ALBERT

Description: A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) approximately 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for approximately 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751588/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751588/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rietveld, Cornelius A -- Medland, Sarah E -- Derringer, Jaime -- Yang, Jian -- Esko, Tonu -- Martin, Nicolas W -- Westra, Harm-Jan -- Shakhbazov, Konstantin -- Abdellaoui, Abdel -- Agrawal, Arpana -- Albrecht, Eva -- Alizadeh, Behrooz Z -- Amin, Najaf -- Barnard, John -- Baumeister, Sebastian E -- Benke, Kelly S -- Bielak, Lawrence F -- Boatman, Jeffrey A -- Boyle, Patricia A -- Davies, Gail -- de Leeuw, Christiaan -- Eklund, Niina -- Evans, Daniel S -- Ferhmann, Rudolf -- Fischer, Krista -- Gieger, Christian -- Gjessing, Hakon K -- Hagg, Sara -- Harris, Jennifer R -- Hayward, Caroline -- Holzapfel, Christina -- Ibrahim-Verbaas, Carla A -- Ingelsson, Erik -- Jacobsson, Bo -- Joshi, Peter K -- Jugessur, Astanand -- Kaakinen, Marika -- Kanoni, Stavroula -- Karjalainen, Juha -- Kolcic, Ivana -- Kristiansson, Kati -- Kutalik, Zoltan -- Lahti, Jari -- Lee, Sang H -- Lin, Peng -- Lind, Penelope A -- Liu, Yongmei -- Lohman, Kurt -- Loitfelder, Marisa -- McMahon, George -- Vidal, Pedro Marques -- Meirelles, Osorio -- Milani, Lili -- Myhre, Ronny -- Nuotio, Marja-Liisa -- Oldmeadow, Christopher J -- Petrovic, Katja E -- Peyrot, Wouter J -- Polasek, Ozren -- Quaye, Lydia -- Reinmaa, Eva -- Rice, John P -- Rizzi, Thais S -- Schmidt, Helena -- Schmidt, Reinhold -- Smith, Albert V -- Smith, Jennifer A -- Tanaka, Toshiko -- Terracciano, Antonio -- van der Loos, Matthijs J H M -- Vitart, Veronique -- Volzke, Henry -- Wellmann, Jurgen -- Yu, Lei -- Zhao, Wei -- Allik, Juri -- Attia, John R -- Bandinelli, Stefania -- Bastardot, Francois -- Beauchamp, Jonathan -- Bennett, David A -- Berger, Klaus -- Bierut, Laura J -- Boomsma, Dorret I -- Bultmann, Ute -- Campbell, Harry -- Chabris, Christopher F -- Cherkas, Lynn -- Chung, Mina K -- Cucca, Francesco -- de Andrade, Mariza -- De Jager, Philip L -- De Neve, Jan-Emmanuel -- Deary, Ian J -- Dedoussis, George V -- Deloukas, Panos -- Dimitriou, Maria -- Eiriksdottir, Guethny -- Elderson, Martin F -- Eriksson, Johan G -- Evans, David M -- Faul, Jessica D -- Ferrucci, Luigi -- Garcia, Melissa E -- Gronberg, Henrik -- Guethnason, Vilmundur -- Hall, Per -- Harris, Juliette M -- Harris, Tamara B -- Hastie, Nicholas D -- Heath, Andrew C -- Hernandez, Dena G -- Hoffmann, Wolfgang -- Hofman, Adriaan -- Holle, Rolf -- Holliday, Elizabeth G -- Hottenga, Jouke-Jan -- Iacono, William G -- Illig, Thomas -- Jarvelin, Marjo-Riitta -- Kahonen, Mika -- Kaprio, Jaakko -- Kirkpatrick, Robert M -- Kowgier, Matthew -- Latvala, Antti -- Launer, Lenore J -- Lawlor, Debbie A -- Lehtimaki, Terho -- Li, Jingmei -- Lichtenstein, Paul -- Lichtner, Peter -- Liewald, David C -- Madden, Pamela A -- Magnusson, Patrik K E -- Makinen, Tomi E -- Masala, Marco -- McGue, Matt -- Metspalu, Andres -- Mielck, Andreas -- Miller, Michael B -- Montgomery, Grant W -- Mukherjee, Sutapa -- Nyholt, Dale R -- Oostra, Ben A -- Palmer, Lyle J -- Palotie, Aarno -- Penninx, Brenda W J H -- Perola, Markus -- Peyser, Patricia A -- Preisig, Martin -- Raikkonen, Katri -- Raitakari, Olli T -- Realo, Anu -- Ring, Susan M -- Ripatti, Samuli -- Rivadeneira, Fernando -- Rudan, Igor -- Rustichini, Aldo -- Salomaa, Veikko -- Sarin, Antti-Pekka -- Schlessinger, David -- Scott, Rodney J -- Snieder, Harold -- St Pourcain, Beate -- Starr, John M -- Sul, Jae Hoon -- Surakka, Ida -- Svento, Rauli -- Teumer, Alexander -- LifeLines Cohort Study -- Tiemeier, Henning -- van Rooij, Frank J A -- Van Wagoner, David R -- Vartiainen, Erkki -- Viikari, Jorma -- Vollenweider, Peter -- Vonk, Judith M -- Waeber, Gerard -- Weir, David R -- Wichmann, H-Erich -- Widen, Elisabeth -- Willemsen, Gonneke -- Wilson, James F -- Wright, Alan F -- Conley, Dalton -- Davey-Smith, George -- Franke, Lude -- Groenen, Patrick J F -- Hofman, Albert -- Johannesson, Magnus -- Kardia, Sharon L R -- Krueger, Robert F -- Laibson, David -- Martin, Nicholas G -- Meyer, Michelle N -- Posthuma, Danielle -- Thurik, A Roy -- Timpson, Nicholas J -- Uitterlinden, Andre G -- van Duijn, Cornelia M -- Visscher, Peter M -- Benjamin, Daniel J -- Cesarini, David -- Koellinger, Philipp D -- AA09367/AA/NIAAA NIH HHS/ -- AA11886/AA/NIAAA NIH HHS/ -- BB/F019394/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- CZB/4/710/Chief Scientist Office/United Kingdom -- DA024417/DA/NIDA NIH HHS/ -- DA029377/DA/NIDA NIH HHS/ -- DA05147/DA/NIDA NIH HHS/ -- DA13240/DA/NIDA NIH HHS/ -- ETM/55/Chief Scientist Office/United Kingdom -- F31 DA029377/DA/NIDA NIH HHS/ -- G0600705/Medical Research Council/United Kingdom -- G0700704/Medical Research Council/United Kingdom -- G9815508/Medical Research Council/United Kingdom -- K05 AA017688/AA/NIAAA NIH HHS/ -- MC_PC_U127561128/Medical Research Council/United Kingdom -- MC_UU_12013/1/Medical Research Council/United Kingdom -- MC_UU_12013/3/Medical Research Council/United Kingdom -- MC_UU_12013/5/Medical Research Council/United Kingdom -- MH016880/MH/NIMH NIH HHS/ -- MH066140/MH/NIMH NIH HHS/ -- MR/K026992/1/Medical Research Council/United Kingdom -- P01 AG005842/AG/NIA NIH HHS/ -- P01 CA089392/CA/NCI NIH HHS/ -- P01 GM099568/GM/NIGMS NIH HHS/ -- P01-AG005842/AG/NIA NIH HHS/ -- P01-AG005842-20S2/AG/NIA NIH HHS/ -- P30 AG012810/AG/NIA NIH HHS/ -- P30-AG012810/AG/NIA NIH HHS/ -- R01 AA009367/AA/NIAAA NIH HHS/ -- R01 AA011886/AA/NIAAA NIH HHS/ -- R01 DA013240/DA/NIDA NIH HHS/ -- R01 HL090620/HL/NHLBI NIH HHS/ -- R01 HL105756/HL/NHLBI NIH HHS/ -- R01 HL111314/HL/NHLBI NIH HHS/ -- R01 MH066140/MH/NIMH NIH HHS/ -- R37 DA005147/DA/NIDA NIH HHS/ -- T32 AG000186/AG/NIA NIH HHS/ -- T32 MH016880/MH/NIMH NIH HHS/ -- T32-AG000186-23/AG/NIA NIH HHS/ -- U01 AG009740/AG/NIA NIH HHS/ -- U01 DA024417/DA/NIDA NIH HHS/ -- Z01 AG001050-01/Intramural NIH HHS/ -- ZIA AG000196-03/Intramural NIH HHS/ -- ZIA AG000196-04/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2013 Jun 21;340(6139):1467-71. doi: 10.1126/science.1235488. Epub 2013 May 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23722424" target="_blank"〉PubMed〈/a〉

