Publikationsdatum:
2015-10-10
Beschreibung:
Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing the evolutionary history of anatomically modern humans. However, historic migrations from Eurasia into Africa have affected many contemporary populations, confounding inferences. Here, we present a 12.5x coverage ancient genome of an Ethiopian male ("Mota") who lived approximately 4500 years ago. We use this genome to demonstrate that the Eurasian backflow into Africa came from a population closely related to Early Neolithic farmers, who had colonized Europe 4000 years earlier. The extent of this backflow was much greater than previously reported, reaching all the way to Central, West, and Southern Africa, affecting even populations such as Yoruba and Mbuti, previously thought to be relatively unadmixed, who harbor 6 to 7% Eurasian ancestry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallego Llorente, M -- Jones, E R -- Eriksson, A -- Siska, V -- Arthur, K W -- Arthur, J W -- Curtis, M C -- Stock, J T -- Coltorti, M -- Pieruccini, P -- Stretton, S -- Brock, F -- Higham, T -- Park, Y -- Hofreiter, M -- Bradley, D G -- Bhak, J -- Pinhasi, R -- Manica, A -- Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2015 Nov 13;350(6262):820-2. doi: 10.1126/science.aad2879. Epub 2015 Oct 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. mg632@cam.ac.uk joneser@tcd.ie ron.pinhasi@ucd.ie am315@cam.ac.uk. ; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. mg632@cam.ac.uk joneser@tcd.ie ron.pinhasi@ucd.ie am315@cam.ac.uk. ; Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. Integrative Systems Biology Laboratory, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia. ; Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. ; Department of Society, Culture, and Language, University of South Florida St. Petersburg, 140 7th Avenue South, St. Petersburg, FL 33701, USA. ; Department of Anthropology, Ventura College, 4667 Telegraph Road, Ventura, CA 93003, USA. Humanities and Social Sciences Program, UCLA Extension, University of California Los Angeles, 10995 Le Conte Avenue, Los Angeles, CA 90095, USA. ; Department of Archaeology and Anthropology, University of Cambridge, Pembroke Street, Cambridge CB2 3QG, UK. ; Department of Physical Sciences, Earth and Environment, University of Siena, Via di Laterina, 8-53100 Siena, Italy. ; Department of Anthropology, University of Illinois at Urbana-Champaign, Public Service Archaeology and Architecture Program, 109 Davenport Hall, 607 South Mathews Avenue, Urbana, IL 61801, USA. ; Oxford Radiocarbon Accelerator Unit, Research Laboratory for Archaeology and the History of Art, University of Oxford, Dyson Perrins Building, South Parks Road, Oxford OX1 3QY, UK. Cranfield Forensic Institute, Cranfield University, Defence Academy of the United Kingdom, Shrivenham, Oxon SN6 8LA, UK. ; Oxford Radiocarbon Accelerator Unit, Research Laboratory for Archaeology and the History of Art, University of Oxford, Dyson Perrins Building, South Parks Road, Oxford OX1 3QY, UK. ; Theragen BiO Institute, 2nd Floor B-dong, AICT bldg, Iui-dong, Youngtong-gu, Suwon 443-270, Republic of Korea. ; Institute for Biochemistry and Biology, Faculty for Mathematics and Natural Sciences, University of Potsdam, Karl-Liebknechtstrasse 24-25, 14476 Potsdam Golm, Germany. Department of Biology, University of York, Wentworth Way, Heslington, York YO10 5DD, UK. ; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. ; The Genomics Institute, Ulsan National Institute of Science and Technology, Ulsan 689-798, Republic of Korea. ; School of Archaeology and Earth Institute, University College Dublin, Dublin 4, Ireland. mg632@cam.ac.uk joneser@tcd.ie ron.pinhasi@ucd.ie am315@cam.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26449472" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
African Continental Ancestry Group/*genetics
;
Asia
;
Biological Evolution
;
Ethiopia
;
Europe
;
Genetic Variation
;
*Genome, Human
;
*Human Migration
;
Humans
;
Male
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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