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  • 2010-2014  (83)
  • 2000-2004  (141)
  • 1945-1949  (1)
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  • 1
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    Prognostic Impact of Cytogenetics and Early Response and Efficacy of Sequential High-Dose AraC and Idarubicin (S-HAI) in Patients with Refractory and Relapsed Acute Myeloid Leukemia (AML): Results of a Prospective Study. (2004)
    American Society of Hematology
    Details
    Publication Date: 2004-11-16
    Description: Management of patients with refractory and relapsed AML needs optimization. We performed a prospective study in these patients aiming at 1) the definition of the anti-leukemic efficacy of the S-HAI regimen; and 2) the evaluation of the prognostic impact of cytogenetic aberrations at relapse in the context of other prognostic parameters. Treatment consisted of AraC 1 g/sqm q 12 h days 1, 2, 8, and 9 and idarubicin 10 mg/sqm days 3, 4, 10, and 11. AraC was given at 3 g/sqm in patients under age 60 with refractory AML or relapse after CR1
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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    PAPER CURRENT
  • 2
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    Phosphorylation levels of JAK2 after addition of increasing Epo-concentrations: experimental data (Figure 5a) (2012)
    PANGAEA
    Details
    Publication Date: 2023-01-13
    Description: The present dataset data contain source data for Figure 5a from Schilling et al., 2009. Cell fate decisions are regulated by the coordinated activation of signalling pathways such as the extracellular signal-regulated kinase (ERK) cascade, but contributions of individual kinase isoforms are mostly unknown. The authors combined quantitative data from erythropoietin-induced pathway activation in primary erythroid progenitor (colony-forming unit erythroid stage, CFU-E) cells with mathematical modelling, in order to predict and experimentally confirmed a distributive ERK phosphorylation mechanism in CFU-E cells. The authors found evidences that double-phosphorylated ERK1 attenuates proliferation beyond a certain activation level, whereas activated ERK2 enhances proliferation with saturation kinetics. CFU-E cells were stimulated with the indicated Epo concentrations for 7 min and phosphorylation levels were determined by quantitative immunoblotting.
    Keywords: Amount concentration (molecules in cells), of phosphorylated Janus Activated Kinase 2; Event label; Experiment_pJAK2; Treatment: chemical concentration (biological activity), of Erythropoietin
    Type: Dataset
    Format: text/tab-separated-values, 30 data points
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    DATA PANGAEA
  • 3
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    Phosphorylation levels of JAK2 after addition of increasing Epo-concentrations: model approach (Figure 5a) (2012)
    PANGAEA
    Details
    Publication Date: 2023-01-13
    Description: The present dataset contain source data for Figure 5a from Schilling et al., 2009. Cell fate decisions are regulated by the coordinated activation of signalling pathways such as the extracellular signal-regulated kinase (ERK) cascade, but contributions of individual kinase isoforms are mostly unknown. The authors combined quantitative data from erythropoietin-induced pathway activation in primary erythroid progenitor (colony-forming unit erythroid stage, CFU-E) cells with mathematical modelling, in order to predict and experimentally confirmed a distributive ERK phosphorylation mechanism in CFU-E cells. The authors found evidences that double-phosphorylated ERK1 attenuates proliferation beyond a certain activation level, whereas activated ERK2 enhances proliferation with saturation kinetics. Phosphorylation levels of JAK2 at 7 min after stimulation for Epo concentrations ranging from 0.1 to 1000 U/ml were simulated.
