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  • SPACE RADIATION  (35)
  • Astronomy  (15)
  • Condensed Matter: Electronic Properties, etc.  (4)
  • Mice  (3)
  • Nitric Oxide Synthase
  • 2010-2014  (19)
  • 1990-1994  (38)
  • 1
    Publication Date: 2011-01-21
    Description: Author(s): Randy S. Fishman The magnetic phase diagram of a geometrically frustrated triangular-lattice antiferromagnet is evaluated as a function of magnetic field and anisotropy using a trial spin state built from harmonics of a fundamental ordering wave vector. A noncollinear incommensurate state, observed to be chiral and ... [Phys. Rev. Lett. 106, 037206] Published Thu Jan 20, 2011
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 2
    Publication Date: 1994-09-23
    Description: The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments. In mutant mice deficient in neuronal NO synthase (NOS) activity, infarct volumes decreased significantly 24 and 72 hours after middle cerebral artery occlusion, and the neurological deficits were less than those in normal mice. This result could not be accounted for by differences in blood flow or vascular anatomy. However, infarct size in the mutant became larger after endothelial NOS inhibition by nitro-L-arginine administration. Hence, neuronal NO production appears to exacerbate acute ischemic injury, whereas vascular NO protects after middle cerebral artery occlusion. The data emphasize the importance of developing selective inhibitors of the neuronal isoform.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, Z -- Huang, P L -- Panahian, N -- Dalkara, T -- Fishman, M C -- Moskowitz, M A -- NS10828/NS/NINDS NIH HHS/ -- NS2636/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1994 Sep 23;265(5180):1883-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stroke Research Laboratory, Massachusetts General Hospital, Charlestown 02129.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7522345" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Oxidoreductases/antagonists & inhibitors/deficiency/*metabolism ; Animals ; Arginine/analogs & derivatives/pharmacology ; Brain/enzymology/*metabolism ; Brain Ischemia/complications/*metabolism ; Cerebral Infarction/*etiology ; Cerebrovascular Circulation ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Neurons/*enzymology ; Nitric Oxide/*metabolism ; Nitric Oxide Synthase ; Nitroarginine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1994-07-22
    Description: Long-term potentiation (LTP) is a persistent increase in synaptic strength implicated in certain forms of learning and memory. In the CA1 region of the hippocampus, LTP is thought to involve the release of one or more retrograde messengers from the postsynaptic cell that act on the presynaptic terminal to enhance transmitter release. One candidate retrograde messenger is the membrane-permeant gas nitric oxide (NO), which in the brain is released after activation of the neuronal-specific NO synthase isoform (nNOS). To assess the importance of NO in hippocampal synaptic plasticity, LTP was examined in mice where the gene encoding nNOS was disrupted by gene targeting. In nNOS- mice, LTP induced by weak intensity tetanic stimulation was normal except for a slight reduction in comparison to that in wild-type mice and was blocked by NOS inhibitors, just as it was in wild-type mice. Immunocytochemical studies indicate that in the nNOS- mice as in wild-type mice, the endothelial form of NOS (eNOS) is expressed in CA1 neurons. These findings suggest that eNOS, rather than nNOS, generates NO within the postsynaptic cell during LTP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Dell, T J -- Huang, P L -- Dawson, T M -- Dinerman, J L -- Snyder, S H -- Kandel, E R -- Fishman, M C -- DA-00074/DA/NIDA NIH HHS/ -- DA-00266/DA/NIDA NIH HHS/ -- MH-45923/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1994 Jul 22;265(5171):542-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7518615" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Oxidoreductases/antagonists & inhibitors/genetics/*metabolism ; Animals ; Arginine/*analogs & derivatives/pharmacology ; Electric Stimulation ; Endothelium/enzymology ; Hippocampus/drug effects/enzymology/*physiology ; In Vitro Techniques ; *Long-Term Potentiation/drug effects ; Mice ; Mutation ; Nitric Oxide/*metabolism ; Nitric Oxide Synthase ; Nitroarginine ; Pyramidal Cells/drug effects/enzymology/*physiology ; Synaptic Transmission/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2011-03-26
    Description: Immunosuppressive tumor microenvironments can restrain antitumor immunity, particularly in pancreatic ductal adenocarcinoma (PDA). Because CD40 activation can reverse immune suppression and drive antitumor T cell responses, we tested the combination of an agonist CD40 antibody with gemcitabine chemotherapy in a small cohort of patients with surgically incurable PDA and observed tumor regressions in some patients. We reproduced this treatment effect in a genetically engineered mouse model of PDA and found unexpectedly that tumor regression required macrophages but not T cells or gemcitabine. CD40-activated macrophages rapidly infiltrated tumors, became tumoricidal, and facilitated the depletion of tumor stroma. Thus, cancer immune surveillance does not necessarily depend on therapy-induced T cells; rather, our findings demonstrate a CD40-dependent mechanism for targeting tumor stroma in the treatment of cancer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406187/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406187/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beatty, Gregory L -- Chiorean, Elena G -- Fishman, Matthew P -- Saboury, Babak -- Teitelbaum, Ursina R -- Sun, Weijing -- Huhn, Richard D -- Song, Wenru -- Li, Dongguang -- Sharp, Leslie L -- Torigian, Drew A -- O'Dwyer, Peter J -- Vonderheide, Robert H -- K08 CA138907/CA/NCI NIH HHS/ -- K12 CA076931/CA/NCI NIH HHS/ -- P30 CA016520/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2011 Mar 25;331(6024):1612-6. doi: 10.1126/science.1198443.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436454" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Animals ; Antibodies, Monoclonal/administration & dosage/adverse ; effects/metabolism/*therapeutic use ; Antigens, CD40/*agonists/*immunology ; Antineoplastic Agents/administration & dosage/adverse effects/*therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/*therapeutic use ; Carcinoma, Pancreatic Ductal/*drug therapy/immunology/pathology/secondary ; Deoxycytidine/analogs & derivatives/therapeutic use ; Disease Models, Animal ; Disease-Free Survival ; Female ; Humans ; Immunologic Surveillance ; Macrophage Activation ; Macrophages/immunology ; Male ; Mice ; Middle Aged ; Pancreatic Neoplasms/*drug therapy/immunology/pathology ; T-Lymphocytes/immunology ; Tumor Microenvironment ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2013-04-05