Description: The 11–13 January 2011 eruptive episode at Etna volcano occurred after several months of increasing ash emissions from the summit craters, and was heralded by increasing SO2 output, which peaked at ∼5000 megagrams/day several hours before the start of the eruptive activity. The eruptive episode began with a phase of Strombolian activity from a pit crater on the eastern flank of the SE‐Crater. Explosions became more intense with time and eventually became transitional between Strombolian and fountaining, before moving into a lava fountaining phase. Fountaining was accompanied by lava output from the lower rim of the pit crater. Emplacement of the resulting lava flow field, as well as associated lava fountain‐ and Strombolian‐phases, was tracked using a remote sensing network comprising both thermal and visible cameras. Thermal surveys completed once the eruptive episode had ended also allowed us to reconstruct the emplacement of the lava flow field. Using a high temporal resolution geostationary satellite data we were also able to construct a detailed record of the heat flux during the fountain‐fed flow phase and its subsequent cooling. The dense rock volume of erupted lava obtained from the satellite data was 1.2 × 106 m3; this was emplaced over a period of about 6 h to give a mean output rate of ∼55 m3 s−1. By comparison, geologic data allowed us to estimate dense rock volumes of ∼0.85 × 106 m3 for the pyroclastics erupted during the lava fountain phase, and 0.84–1.7 × 106 m3 for lavas erupted during the effusive phase, resulting in a total erupted dense rock volume of 1.7–2.5 × 106 m3 and a mean output rate of 78–117 m3 s−1. The sequence of events and quantitative results presented here shed light on the shallow feeding system of the volcano.

Description: Published

Description: B11207

Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani

Description: JCR Journal

Description: partially_open

Description: We present a new method that uses cooling curves, apparent in high temporal resolution thermal data acquired by geostationary sensors, to estimate erupted volumes and mean output rates during short lava fountaining events. The 15 minute temporal resolution of the data allows phases of waxing and peak activity to be identified during short (150-to- 810 minute-long) events. Cooling curves, which decay over 8-to-21 hour-periods following the fountaining event, can also be identified. Application to 19 fountaining events recorded at Etna by MSG’s SEVIRI sensor between 10 January 2011 and 9 January 2012, yields a total erupted dense rock lava volume of 28 106 m3, with a maximum intensity of 227 m3 s 1 being obtained for the 12 August 2011 event. The timeaveraged output over the year was 0.9 m3 s 1, this being the same as the rate that has characterized Etna’s effusive activity for the last 40 years.

Description: We are grateful to EUMETSAT for SEVIRI data.

Description: Published

Description: L06305

Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani

Description: JCR Journal

Description: restricted

Description: In the paper by Gouhier, M., Harris, A., Calvari, S., Labazuy, P., Guéhenneux, Y., Donnadieu, F., Valade, S, entitled “Lava discharge during Etna’s January 2011 fire fountain tracked using MSG-SEVIRI” (Bull Volcanol (2012) 74:787–793, DOI 10.1007/s00445-011-0572-y), we present data from a Doppler radar (VOLDORAD 2B). This ground-based Lband radar has been monitoring the eruptive activity of the summit craters of Mt. Etna in real-time since July 2009 from a site about 3.5 km SSE of the craters. Examples of applications of this type of radar are reviewed by Donnadieu (2012) and shown on the VOLDORAD website (http://wwwobs. univbpclermont.fr/SO/televolc/voldorad/). Although designed and owned by the Observatoire de Physique du Globe in Clermont-Ferrand (OPGC), France, VOLDORAD 2B is operated jointly with the INGV-Catania (Italy) in the framework of a technical and scientific collaboration agreement between the INGV of Catania, the French CNRS and the OPGC-Université Blaise Pascal in Clermont- Ferrand. The system also utilizes a dedicated micropatch antenna designed at the University of Calabria (Boccia et al. 2010) and owned by INGV. The objective of the joint acquisition of the radar data by INGV-Catania and the OPGC is twofold: (1) to mitigate volcanic risks at Etna by better assessing the hazards arising from ash plumes and (2) to allow detailed study of volcanic activity and its environmental impact. In the paper by Gouhier et al. (2012), we failed to highlight this important collaboration between the INGV Catania and the OPGC; a cooperation essential for the past, current and future generation of such valuable data sets. Specifically we wish to acknowledge the roles of Mauro Coltelli, Michele Prestifilippo and Simona Scollo for their important input into this project, and pivotal role in setting up, and maintaining, this collaborative deployment.

