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  • American Association for the Advancement of Science (AAAS)  (90)
  • Cambridge University Press
  • 2010-2014  (56)
  • 1995-1999  (49)
  • 1955-1959  (7)
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  • 1
    Publication Date: 1999-01-15
    Description: Phosphoinositide 3-kinase (PI3K) activation has been implicated in many cellular responses, including fibroblast growth, transformation, survival, and chemotaxis. Although PI3K is activated by several agents that stimulate T and B cells, the role of PI3K in lymphocyte function is not clear. The mouse gene encoding the PI3K adapter subunit p85alpha and its splice variants p55alpha and p50alpha was disrupted. Most p85alpha-p55alpha-p50alpha-/- mice die within days after birth. Lymphocyte development and function was studied with the use of the RAG2-deficient blastocyst complementation system. Chimeric mice had reduced numbers of peripheral mature B cells and decreased serum immunoglobulin. The B cells that developed had diminished proliferative responses to antibody to immunoglobulin M, antibody to CD40, and lipopolysaccharide stimulation and decreased survival after incubation with interleukin-4. In contrast, T cell development and proliferation was normal. This phenotype is similar to defects observed in mice lacking the tyrosine kinase Btk.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fruman, D A -- Snapper, S B -- Yballe, C M -- Davidson, L -- Yu, J Y -- Alt, F W -- Cantley, L C -- R01 GM041890/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Jan 15;283(5400):393-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. dfruman@bidmc.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9888855" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD45/analysis ; Apoptosis ; B-Lymphocytes/cytology/enzymology/*immunology ; Catalytic Domain ; Cell Cycle ; Chimera ; Chromones/pharmacology ; Enzyme Inhibitors/pharmacology ; Female ; Gene Targeting ; Immunoglobulins/*blood ; *Lymphocyte Activation ; Lymphocyte Count ; Male ; Mice ; Mice, Inbred C57BL ; Morpholines/pharmacology ; Phosphatidylinositol 3-Kinases/antagonists & inhibitors/genetics/*metabolism ; Protein-Tyrosine Kinases/genetics/metabolism ; Spleen/immunology ; T-Lymphocytes/cytology/enzymology/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1999-01-29
    Description: The subcrustal lithosphere underlying the southern Archean Churchill Province (ACP) in western Canada is at least one order of magnitude more electrically conductive than the lithosphere beneath adjacent Paleoproterozoic crust. The measured electrical properties of the lithosphere underlying most of the Paleoproterozoic crust can be explained by the conductivity of olivine. Mantle xenolith and geological mapping evidence indicate that the lithosphere beneath the southern ACP was substantially modified as a result of being trapped between two nearly synchronous Paleoproterozoic subduction zones. Tectonically induced metasomatism thus may have enhanced the subcrustal lithosphere conductivity of the southern ACP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boerner -- Kurtz -- Craven -- Ross -- Jones -- Davis -- New York, N.Y. -- Science. 1999 Jan 29;283(5402):668-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉D. E. Boerner and J. A. Craven, Geological Survey of Canada, 615 Booth Street, Ottawa, Ontario K1A OE9, Canada. R. D. Kurtz and W. J. Davis, Geological Survey of Canada, 601 Booth Street, Ottawa, Ontario K1A OE8, Canada. G. M. Ross, Geologica.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9924022" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 3
