Publication Date:
2014-12-17
Description:
Stochasticity inherent to biochemical reactions (intrinsic noise) and variability in cellular states (extrinsic noise) degrade information transmitted through signaling networks. We analyzed the ability of temporal signal modulation--that is, dynamics--to reduce noise-induced information loss. In the extracellular signal-regulated kinase (ERK), calcium (Ca(2+)), and nuclear factor kappa-B (NF-kappaB) pathways, response dynamics resulted in significantly greater information transmission capacities compared to nondynamic responses. Theoretical analysis demonstrated that signaling dynamics has a key role in overcoming extrinsic noise. Experimental measurements of information transmission in the ERK network under varying signal-to-noise levels confirmed our predictions and showed that signaling dynamics mitigate, and can potentially eliminate, extrinsic noise-induced information loss. By curbing the information-degrading effects of cell-to-cell variability, dynamic responses substantially increase the accuracy of biochemical signaling networks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Selimkhanov, Jangir -- Taylor, Brooks -- Yao, Jason -- Pilko, Anna -- Albeck, John -- Hoffmann, Alexander -- Tsimring, Lev -- Wollman, Roy -- P50 GM085764/GM/NIGMS NIH HHS/ -- P50-GM085764/GM/NIGMS NIH HHS/ -- R01 GM089976/GM/NIGMS NIH HHS/ -- R01-GM071573/GM/NIGMS NIH HHS/ -- R01-GM089976/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2014 Dec 12;346(6215):1370-3. doi: 10.1126/science.1254933.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bioengineering, University of California-San Diego, La Jolla, CA 92093, USA. ; Department of Chemistry and Biochemistry, University of California-San Diego, La Jolla, CA 92093, USA. ; Department of Molecular and Cellular Biology, University of California-Davis, Davis 95616, USA. ; San Diego Center for Systems Biology, La Jolla, CA 92093, USA. Institute for Quantitative and Computational Biosciences and Department of Microbiology, Immunology, and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA 90025, USA. ; San Diego Center for Systems Biology, La Jolla, CA 92093, USA. BioCircuits Institute, University of California-San Diego, La Jolla, CA 92093, USA. ; Department of Chemistry and Biochemistry, University of California-San Diego, La Jolla, CA 92093, USA. San Diego Center for Systems Biology, La Jolla, CA 92093, USA. Cell and Developmental Biology Section, Division of Biological Sciences, University of California-San Diego, La Jolla, CA 92093, USA. rwollman@ucsd.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25504722" target="_blank"〉PubMed〈/a〉
Keywords:
*Calcium Signaling
;
Cell Line
;
Computer Simulation
;
Extracellular Signal-Regulated MAP Kinases/*metabolism
;
Humans
;
*MAP Kinase Signaling System
;
NF-kappa B/*metabolism
;
*Signal Transduction
;
Signal-To-Noise Ratio
;
Single-Cell Analysis
;
Systems Biology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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