Description: Published

Description: 1261

Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani

Description: JCR Journal

Description: restricted

Description: Etna's January 2011 eruption provided an excellent opportunity to test the ability of Meteosat Second Generation satellite's Spinning Enhanced Visible and InfraRed Imager (SEVIRI) sensor to track a short-lived effusive event. The presence of lava fountaining, the rapid expansion of lava flows, and the complexity of the resulting flow field make such events difficult to track from the ground. During the Etna's January 2011 eruption, we were able to use thermal data collected by SEVIRI every 15 min to generate a time series of the syn-eruptive heat flux. Lava discharge waxed over a ~1-h period to reach a peak that was first masked from the satellite view by a cold tephra plume and then was of sufficient intensity to saturate the 3.9-μm channel. Both problems made it impossible to estimate time-averaged lava discharge rates using the syn-eruptive heat flux curve. Therefore, through integration of data obtained by ground-based Doppler radar and thermal cameras, as well as ancillary satellite data (from Moderate Resolution Imaging Spectrometer and Advanced Very High Resolution Radiometer), we developed a method that allowed us to identify the point at which effusion stagnated, to allow definition of a lava cooling curve. This allowed retrieval of a lava volume of ~1.2×106 m3, which, if emitted for 5 h, was erupted at a mean output rate of ~70 m3 s−1. The lava volume estimated using the cooling curve method is found to be similar to the values inferred from field measurements.

Description: This work was supported by the Centre National d’Etudes Spatiales (CNES-France) and CNRS-INSU.

Description: Published

Description: 787–793

Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani

Description: JCR Journal

Description: restricted

Description: Application of light detection and ranging (LIDAR) technology in volcanology has 7 developed rapidly over the past few years, being extremely useful for the generation 8 of high‐spatial‐resolution digital elevation models and for mapping eruption products. 9 However, LIDAR can also be used to yield detailed information about the dynamics of 10 lava movement, emplacement processes occuring across an active lava flow field, and the 11 volumes involved. Here we present the results of a multitemporal airborne LIDAR survey 12 flown to acquire data for an active flow field separated by time intervals ranging from 13 15 min to 25 h. Overflights were carried out over 2 d during the 2006 eruption of Mt. Etna, 14 Italy, coincident with lava emission from three ephemeral vent zones to feed lava flow in 15 six channels. In total 53 LIDAR images were collected, allowing us to track the volumetric 16 evolution of the entire flow field with temporal resolutions as low as ∼15 min and at a 17 spatial resolution of 〈1 m. This, together with accurate correction for systematic errors, 18 finely tuned DEM‐to‐DEM coregistration and an accurate residual error assessment, 19 permitted the quantification of the volumetric changes occuring across the flow field. We 20 record a characteristic flow emplacement mode, whereby flow front advance and channel 21 construction is fed by a series of volume pulses from the master vent. Volume pulses 22 have a characteristic morphology represented by a wave that moves down the channel 23 modifying existing channel‐levee constructs across the proximal‐medial zone and building 24 new ones in the distal zone. Our high‐resolution multitemporal LIDAR‐derived DEMs 25 allow calculation of the time‐averaged discharge rates associated with such a pulsed flow 26 emplacement regime, with errors under 1% for daily averaged values.

Description: This work was partially funded by the Italian 930 Dipartimento della Protezione Civile in the frame of the 2007–2009 Agree- 931 ment with Istituto Nazionale di Geofisica e Vulcanologia–INGV. A.F. 932 benefited from the MIUR‐FIRB project “Piattaforma di ricerca multi‐disci- 933 plinare su terremoti e vulcani (AIRPLANE)” n. RBPR05B2ZJ. S.T. 934 benefited from the project FIRB “Sviluppo di nuove tecnologie per la prote- 935 zione e difesa del territorio dai rischi naturali (FUMO)” funded by the Italian 936 Ministero dell’Istruzione, dell’Università e della Ricerca.

