility of metals including the long-lived radionuclide technetium. Technetium is highly mobile in its oxidized form pertechnetate (Tc(VII)[IMG]f1.gif" ALT="Formula" BORDER="0"〉), however, when it is reduced to Tc(IV) it immobilizes readily via precipitation or sorption. In low concentration tracer experiments, and in higher concentration XAS experiments, pertechnetate was added to samples of biogenic and abiotically synthesized Fe(II)-bearing minerals (bio-magnetite, bio-vivianite, bio-siderite and an abiotically precipitated Fe(II) gel). Each mineral scavenged different quantities of Tc(VII) from solution with essentially complete removal in Fe(II)-gel and bio-magnetite systems and with 84{+/-}4% removal onto bio-siderite and 68{+/-}5% removal onto bio-vivianite over 45 days. In select, higher concentration, Tc XAS experiments, XANES spectra showed reductive precipitation to Tc(IV) in all samples. Furthermore, EXAFS spectra for bio-siderite, bio-vivianite and Fe(II)-gel showed that Tc(IV) was present as short range ordered hydrous Tc(IV)O2-like phases in the minerals and for some systems suggested possible incorporation in an octahedral coordination environment. Low concentration reoxidation experiments with air-, and in the case of the Fe(II) gel, nitrate-oxidation of the Tc(IV)-labelled samples resulted in only partial remobilization of Tc. Upon exposure to air, the Tc bound to the Fe-minerals was resistant to oxidative remobilization with a maximum of [~]15% Tc remobilized in the bio-vivianite system after 45 days of air exposure. Nitrate mediated oxidation of Fe(II)-gel inoculated with a stable consortium of nitrate-reducing, Fe(II)-oxidizing bacteria showed only 3.8{+/-}0.4% remobilization of reduced Tc(IV), again highlighting the recalcitrance of Tc(IV) to oxidative remobilization in Fe-bearing systems. The resultant XANES spectra of the reoxidized minerals showed Tc(IV)-like spectra in the reoxidized Fe-phases. Overall, this study highlights the role that Fe-bearing biogenic mineral phases have in controlling reductive scavenging of Tc(VII) to hydrous TcO2-like phases onto a range of Fe(II)-bearing minerals. In addition, it suggests that on reoxidation of these phases, Fe-bound Tc(IV) may be octahedrally coordinated and is largely recalcitrant to reoxidation over medium-term timescales. This has implications when considering remediation approaches and in predictions of the long-term fate of Tc in the nuclear legacy.
    Print ISSN: 0026-461X
    Electronic ISSN: 1471-8022
    Topics: Geosciences
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  • 4
    Publication Date: 2012-07-20
    Description: Although grand-design spiral galaxies are relatively common in the local Universe, only one has been spectroscopically confirmed to lie at redshift z 〉 2 (HDFX 28; z = 2.011); and it may prove to be a major merger that simply resembles a spiral in projection. The rarity of spirals has been explained as a result of disks being dynamically 'hot' at z 〉 2 (refs 2-5), which may instead favour the formation of commonly observed clumpy structures. Alternatively, current instrumentation may simply not be sensitive enough to detect spiral structures comparable to those in the modern Universe. At z 〈 2, the velocity dispersion of disks decreases, and spiral galaxies are more numerous by z approximately 1 (refs 7, 13-15). Here we report observations of the grand-design spiral galaxy Q2343-BX442 at z = 2.18. Spectroscopy of ionized gas shows that the disk is dynamically hot, implying an uncertain origin for the spiral structure. The kinematics of the galaxy are consistent with a thick disk undergoing a minor merger, which can drive the formation of short-lived spiral structure. A duty cycle of 〈100 Myr for such tidally induced spiral structure in a hot massive disk is consistent with its rarity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Law, David R -- Shapley, Alice E -- Steidel, Charles C -- Reddy, Naveen A -- Christensen, Charlotte R -- Erb, Dawn K -- England -- Nature. 2012 Jul 18;487(7407):338-40. doi: 10.1038/nature11256.