    Publication Date: 1999-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McLafferty, F W -- Fridriksson, E K -- Horn, D M -- Lewis, M A -- Zubarev, R A -- New York, N.Y. -- Science. 1999 May 21;284(5418):1289-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853-1301, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10383309" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Binding Sites ; DNA/*chemistry/isolation & purification/metabolism ; Mass Spectrometry/instrumentation/*methods ; Molecular Sequence Data ; Molecular Weight ; Proteins/*chemistry/isolation & purification/metabolism ; Sequence Analysis ; Sequence Analysis, DNA ; Thermodynamics ; Ubiquitins/chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2010-01-09
    Description: Recent observations of supernova remnants (SNRs) hint that they accelerate cosmic rays to energies close to ~10(15) electron volts. However, the nature of the particles that produce the emission remains ambiguous. We report observations of SNR W44 with the Fermi Large Area Telescope at energies between 2 x 10(8) electron volts and 3 x10(11) electron volts. The detection of a source with a morphology corresponding to the SNR shell implies that the emission is produced by particles accelerated there. The gamma-ray spectrum is well modeled with emission from protons and nuclei. Its steepening above approximately 10(9) electron volts provides a probe with which to study how particle acceleration responds to environmental effects such as shock propagation in dense clouds and how accelerated particles are released into interstellar space.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abdo, A A -- Ackermann, M -- Ajello, M -- Baldini, L -- Ballet, J -- Barbiellini, G -- Baring, M G -- Bastieri, D -- Baughman, B M -- Bechtol, K -- Bellazzini, R -- Berenji, B -- Blandford, R D -- Bloom, E D -- Bonamente, E -- Borgland, A W -- Bregeon, J -- Brez, A -- Brigida, M -- Bruel, P -- Burnett, T H -- Buson, S -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Casandjian, J M -- Cecchi, C -- Celik, O -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cognard, I -- Cohen-Tanugi, J -- Cominsky, L R -- Conrad, J -- Cutini, S -- Dermer, C D -- de Angelis, A -- de Palma, F -- Digel, S W -- do Couto e Silva, E -- Drell, P S -- Dubois, R -- Dumora, D -- Espinoza, C -- Farnier, C -- Favuzzi, C -- Fegan, S J -- Focke, W B -- Fortin, P -- Frailis, M -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gasparrini, D -- Gehrels, N -- Germani, S -- Giavitto, G -- Giebels, B -- Giglietto, N -- Giordano, F -- Glanzman, T -- Godfrey, G -- Grenier, I A -- Grondin, M-H -- Grove, J E -- Guillemot, L -- Guiriec, S -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Hays, E -- Hughes, R E -- Jackson, M S -- Johannesson, G -- Johnson, A S -- Johnson, T J -- Johnson, W N -- Kamae, T -- Katagiri, H -- Kataoka, J -- Katsuta, J -- Kawai, N -- Kerr, M -- Knodlseder, J -- Kocian, M L -- Kramer, M -- Kuss, M -- Lande, J -- Latronico, L -- Lemoine-Goumard, M -- Longo, F -- Loparco, F -- Lott, B -- Lovellette, M N -- Lubrano, P -- Lyne, A G -- Madejski, G M -- Makeev, A -- Mazziotta, M N -- McEnery, J E -- Meurer, C -- Michelson, P F -- Mitthumsiri, W -- Mizuno, T -- Monte, C -- Monzani, M E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nakamori, T -- Nolan, P L -- Norris, J P -- Noutsos, A -- Nuss, E -- Ohsugi, T -- Omodei, N -- Orlando, E -- Ormes, J F -- Paneque, D -- Parent, D -- Pelassa, V -- Pepe, M -- Pesce-Rollins, M -- Piron, F -- Porter, T A -- Raino, S -- Rando, R -- Razzano, M -- Reimer, A -- Reimer, O -- Reposeur, T -- Rochester, L S -- Rodriguez, A Y -- Romani, R W -- Roth, M -- Ryde, F -- Sadrozinski, H F-W -- Sanchez, D -- Sander, A -- Saz Parkinson, P M -- Scargle, J D -- Sgro, C -- Siskind, E J -- Smith, D A -- Smith, P D -- Spandre, G -- Spinelli, P -- Stappers, B W -- Stecker, F W -- Strickman, M S -- Suson, D J -- Tajima, H -- Takahashi, H -- Takahashi, T -- Tanaka, T -- Thayer, J B -- Thayer, J G -- Theureau, G -- Thompson, D J -- Tibaldo, L -- Tibolla, O -- Torres, D F -- Tosti, G -- Tramacere, A -- Uchiyama, Y -- Usher, T L -- Vasileiou, V -- Venter, C -- Vilchez, N -- Vitale, V -- Waite, A P -- Wang, P -- Winer, B L -- Wood, K S -- Yamazaki, R -- Ylinen, T -- Ziegler, M -- New York, N.Y. -- Science. 2010 Feb 26;327(5969):1103-6. doi: 10.1126/science.1182787. Epub 2010 Jan 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Space Science Division, Naval Research Laboratory, Washington, DC 20375, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20056857" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 5