Description: Published

Description: B11203

Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani

Description: 1.10. TTC - Telerilevamento

Description: 3.6. Fisica del vulcanismo

Description: JCR Journal

Description: reserved

Description: In the paper “Thirty years of satellite-derived lava discharge rates at Etna: Implications for steady volumetric output” by Andrew Harris et al. (Journal of Geophysical Research, 116, B08204, doi:10.1029/2011JB008237), the numbers on Table A1 were wrong. The correct values for Table A1 are reported here.

Description: Published

Description: B08207

Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani

Description: JCR Journal

Description: restricted

Description: Using Etna as a case study location, we examine the balance between the volume of magma supplied to the shallow volcanic system (using ground-based SO2 data) and the volume erupted (using satellite thermal data). We do this for three eruptions of Mt. Etna (Italy) during 2002 to 2006. We find that, during the three eruptions, 2.3×107 m3 or 24% of the degassed volume remained unerupted. However, variations in the degree of partitioning between supplied (Vsupply) and erupted (Verupt) magma occur within individual eruptions over the time scales of days. Consequently, we define and quantify three types of partitioning. In the first case, VsupplybVerupt, i.e. more lava is erupted than is supplied. In such a case previously degassed magma is erupted or magma can rise faster than it is able to degas, as occurred during the open phases of the 2002–2003 and 2004–2005 eruptions, respectively. In the second case, VsupplyNVerupt, i.e. less lava is erupted than is supplied. In such a case, magma can erupt in an explosive manner, as occurred during Phase II of the 2002–2003 eruption, or remain within or below the edifice. In the third case, Vsupply=Verupt, i.e. all supplied magma is erupted. During 2002–2006, over a total of 280 days of eruptive activity, this balancing case applied to 50% of the time.

Description: Published

Description: 47-53

Description: JCR Journal

Description: reserved

Description: Between 1994 and 2010, we completed 16 thermal surveys of Vulcano’s Fossa fumarole field (Aeolian Islands, Italy). In each survey, between 400 and 1,200 vent temperatures were collected using a thermal infrared thermometer from distances of ∼1 m. The results show a general decrease in average vent temperature during 1994–2003, with the average for the entire field falling from ∼220°C in 1994 to ∼150°C by 2003. However, between 2004 and 2010, we witnessed heating, with the average increasing to ∼190°C by 2010. Alongside these annual-scale field-wide trends, we record a spatial re-organisation of the fumarole field, characterised by shut down of vent zones towards the crater floor, matched by rejuvenation of zones located towards the crater rim. Heating may be expected to be associated with deflation because increased amounts of vaporisation will remove volume from the hydrothermal system Gambino and Guglielmino (J Geophys Res 113: B07402, 2008). However, over the 2004–2010 heating period, no ground deformation was observed. Instead, the number of seismic events increased from a typical rate of 37 events per month during 1994–2000 to 195 events per month during 2004–2010. As part of this increase, we noticed a much greater number of high-frequency events associated with rock fracturing. We thus suggest that the heating event of 2004–2010 was the result of changed permeability conditions, rather than change in the heat supply from the deeper magmatic source. Within this scenario, cooling causes shut down of lower sectors and re-establishment of pathways located towards the crater rim, causing fracturing, increased seismicity and heat flow in these regions. This is consistent with the zone of rejuvenation (which lies towards and at the rim) being the most favourable location for fracturing given the stress field of the Fossa cone Schöpa et al. (J Volcanol Geotherm Res 203:133–145, 2011); it is also the most established zone, having been active at least since the early twentieth century. Our data show the value of deploying multi-disciplinary geophysical campaigns at degassing (fumarolic) hydrothermal systems. This allows more complete and constrained understanding of the true heat loss dynamics of the system. In the case study presented here, it allows us to distinguish true heating from apparent heating phases. While the former are triggered from the bottom-up, i.e. they are driven by increases in heat supply from the magmatic source, the latter are triggered from the top-down, i.e. by changing permeability conditions in the uppermost portion of the system to allow more efficient heat flow over zones predisposed to fracturing.