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dunlap Institute for Astronomy & Astrophysics, University of Toronto, 50 St George Street, Toronto M5S 3H4, Ontario, Canada. drlaw@di.utoronto.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22810697" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2012-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garcia, S M -- Kolding, J -- Rice, J -- Rochet, M-J -- Zhou, S -- Arimoto, T -- Beyer, J E -- Borges, L -- Bundy, A -- Dunn, D -- Fulton, E A -- Hall, M -- Heino, M -- Law, R -- Makino, M -- Rijnsdorp, A D -- Simard, F -- Smith, A D M -- New York, N.Y. -- Science. 2012 Mar 2;335(6072):1045-7. doi: 10.1126/science.1214594.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Commission on Ecosystem Management, International Union for Conservation of Nature (IUCN-CEM), Fisheries Expert Group, Brussels, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22383833" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; Biomass ; Body Size ; *Conservation of Natural Resources ; *Ecosystem ; *Fisheries ; *Fishes ; Models, Biological ; Policy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2013-01-30
    Description: Around the world large quantities of sludge wastes derived from nuclear energy production are currently kept in storage facilities. In the UK, the British government has marked sludge removal as a top priority as these facilities are nearing the end of their operational lifetimes. Therefore chemical understanding of uranium uptake in Mg-rich sludge is critical for successful remediation strategies. Previous studies have explored uranium uptake by the calcium carbonate minerals, calcite and aragonite, under conditions applicable to both natural and anthropogenically perturbed systems. However, studies of the uptake by Mg-rich minerals such as brucite [Mg(OH) 2 ], nesquehonite [MgCO 3 ·3H 2 O] and hydromagnesite [Mg 5 (CO 3 ) 4 (OH) 2 ·4H 2 O], have not been previously conducted. Such experiments will improve our understanding of the mobility of uranium and other actinides in natural lithologies as well as provide key information applicable to nuclear waste repository strategies involving Mg-rich phases. Experiments with mineral powders were used to determine the partition coefficients ( K d ) and coordination of $${\mathrm{UO}}_{2}^{2+}$$ during adsorption and co-precipitation with brucite, nesquehonite and hydromagnesite. The K d values for the selected Mg-rich minerals were comparable or greater than those published for calcium carbonates. Extended X-ray absorption fine structure analysis results showed that the structure of the uranyl-triscarbonato [UO 2 (CO 3 ) 3 ] species was maintained after surface attachment and that uptake of uranyl ions took place mainly via mineral surface reactions.
    Print ISSN: 0026-461X
    Electronic ISSN: 1471-8022
    Topics: Geosciences
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  • 7
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 8
    Publication Date: 2019-07-17
    Description: The Southern Ocean (44–75°S) plays a critical role in the global carbon cycle, yet remains one of the most poorly sampled ocean regions. Different approaches have been used to estimate sea–air CO2 fluxes in this region: synthesis of surface ocean observations, ocean biogeochemical models, and atmospheric and ocean inversions. As part of the RECCAP (REgional Carbon Cycle Assessment and Processes) project, we combine these different approaches to quantify and assess the magnitude and variability in Southern Ocean sea–air CO2 fluxes between 1990–2009. Using all models and inversions (26), the integrated median annual sea–air CO2 flux of −0.42 ± 0.07 PgC yr−1 for the 44–75°S region, is consistent with the −0.27 ± 0.13 PgC yr−1 calculated using surface observations. The circumpolar region south of 58°S has a small net annual flux (model and inversion median: −0.04 ± 0.07 PgC yr−1 and observations: +0.04 ± 0.02 PgC yr−1), with most of the net annual flux located in the 44 to 58°S circumpolar band (model and inversion median: −0.36 ± 0.09 PgC yr−1 and observations: −0.35 ± 