    Publication Date: 2010-05-08
    Description: It is now possible to perform whole-genome shotgun sequencing as well as capture of specific genomic regions for extinct organisms. However, targeted resequencing of large parts of nuclear genomes has yet to be demonstrated for ancient DNA. Here we show that hybridization capture on microarrays can successfully recover more than a megabase of target regions from Neandertal DNA even in the presence of approximately 99.8% microbial DNA. Using this approach, we have sequenced approximately 14,000 protein-coding positions inferred to have changed on the human lineage since the last common ancestor shared with chimpanzees. By generating the sequence of one Neandertal and 50 present-day humans at these positions, we have identified 88 amino acid substitutions that have become fixed in humans since our divergence from the Neandertals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140021/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140021/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burbano, Hernan A -- Hodges, Emily -- Green, Richard E -- Briggs, Adrian W -- Krause, Johannes -- Meyer, Matthias -- Good, Jeffrey M -- Maricic, Tomislav -- Johnson, Philip L F -- Xuan, Zhenyu -- Rooks, Michelle -- Bhattacharjee, Arindam -- Brizuela, Leonardo -- Albert, Frank W -- de la Rasilla, Marco -- Fortea, Javier -- Rosas, Antonio -- Lachmann, Michael -- Hannon, Gregory J -- Paabo, Svante -- P01 CA013106/CA/NCI NIH HHS/ -- P01 CA013106-38/CA/NCI NIH HHS/ -- P01 CA013106-39/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 May 7;328(5979):723-5. doi: 10.1126/science.1188046.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20448179" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Animals ; Fossils ; Genes ; *Genome ; *Genome, Human ; Hominidae/*genetics ; Humans ; Nucleic Acid Hybridization ; Oligonucleotide Array Sequence Analysis/*methods ; Pan troglodytes/genetics ; Proteins/chemistry/genetics ; Sequence Alignment ; Sequence Analysis, DNA/*methods
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  • 6
    Publication Date: 2011-02-26
    Description: Despite being implicated as important intermediates, iron(V) compounds have proven very challenging to isolate and characterize. Here, we report the preparation of the iron(V) nitrido complex, [PhB((t)BuIm)(3)Fe(V) identical withN]BAr(F24) (PhB((t)BuIm)(3)(-) = phenyltris(3-tert-butylimidazol-2-ylidene)borato, BAr(F24) = B(3,5-(CF(3))(2)C(6)H(3))(4)(-)), by one electron oxidation of the iron(IV) nitrido precursor. Single-crystal x-ray diffraction of the iron(V) complex reveals a four-coordinate metal ion with a terminal nitrido ligand. Mossbauer and electron paramagnetic resonance spectroscopic characterization, supported by electronic structure calculations, provide evidence for a d(3) iron(V) metal center in a low spin (S = 1/2) electron configuration. Low-temperature reaction of the iron(V) nitrido complex with water under reducing conditions leads to high yields of ammonia with concomitant formation of an iron(II) species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scepaniak, Jeremiah J -- Vogel, Carola S -- Khusniyarov, Marat M -- Heinemann, Frank W -- Meyer, Karsten -- Smith, Jeremy M -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1049-52. doi: 10.1126/science.1198315.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, MSC 3C, New Mexico State University, Las Cruces, NM 88003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350172" target="_blank"〉PubMed〈/a〉