    Description: Author(s): Matteo Montagnese, Marian Otter, Xenophon Zotos, Dmitry A. Fishman, Nikolai Hlubek, Oleg Mityashkin, Christian Hess, Romuald Saint-Martin, Surjeet Singh, Alexandre Revcolevschi, and Paul H. M. van Loosdrecht Thirty-five years ago, Sanders and Walton [ Phys. Rev. B 15 1489 (1977)] proposed a method to measure the phonon-magnon interaction in antiferromagnets through thermal transport which so far has not been verified experimentally. We show that a dynamical variant of this approach allows direct extrac... [Phys. Rev. Lett. 110, 147206] Published Thu Apr 04, 2013
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
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  • 6
    Publication Date: 2013-06-18
    Description: Author(s): U. Nagel, Randy S. Fishman, T. Katuwal, H. Engelkamp, D. Talbayev, Hee Taek Yi, S.-W. Cheong, and T. Rõõm We have studied the magnetic field dependence of far-infrared active magnetic modes in a single ferroelectric domain BiFeO 3 crystal at low temperature. The modes soften close to the critical field of 18.8 T along the [001] (pseudocubic) axis, where the cycloidal structure changes to the homogeneous ... [Phys. Rev. Lett. 110, 257201] Published Mon Jun 17, 2013
    Keywords: Condensed Matter: Electronic Properties, etc.
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  • 7
    Publication Date: 2012-08-09
    Description: Author(s): M. Matsuda, R. S. Fishman, T. Hong, C. H. Lee, T. Ushiyama, Y. Yanagisawa, Y. Tomioka, and T. Ito We have determined the full magnetic dispersion relations of multiferroic BiFeO 3 . In particular, two excitation gaps originating from magnetic anisotropies have been clearly observed. The direct observation of the gaps enables us to accurately determine the Dzyaloshinskii-Moriya (DM) interaction and... [Phys. Rev. Lett. 109, 067205] Published Wed Aug 08, 2012
    Keywords: Condensed Matter: Electronic Properties, etc.
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  • 8
    Publication Date: 2011-08-24
    Description: Several gamma-ray bursts in the BATSE data have sufficiently long durations and complex temporal structures with pulses that appear to be spaced quasi-periodically. In order to test and quantify these periods we have applied fast Fourier transformations (FFT) to all these events. We have also performed cross spectral analyses of the FFT of the two extreme (high-low) energy bands in each case to determine the lead/lag of the pulses in different energies.
    Keywords: SPACE RADIATION
    Type: In: Gamma-ray bursts; Proceedings of the Workshop, Univ. of Alabama, Huntsville, Oct. 16-18, 1991 (A93-40051 16-93); p. 299-303.
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  • 9
    Publication Date: 2011-08-24
    Description: A cursory examination of cosmic gamma-ray burst time profiles indicates an inhomogeneous distribution of structure. In the first approximation, there seem to be two types of profiles; smooth ones with little structure and highly variable ones with lots of structure. To put this observation to the test, we have examined the statistical nature of the profile derivative to choose which parameter might best be called the burst 'spikiness'. We have found that a good estimator is given by a count of the number of 'spikes' (defined by a specific numerical recipe) and not by the rms deviations from either a pre-burst background or any type of moving average background. The application of this parameter to 30 burst time histories shows it to be consistent over a wide range of profile types. The analysis also reveals a preferred average time between spikes of approximately 1.5 seconds.
    Keywords: SPACE RADIATION
    Type: In: Gamma-ray bursts; Proceedings of the Workshop, Univ. of Alabama, Huntsville, Oct. 16-18, 1991 (A93-40051 16-93); p. 310-314.
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  • 10
    Publication Date: 2011-08-24
    Description: Most cosmic gamma-ray burst temporal profiles appear to be comprised of several individual pulses, many of which overlap. It is advantageous to deconvolve the temporal structures into their constituent pulses, and thereby investigate the shape, intensity and temporal distributions of the pulses as a function of energy. Such fundamental pulse descriptors would provide constraints for theoretical modeling of the burst emission process, such as indications of source size, optical depth and geometry, as a function of time. We have developed a deconvolution algorithm which treats sequences of pulse shapes that change deterministically. The algorithm, a generalization of autoregressive techniques, has been applied to a few bright bursts observed by BATSE. Results indicate that, even within short intervals, constituent pulses are not self-similarly shaped, nor do pulse shapes evolve in a simple manner throughout a burst. Hence, the direction of our future work on pulse deconvolution will focus on analysis methods which allow pulse shape to vary.
    Keywords: SPACE RADIATION
    Type: In: Gamma-ray bursts; Proceedings of the Workshop, Univ. of Alabama, Huntsville, Oct. 16-18, 1991 (A93-40051 16-93); p. 294-298.
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