0.09 PgC yr−1). Seasonally, in the 44–58°S region, the median of 5 ocean biogeochemical models captures the observed sea–air CO2 flux seasonal cycle, while the median of 11 atmospheric inversions shows little seasonal change in the net flux. South of 58°S, neither atmospheric inversions nor ocean biogeochemical models reproduce the phase and amplitude of the observed seasonal sea–air CO2 flux, particularly in the AustralWinter. Importantly, no individual atmospheric inversion or ocean biogeochemical model is capable of reproducing both the observed annual mean uptake and the observed seasonal cycle. This raises concerns about projecting future changes in Southern Ocean CO2 fluxes. The median interannual variability from atmospheric inversions and ocean biogeochemical models is substantial in the Southern Ocean; up to 25% of the annual mean flux, with 25% of this interannual variability attributed to the region south of 58°S. Resolving long-term trends is difficult due to the large interannual variability and short time frame (1990–2009) of this study; this is particularly evident from the large spread in trends from inversions and ocean biogeochemical models. Nevertheless, in the period 1990–2009 ocean biogeochemical models do show increasing oceanic uptake consistent with the expected increase of −0.05 PgC yr−1 decade−1. In contrast, atmospheric inversions suggest little change in the strength of the CO2 sink broadly consistent with the results of Le Quéré et al. (2007).
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 9
    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Biogeosciences 10 (2013): 7035-7052, doi:10.5194/bg-10-7035-2013.
    Description: The Indian Ocean (44° S–30° N) plays an important role in the global carbon cycle, yet it remains one of the most poorly sampled ocean regions. Several approaches have been used to estimate net sea–air CO2 fluxes in this region: interpolated observations, ocean biogeochemical models, atmospheric and ocean inversions. As part of the RECCAP (REgional Carbon Cycle Assessment and Processes) project, we combine these different approaches to quantify and assess the magnitude and variability in Indian Ocean sea–air CO2 fluxes between 1990 and 2009. Using all of the models and inversions, the median annual mean sea–air CO2 uptake of −0.37 ± 0.06 PgC yr−1 is consistent with the −0.24 ± 0.12 PgC yr−1 calculated from observations. The fluxes from the southern Indian Ocean (18–44° S; −0.43 ± 0.07 PgC yr−1 are similar in magnitude to the annual uptake for the entire Indian Ocean. All models capture the observed pattern of fluxes in the Indian Ocean with the following exceptions: underestimation of upwelling fluxes in the northwestern region (off Oman and Somalia), overestimation in the northeastern region (Bay of Bengal) and underestimation of the CO2 sink in the subtropical convergence zone. These differences were mainly driven by lack of atmospheric CO2 data in atmospheric inversions, and poor simulation of monsoonal currents and freshwater discharge in ocean biogeochemical models. Overall, the models and inversions do capture the phase of the observed seasonality for the entire Indian Ocean but overestimate the magnitude. The predicted sea–air CO2 fluxes by ocean biogeochemical models (OBGMs) respond to seasonal variability with strong phase lags with reference to climatological CO2 flux, whereas the atmospheric inversions predicted an order of magnitude higher seasonal flux than OBGMs. The simulated interannual variability by the OBGMs is weaker than that found by atmospheric inversions. Prediction of such weak interannual variability in CO2 fluxes by atmospheric inversions was mainly caused by a lack of atmospheric data in the Indian Ocean. The OBGM models suggest a small strengthening of the sink over the period 1990–2009 of −0.01 PgC decade−1. This is inconsistent with the observations in the southwestern Indian Ocean that shows the growth rate of oceanic pCO2 was faster than the observed atmospheric CO2 growth, a finding attributed to the trend of the Southern Annular Mode (SAM) during the 1990s.