    Keywords: Crystallization ; Crystallography, X-Ray ; Electron Spin Resonance Spectroscopy ; Ferric Compounds/chemical synthesis/*chemistry ; Iron/*chemistry ; Ligands ; Molecular Structure ; Nitrogen/chemistry ; Oxidation-Reduction ; Physicochemical Processes ; Spectroscopy, Mossbauer
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  • 7
    Publication Date: 2011-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Silverman, Robert H -- Das Gupta, Jaydip -- Lombardi, Vincent C -- Ruscetti, Francis W -- Pfost, Max A -- Hagen, Kathryn S -- Peterson, Daniel L -- Ruscetti, Sandra K -- Bagni, Rachel K -- Petrow-Sadowski, Cari -- Gold, Bert -- Dean, Michael -- Mikovits, Judy A -- New York, N.Y. -- Science. 2011 Oct 14;334(6053):176. doi: 10.1126/science.334.6053.176-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21998366" target="_blank"〉PubMed〈/a〉
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  • 8
    Publication Date: 2011-09-24
    Description: In our 23 October 2009 Report, "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome," two of the coauthors, Silverman and Das Gupta, analyzed DNA samples from chronic fatigue syndrome (CFS) patients and healthy controls. A reexamination by Silverman and Das Gupta of the samples they used shows that some of the CFS peripheral blood mononuclear cell (PBMC) DNA preparations are contaminated with XMRV plasmid DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Silverman, Robert H -- Das Gupta, Jaydip -- Lombardi, Vincent C -- Ruscetti, Francis W -- Pfost, Max A -- Hagen, Kathryn S -- Peterson, Daniel L -- Ruscetti, Sandra K -- Bagni, Rachel K -- Petrow-Sadowski, Cari -- Gold, Bert -- Dean, Michael -- Mikovits, Judy A -- New York, N.Y. -- Science. 2011 Sep 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21940859" target="_blank"〉PubMed〈/a〉
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2012-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spiegel, Frederick W -- New York, N.Y. -- Science. 2012 Feb 17;335(6070):809-10. doi: 10.1126/science.1218515.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, SCEN 601, 1 University of Arkansas, Fayetteville, AR 72701, USA. fspiegel@uark.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22344435" target="_blank"〉PubMed〈/a〉
    Keywords: Cyanophora/*genetics ; *Evolution, Molecular ; *Genome, Plant ; Photosynthesis/*genetics
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  • 10
    Publication Date: 2013-07-06
    Description: After decades of vituperative debate over the classical or nonclassical structure of the 2-norbornyl cation, the long-sought x-ray crystallographic proof of the bridged, nonclassical geometry of this prototype carbonium ion in the solvated [C7H11](+)[Al2Br7](-) * CH2Br2 salt has finally been realized. This achievement required exceptional treatment. Crystals obtained by reacting norbornyl bromide with aluminum tribromide in CH2Br2 undergo a reversible order-disorder phase transition at 86 kelvin due to internal 6,1,2-hydride shifts of the 2-norbornyl cation moiety. Cooling with careful annealing gave a suitably ordered phase. Data collection at 40 kelvin and refinement revealed similar molecular structures of three independent 2-norbornyl cations in the unit cell. All three structures agree very well with quantum chemical calculations at the MP2(FC)/def2-QZVPP level of theory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scholz, F -- Himmel, D -- Heinemann, F W -- Schleyer, P v R -- Meyer, K -- Krossing, I -- New York, N.Y. -- Science. 2013 Jul 5;341(6141):62-4. doi: 10.1126/science.1238849.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Anorganische und Analytische Chemie, Albert-Ludwigs-Universitat Freiburg, Freiburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23828938" target="_blank"〉PubMed〈/a〉
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