    Keywords: Amount concentration (molecules in cells), of phosphorylated Janus Activated Kinase 2; Event label; Model_pJAK2; Treatment: chemical concentration (biological activity), of Erythropoietin
    Type: Dataset
    Format: text/tab-separated-values, 206 data points
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    DATA PANGAEA
  • 4
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    Proliferation of retrovirally transduced CFU-E cells after incubation with increasing Epo-concentration (Figure 5c) (2012)
    PANGAEA
    Details
    Publication Date: 2023-01-13
    Description: Data contain source data for Figure 5c from Schilling et al., 2009. Cell fate decisions are regulated by the coordinated activation of signalling pathways such as the extracellular signal-regulated kinase (ERK) cascade, but contributions of individual kinase isoforms are mostly unknown. The authors combined quantitative data from erythropoietin-induced pathway activation in primary erythroid progenitor (colony-forming unit erythroid stage, CFU-E) cells with mathematical modelling, in order to predict and experimentally confirmed a distributive ERK phosphorylation mechanism in CFU-E cells. The authors found evidences that double-phosphorylated ERK1 attenuates proliferation beyond a certain activation level, whereas activated ERK2 enhances proliferation with saturation kinetics. Retrovirally transduced CFU-E cells were incubated with increasing Epo concentrations for 14 h and proliferation was measured by [3H]-thymidine incorporation.
    Keywords: Detector raw counts; Event label; Experiment_ppERK_Treatment_a; Experiment_ppERK_Treatment_b; Experiment_ppERK_Treatment_c; Experiment_ppERK_Treatment_d; Thymidine incorporation; Treatment: Amount concentration, of Extracellular signal-Regulated Kinase 1; Treatment: Amount concentration, of Extracellular signal-Regulated Kinase 2; Treatment: Amount concentration, protein kinase B; Treatment: chemical concentration (biological activity), of Erythropoietin
    Type: Dataset
    Format: text/tab-separated-values, 800 data points
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    DATA PANGAEA
  • 5
    Electronic Resource
    Electronic Resource
    A melon genotype with superior competence for regeneration and transformation (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 122 (2003), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Transformation efficiency of melon is low and is still regarded as a challenge. In this paper, the regeneration and transformation response of ‘BU-21/3′, a newly characterized melon breeding line, is described. The line seems to be superior in this regard to previously evaluated genotypes. Agrobacterium-mediated delivery of the GUS or GFP reporter genes into cotyledon explants was used to evaluate efficiency of transient and stable transformation. Good transient expression was observed, and stable transformation frequencies of 0.4-1.5 transgenic shoots per explant were obtained. Transgenic plantlets were transferred to a contained greenhouse as early as 8-10 weeks after transformation. Transgenic plants are fertile and exhibit a true-to-type phenotype. The ‘BU-21/3’ line may become a useful tool for the facilitation of transgenic breeding in melon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0523.2003.00764.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Live birth after ovarian tissue transplant (2004)
    [s.l.] : Nature Publishing Group
    Nature 428 (2004), S. 137-138 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Radiation and high-dose chemotherapy may render women with cancer prematurely sterile, a side-effect that would be avoided if ovarian tissue that had been removed before treatment could be made to function afterwards. Live offspring have been produced from transplanted ovarian tissue in mice ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/428137a
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  • 7
    Electronic Resource
    Electronic Resource
    Inclusion of HNEt3+ in an acyclic tetraphenolate (2000)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 56 (2000), S. 997-998 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The acyclic tetraphenolic derivative 2,2′-methylenebis[6-(3-tert-butyl-2-hydroxy-5-methylbenzyl)-4-methylphenol] reacts with excess triethylamine in acetonitrile to form a molecular complex, i.e. triethylammonium 2-(3-tert-butyl-2-hydroxy-5-methylbenzyl)-6-[3-(3-tert-butyl-2-hydroxy-5-methylbenzyl)-2-hydroxy-5-methylbenzyl]-4-methylphenolate acetonitrile solvate, C6H16N+·C39H47O4−·C2H3N, where the organic HNEt3+ cation is included in the partial cone defined by the aromatic faces of the acyclic polyphenolate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270100006582
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  • 8
    Electronic Resource
    Electronic Resource