    Description: V. V. S. S. Sarma acknowledges support and encouragement from S. W. A. Naqvi, Director, CSIR-National Institute of Oceanography. A. Lenton and R. M. Law acknowledge support from the Australian Climate Change Science Program, funded by the Australian Government Department of Industry, Innovation, Climate Change, Science, Research and Tertiary Education, and by the Bureau of Meteorology and by CSIRO. S. C. Doney and I. D. Lima acknowledge support from the National Science Foundation (NSF AGS-1048827). N. Metzl acknowledges support of the EU grant 264879 CARBOCHANGE.
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 10
    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Biogeosciences 19 (2013): 4037-4054, doi:10.5194/bg-10-4037-2013.
    Description: The Southern Ocean (44–75° S) plays a critical role in the global carbon cycle, yet remains one of the most poorly sampled ocean regions. Different approaches have been used to estimate sea–air CO2 fluxes in this region: synthesis of surface ocean observations, ocean biogeochemical models, and atmospheric and ocean inversions. As part of the RECCAP (REgional Carbon Cycle Assessment and Processes) project, we combine these different approaches to quantify and assess the magnitude and variability in Southern Ocean sea–air CO2 fluxes between 1990–2009. Using all models and inversions (26), the integrated median annual sea–air CO2 flux of −0.42 ± 0.07 Pg C yr−1 for the 44–75° S region, is consistent with the −0.27 ± 0.13 Pg C yr−1 calculated using surface observations. The circumpolar region south of 58° S has a small net annual flux (model and inversion median: −0.04 ± 0.07 Pg C yr−1 and observations: +0.04 ± 0.02 Pg C yr−1), with most of the net annual flux located in the 44 to 58° S circumpolar band (model and inversion median: −0.36 ± 0.09 Pg C yr−1 and observations: −0.35 ± 0.09 Pg C yr−1). Seasonally, in the 44–58° S region, the median of 5 ocean biogeochemical models captures the observed sea–air CO2 flux seasonal cycle, while the median of 11 atmospheric inversions shows little seasonal change in the net flux. South of 58° S, neither atmospheric inversions nor ocean biogeochemical models reproduce the phase and amplitude of the observed seasonal sea–air CO2 flux, particularly in the Austral Winter. Importantly, no individual atmospheric inversion or ocean biogeochemical model is capable of reproducing both the observed annual mean uptake and the observed seasonal cycle. This raises concerns about projecting future changes in Southern Ocean CO2 fluxes. The median interannual variability from atmospheric inversions and ocean biogeochemical models is substantial in the Southern Ocean; up to 25% of the annual mean flux, with 25% of this interannual variability attributed to the region south of 58° S. Resolving long-term trends is difficult due to the large interannual variability and short time frame (1990–2009) of this study; this is particularly evident from the large spread in trends from inversions and ocean biogeochemical models. Nevertheless, in the period 1990–2009 ocean biogeochemical models do show increasing oceanic uptake consistent with the expected increase of −0.05 Pg C yr−1 decade−1. In contrast, atmospheric inversions suggest little change in the strength of the CO2 sink broadly consistent with the results of Le Quéré et al. (2007).
    Description: A. Lenton, B. Tilbrook, R. J. Matear and R. M. Law were funded by the Australian Climate Change Science Program and theWealth from Oceans National Research Flagship. S. C. Doney acknowledges support from the National Science Foundation (OPP-0823101), T. Takahashi is supported by grants from United States NOAA (NA08OAR4320754) and National Science Foundation (ANT 06-36879). D. Baker, N. Gruber, M. Hoppema, N. Metzl acknowledge the support of EU FP7 project CARBOCHANGE (264879). S. C. Doney acknowledges support from the National Science Foundation (OPP-0823101). N. S. Lovenduski is grateful for support from NSF (OCE-1155240) and NOAA (NA12OAR4310058). This study is also a contribution to the international IMBER/SOLAS Projects. C. Sweeney acknowledges support from the United States NOAA (NA12OAR4310058) and National Science Foundation (0944761).
    Repository Name: Woods Hole Open Access Server
    Type: Article
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