Description: Published

Description: 1293-1311

Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive

Description: 1.3. TTC - Sorveglianza geodetica delle aree vulcaniche attive

Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive

Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani

Description: 3.6. Fisica del vulcanismo

Description: JCR Journal

Description: restricted

Description: Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in 〉100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P 〈 5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039276/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039276/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teslovich, Tanya M -- Musunuru, Kiran -- Smith, Albert V -- Edmondson, Andrew C -- Stylianou, Ioannis M -- Koseki, Masahiro -- Pirruccello, James P -- Ripatti, Samuli -- Chasman, Daniel I -- Willer, Cristen J -- Johansen, Christopher T -- Fouchier, Sigrid W -- Isaacs, Aaron -- Peloso, Gina M -- Barbalic, Maja -- Ricketts, Sally L -- Bis, Joshua C -- Aulchenko, Yurii S -- Thorleifsson, Gudmar -- Feitosa, Mary F -- Chambers, John -- Orho-Melander, Marju -- Melander, Olle -- Johnson, Toby -- Li, Xiaohui -- Guo, Xiuqing -- Li, Mingyao -- Shin Cho, Yoon -- Jin Go, Min -- Jin Kim, Young -- Lee, Jong-Young -- Park, Taesung -- Kim, Kyunga -- Sim, Xueling -- Twee-Hee Ong, Rick -- Croteau-Chonka, Damien C -- Lange, Leslie A -- Smith, Joshua D -- Song, Kijoung -- Hua Zhao, Jing -- Yuan, Xin -- Luan, Jian'an -- Lamina, Claudia -- Ziegler, Andreas -- Zhang, Weihua -- Zee, Robert Y L -- Wright, Alan F -- Witteman, Jacqueline C M -- Wilson, James F -- Willemsen, Gonneke -- Wichmann, H-Erich -- Whitfield, John B -- Waterworth, Dawn M -- Wareham, Nicholas J -- Waeber, Gerard -- Vollenweider, Peter -- Voight, Benjamin F -- Vitart, Veronique -- Uitterlinden, Andre G -- Uda, Manuela -- Tuomilehto, Jaakko -- Thompson, John R -- Tanaka, Toshiko -- Surakka, Ida -- Stringham, Heather M -- Spector, Tim D -- Soranzo, Nicole -- Smit, Johannes H -- Sinisalo, Juha -- Silander, Kaisa -- Sijbrands, Eric J G -- Scuteri, Angelo -- Scott, James -- Schlessinger, David -- Sanna, Serena -- Salomaa, Veikko -- Saharinen, Juha -- Sabatti, Chiara -- Ruokonen, Aimo -- Rudan, Igor -- Rose, Lynda M -- Roberts, Robert -- Rieder, Mark -- Psaty, Bruce M -- Pramstaller, Peter P -- Pichler, Irene -- Perola, Markus -- Penninx, Brenda W J H -- Pedersen, Nancy L -- Pattaro, Cristian -- Parker, Alex N -- Pare, Guillaume -- Oostra, Ben A -- O'Donnell, Christopher J -- Nieminen, Markku S -- Nickerson, Deborah A -- Montgomery, Grant W -- Meitinger, Thomas -- McPherson, Ruth -- McCarthy, Mark I -- McArdle, Wendy -- Masson, David -- Martin, Nicholas G -- Marroni, Fabio -- Mangino, Massimo -- Magnusson, Patrik K E -- Lucas, Gavin -- Luben, Robert -- Loos, Ruth J F -- Lokki, Marja-Liisa -- Lettre, Guillaume -- Langenberg, Claudia -- Launer, Lenore J -- Lakatta, Edward G -- Laaksonen, Reijo -- Kyvik, Kirsten O -- Kronenberg, Florian -- Konig, Inke R -- Khaw, Kay-Tee -- Kaprio, Jaakko -- Kaplan, Lee M -- Johansson, Asa -- Jarvelin, Marjo-Riitta -- Janssens, A Cecile J W -- Ingelsson, Erik -- Igl, Wilmar -- Kees Hovingh, G -- Hottenga, Jouke-Jan -- Hofman, Albert -- Hicks, Andrew A -- Hengstenberg, Christian -- Heid, Iris M -- Hayward, Caroline -- Havulinna, Aki S -- Hastie, Nicholas D -- Harris, Tamara B -- Haritunians, Talin -- Hall, Alistair S -- Gyllensten, Ulf -- Guiducci, Candace -- Groop, Leif C -- Gonzalez, Elena -- Gieger, Christian -- Freimer, Nelson B -- Ferrucci, Luigi -- Erdmann, Jeanette -- Elliott, Paul -- Ejebe, Kenechi G -- Doring, Angela -- Dominiczak, Anna F -- Demissie, Serkalem -- Deloukas, Panagiotis -- de Geus, Eco J C -- de Faire, Ulf -- Crawford, Gabriel -- Collins, Francis S -- Chen, Yii-der I -- Caulfield, Mark J -- Campbell, Harry -- Burtt, Noel P -- Bonnycastle, Lori L -- Boomsma, Dorret I -- Boekholdt, S Matthijs -- Bergman, Richard N -- Barroso, Ines -- Bandinelli, Stefania -- Ballantyne, Christie M -- Assimes, Themistocles L -- Quertermous, Thomas -- Altshuler, David -- Seielstad, Mark -- Wong, Tien Y -- Tai, E-Shyong -- Feranil, Alan B -- Kuzawa, Christopher W -- Adair, Linda S -- Taylor, Herman A Jr -- Borecki, Ingrid B -- Gabriel, Stacey B -- Wilson, James G -- Holm, Hilma -- Thorsteinsdottir, Unnur -- Gudnason, Vilmundur -- Krauss, Ronald M -- Mohlke, Karen L -- Ordovas, Jose M -- Munroe, Patricia B -- Kooner, Jaspal S -- Tall, Alan R -- Hegele, Robert A -- Kastelein, John J P -- Schadt, Eric E -- Rotter, Jerome I -- Boerwinkle, Eric -- Strachan, David P -- Mooser, Vincent -- Stefansson, Kari -- Reilly, Muredach P -- Samani, Nilesh J -- Schunkert, Heribert -- Cupples, L Adrienne -- Sandhu, Manjinder S -- Ridker, Paul M -- Rader, Daniel J -- van Duijn, Cornelia M -- Peltonen, Leena -- Abecasis, Goncalo R -- Boehnke, Michael -- Kathiresan, Sekar -- 068545/Z/02/Wellcome Trust/United Kingdom -- 076113/B/04/Z/Wellcome Trust/United Kingdom -- 077016/Z/05/Z/Wellcome Trust/United Kingdom -- 079895/Wellcome Trust/United Kingdom -- 1Z01 HG000024/HG/NHGRI NIH HHS/ -- 5R01DK06833603/DK/NIDDK NIH HHS/ -- 5R01DK07568102/DK/NIDDK NIH HHS/ -- 5R01HL087679-02/HL/NHLBI NIH HHS/ -- 5R01HL08770003/HL/NHLBI NIH HHS/ -- 5R01HL08821502/HL/NHLBI NIH HHS/ -- CA 047988/CA/NCI NIH HHS/ -- CZB/4/710/Chief Scientist Office/United Kingdom -- DK062370/DK/NIDDK NIH HHS/ -- DK063491/DK/NIDDK NIH HHS/ -- DK072193/DK/NIDDK NIH HHS/ -- DK078150/DK/NIDDK NIH HHS/ -- DK56350/DK/NIDDK NIH HHS/ -- ES10126/ES/NIEHS NIH HHS/ -- G0000934/Medical Research Council/United Kingdom -- G0401527/Medical Research Council/United Kingdom -- G0601966/Medical Research Council/United Kingdom -- G0700931/Medical Research Council/United Kingdom -- G0701863/Medical Research Council/United Kingdom -- G0801056/Medical Research Council/United Kingdom -- G0801566/Medical Research Council/United Kingdom -- G9521010/Medical Research Council/United Kingdom -- G9521010D/Medical Research Council/United Kingdom -- HHSN268200625226C/PHS HHS/ -- HL 04381/HL/NHLBI NIH HHS/ -- HL 080467/HL/NHLBI NIH HHS/ -- HL-54776/HL/NHLBI NIH HHS/ -- HL085144/HL/NHLBI NIH HHS/ -- K99 HL098364/HL/NHLBI NIH HHS/ -- K99 HL098364-01/HL/NHLBI NIH HHS/ -- K99HL094535/HL/NHLBI NIH HHS/ -- M01-RR00425/RR/NCRR NIH HHS/ -- MC_QA137934/Medical Research Council/United Kingdom -- MC_U106179471/Medical Research Council/United Kingdom -- MC_U106188470/Medical Research Council/United Kingdom -- MC_U127561128/Medical Research Council/United Kingdom -- N01 HC-15103/HC/NHLBI NIH HHS/ -- N01 HC-55222/HC/NHLBI NIH HHS/ -- N01-AG-12100/AG/NIA NIH HHS/ -- N01-HC-25195/HC/NHLBI NIH HHS/ -- N01-HC-35129/HC/NHLBI NIH HHS/ -- N01-HC-45133/HC/NHLBI NIH HHS/ -- N01-HC-55015/HC/NHLBI NIH HHS/ -- N01-HC-55016/HC/NHLBI NIH HHS/ -- N01-HC-55018/HC/NHLBI NIH HHS/ -- N01-HC-55019/HC/NHLBI NIH HHS/ -- N01-HC-55020/HC/NHLBI NIH HHS/ -- N01-HC-55021/HC/NHLBI NIH HHS/ -- N01-HC-55022/HC/NHLBI NIH HHS/ -- N01-HC-75150/HC/NHLBI NIH HHS/ -- N01-HC-85079/HC/NHLBI NIH HHS/ -- N01-HC-85080/HC/NHLBI NIH HHS/ -- N01-HC-85081/HC/NHLBI NIH HHS/ -- N01-HC-85082/HC/NHLBI NIH HHS/ -- N01-HC-85083/HC/NHLBI NIH HHS/ -- N01-HC-85084/HC/NHLBI NIH HHS/ -- N01-HC-85085/HC/NHLBI NIH HHS/ -- N01-HC-85086/HC/NHLBI NIH HHS/ -- N01-HG-65403/HG/NHGRI NIH HHS/ -- N02-HL-6-4278/HL/NHLBI NIH HHS/ -- PG/02/128/British Heart Foundation/United Kingdom -- PG/08/094/British Heart Foundation/United Kingdom -- PG/08/094/26019/British Heart Foundation/United Kingdom -- R01 DK072193/DK/NIDDK NIH HHS/ -- R01 DK078150/DK/NIDDK NIH HHS/ -- R01 HL087647/HL/NHLBI NIH HHS/ -- R01 HL087676/HL/NHLBI NIH HHS/ -- R01 HL089650/HL/NHLBI NIH HHS/ -- R01HL086694/HL/NHLBI NIH HHS/ -- R01HL087641/HL/NHLBI NIH HHS/ -- R01HL087652/HL/NHLBI NIH HHS/ -- R01HL59367/HL/NHLBI NIH HHS/ -- R24 HD050924/HD/NICHD NIH HHS/ -- RC1 HL099634/HL/NHLBI NIH HHS/ -- RC1 HL099634-02/HL/NHLBI NIH HHS/ -- RC1 HL099793/HL/NHLBI NIH HHS/ -- RC2 HL101864,/HL/NHLBI NIH HHS/ -- RC2 HL102419/HL/NHLBI NIH HHS/ -- RG/07/005/23633/British Heart Foundation/United Kingdom -- RR20649/RR/NCRR NIH HHS/ -- SP/08/005/25115/British Heart Foundation/United Kingdom -- T32 GM007092/GM/NIGMS NIH HHS/ -- T32 HG00040/HG/NHGRI NIH HHS/ -- T32HL007208/HL/NHLBI NIH HHS/ -- TW05596/TW/FIC NIH HHS/ -- U01 DK062370/DK/NIDDK NIH HHS/ -- U01 DK062418/DK/NIDDK NIH HHS/ -- U01 HL069757/HL/NHLBI NIH HHS/ -- U01 HL080295/HL/NHLBI NIH HHS/ -- U01HG004402/HG/NHGRI NIH HHS/ -- U54 RR020278/RR/NCRR NIH HHS/ -- UL1RR025005/RR/NCRR NIH HHS/ -- Intramural NIH HHS/ -- England -- Nature. 2010 Aug 5;466(7307):707-13. doi: 10.1038/nature09270.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20686565" target="_blank"〉PubMed〈/a〉