    Study on the pathophysiology of experimental Burkholderia pseudomallei infection in mice (2001)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 30 (2001), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Burkholderia pseudomallei is the etiological agent of melioidosis, a potentially fatal disease occurring in man and animals. The aim of this study was to investigate the pathophysiological course of experimental melioidosis, and to identify the target organs, in an animal model. For this purpose SWISS mice were infected intraperitoneally with the virulent strain B. pseudomallei 6068. The bacterial load of various organs was quantified daily by bacteriological analysis and by an enzyme-linked immunosorbent assay (ELISA) based on a monoclonal antibody specific to B. pseudomallei exopolysaccharide (EPS). Electron microscopic investigation of the spleen was performed to locate the bacteria at the cellular level. In this model of acute melioidosis, B. pseudomallei had a marked organ tropism for liver and spleen, and showed evidence of in vivo growth with a bacterial burden of 1.6×109 colony forming units (CFU) per gram of spleen 5 days after infection with 200 CFU. The highest bacterial loads were detected in the spleen at all time points, in a range from 2×106 to 2×109 CFU g−1. They were still 50–80 times greater than the load of the liver at the time of peak burden. Other investigated organs such as lungs, kidneys, and bone marrow were 102–104-fold less infected than the spleen, with loads ranging from 3×102 to 3×106 CFU g−1. The heart and the brain were sites of a delayed infection, with counts in a range from 103 to 107 times lower than bacterial counts in the spleen. The EPS-specific ELISA proved to be highly sensitive, particularly at the level of those tissues in which colony counting on agar revealed low contamination. In the blood, EPS was detected at concentrations corresponding to bacterial loads ranging from 8×103 to 6×104 CFU ml−1. Electron microscopic examination of the spleen revealed figures of phagocytosis, and the presence of large numbers of intact bacteria, which occurred either as single cells or densely packed into vacuoles. Sparse figures suggesting bacterial replication were also observed. In addition, some bacteria could be seen in vacuoles that seemed to have lost their membrane. These observations provide a basis for further investigations on the pathogenesis of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-695X.2001.tb01550.x
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  • 9
    Electronic Resource
    Electronic Resource
    Evaluation of a standardized F1 capsular antigen capture ELISA test kit for the rapid diagnosis of plague (2004)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 41 (2004), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Rapid detection of soluble F1 capsular antigen in serum, bubo fluid or urine of patients proved to be a valuable tool in the presumptive diagnosis of plague.We evaluated a F1 capsular antigen capture ELISA resembling a commercially available test kit. The minimal detectable concentration was 4 ng/ml. The specificity was 100% when investigating 47 sera from healthy Malagasy subjects and 98.4% when 365 sera from German blood donors were studied. Sensitivity was determined on sera (n=11) and buboes (n=18) from bacteriologically confirmed Malagasy plague patients. Sensitivity was 90.1% for serum and 100% for buboes.A standardized F1 capsular antigen capture ELISA test kit might be well suited for the early detection of plague particularly in non-endemic areas where clinical microbiological laboratories have only limited access to alternative techniques for rapid identification of Yersinia pestis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsim.2004.02.005
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  • 10
    Electronic Resource
    Electronic Resource
    Atomic Structure and Properties of the (310) Symmetrical Tilt Grain Boundary (STGB) in SrTiO3. Part I: Atomistic Simulations (2000)
    Springer
    Interface science 8 (2000), S. 157-175 
    Details
    ISSN: 1573-2746
    Keywords: grain boundaries ; atomistic simulations ; atomic structure ; SrTiO3 ; grain boundary energy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The relaxed structure and energy of the (310) symmetrical tilt grain boundary (STGB) in SrTiO3 have been calculated using static lattice energy minimization methods. In principle, the (310) GB plane can either be a cation-rich, positively charged “SrTiO” plane or a negatively charged oxygen plane, and both scenarios have been considered in this report. The effect of point-defect reconstruction at the GB core region, manifested either as completely missing columns or as half-filled columns of ions as suggested by experiments, has been analyzed. The results indicate that while Schottky defects are very strongly preferred energetically at the GB core, there is not significant gain in energy by having half-filled columns, as opposed to fully-dense and fully-empty columns, at the GB core. The simulation results have been analyzed in the context of Pauling's rules of crystal chemistry and bicrystallography. The results form the basis for an objective comparison with experimental studies in Part II of the paper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008715125452
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