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  • Articles  (2)
  • American Association for the Advancement of Science (AAAS)  (1)
  • The Royal Society  (1)
  • Göttingen : Copernicus Publ.
  • 2010-2014  (2)
  • 1925-1929
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  • 2010-2014  (2)
  • 1925-1929
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  • 1
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    Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and cancer. Here, we report a molecular link between Wnt/beta-catenin signaling and the expression of the telomerase subunit Tert. beta-Catenin-deficient mouse embryonic stem (ES) cells have short telomeres; conversely, ES cell expressing an activated form of beta-catenin (beta-cat(DeltaEx3/+)) have long telomeres. We show that beta-catenin regulates Tert expression through the interaction with Klf4, a core component of the pluripotency transcriptional network. beta-Catenin binds to the Tert promoter in a mouse intestinal tumor model and in human carcinoma cells. We uncover a previously unknown link between the stem cell and oncogenic potential whereby beta-catenin regulates Tert expression, and thereby telomere length, which could be critical in human regenerative therapy and cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoffmeyer, Katrin -- Raggioli, Angelo -- Rudloff, Stefan -- Anton, Roman -- Hierholzer, Andreas -- Del Valle, Ignacio -- Hein, Kerstin -- Vogt, Riana -- Kemler, Rolf -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1549-54. doi: 10.1126/science.1218370.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723415" target="_blank"〉PubMed〈/a〉
    Keywords: Adult Stem Cells/*metabolism ; Animals ; Cell Line, Tumor ; Embryonic Stem Cells/*metabolism ; HEK293 Cells ; Humans ; Kruppel-Like Transcription Factors/metabolism ; Mice ; Neoplasms/genetics/*metabolism ; Promoter Regions, Genetic ; RNA, Messenger/genetics/metabolism ; Telomerase/*genetics/metabolism ; Telomere/metabolism/ultrastructure ; Telomere Homeostasis ; Transcription Initiation Site ; Wnt Proteins/metabolism ; *Wnt Signaling Pathway ; beta Catenin/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Transcriptome sequencing of black grouse ( Tetrao tetrix ) for immune gene discovery and microsatellite development (2012)
    The Royal Society
    Details
    Publication Date: 2012-04-01
    Description: The black grouse ( Tetrao tetrix ) is a galliform bird species that is important for both ecological studies and conservation genetics. Here, we report the sequencing of the spleen transcriptome of black grouse using 454 GS FLX Titanium sequencing. We performed a large-scale gene discovery analysis with a focus on genes that might be related to fitness in this species and also identified a large set of microsatellites. In total, we obtained 182 179 quality-filtered sequencing reads that we assembled into 9035 contigs. Using these contigs and 15 794 length-filtered (greater than 200 bp) singletons, we identified 7762 transcripts that appear to be homologues of chicken genes. A specific BLAST search with an emphasis on immune genes found 308 homologous chicken genes that have immune function, including ten major histocompatibility complex-related genes located on chicken chromosome 16. We also identified 1300 expressed sequence tag microsatellites and were able to design suitable flanking primers for 526 of these. A preliminary test of the polymorphism of the microsatellites found 10 polymorphic microsatellites of the 102 tested. Genomic resources generated in this study should greatly benefit future ecological, evolutionary and conservation genetic studies on this species.
    Electronic ISSN: 2046-2441
    Topics: Biology
    Published by The Royal Society
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