Publication Date:
2015-09-05
Description:
During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells are unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8(+) T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8(+) T cell recruitment and effector functions. Collectively, these results suggest that neutrophils deposit long-lasting, chemokine-containing trails, which may provide both chemotactic and haptotactic cues for efficient CD8(+) T cell migration and localization in influenza-infected tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lim, Kihong -- Hyun, Young-Min -- Lambert-Emo, Kris -- Capece, Tara -- Bae, Seyeon -- Miller, Richard -- Topham, David J -- Kim, Minsoo -- AI102851/AI/NIAID NIH HHS/ -- HHSN272201400005C/PHS HHS/ -- HL087088/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2015 Sep 4;349(6252):aaa4352. doi: 10.1126/science.aaa4352.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA. ; Department of Pharmacology, Northwestern University, Chicago, IL, USA. ; Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA. minsoo_kim@urmc.rochester.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26339033" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
CD8-Positive T-Lymphocytes/*immunology
;
Chemokine CXCL12/*immunology/pharmacology
;
Chemotaxis/*immunology
;
Heterocyclic Compounds/pharmacology
;
Influenza A virus/*immunology
;
Lung/immunology/virology
;
Male
;
Matrix Metalloproteinase 2/immunology
;
Matrix Metalloproteinase 9/immunology
;
Mice
;
Mice, Inbred C57BL
;
Neutropenia/immunology
;
Neutrophils/*immunology/virology
;
Orthomyxoviridae Infections/*immunology
;
Trachea/*immunology/virology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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