Publication Date:
2013-06-01
Description:
Vaccines are among the greatest successes in the history of public health. However, past strategies for vaccine development are unlikely to succeed in the future against major global diseases such as AIDS, tuberculosis, and malaria. For such diseases, the correlates of protection are poorly defined and the pathogens evade immune detection and/or exhibit extensive genetic variability. Recent advances have heralded in a new era of vaccine discovery. However, translation of these advances into vaccines remains impeded by lack of understanding of key vaccinology principles in humans. We review these advances toward vaccine discovery and suggest that for accelerating successful vaccine development, new human immunology-based clinical research initiatives be implemented with the goal of elucidating and more effectively generating vaccine-induced protective immune responses.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026248/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026248/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koff, Wayne C -- Burton, Dennis R -- Johnson, Philip R -- Walker, Bruce D -- King, Charles R -- Nabel, Gary J -- Ahmed, Rafi -- Bhan, Maharaj K -- Plotkin, Stanley A -- UM1 AI100663/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 May 31;340(6136):1232910. doi: 10.1126/science.1232910.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉International AIDS Vaccine Initiative (IAVI), New York, NY 10004, USA. wkoff@iavi.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23723240" target="_blank"〉PubMed〈/a〉
Keywords:
Acquired Immunodeficiency Syndrome/prevention & control
;
Adjuvants, Immunologic/administration & dosage
;
Animals
;
Antigens/genetics/immunology/isolation & purification
;
*Communicable Disease Control
;
Disease Models, Animal
;
Drug Delivery Systems
;
Humans
;
Malaria/prevention & control
;
Tuberculosis/prevention & control
;
Vaccines/administration & dosage/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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