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  • 2015-2019  (268)
  • 1995-1999  (190)
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  • 1
    Publication Date: 2019-09-03
    Description: Hepatitis C virus (HCV) is a highly variable pathogen that frequently establishes chronic infection. This genetic variability is affected by the adaptive immune response but the contribution of other host factors is unclear. Here, we examined the role played by interferon lambda-4 (IFN-λ4) on HCV diversity; IFN-λ4 plays a crucial role in spontaneous clearance or establishment of chronicity following acute infection. We performed viral genome-wide association studies using human and viral data from 485 patients of white ancestry infected with HCV genotype 3a. We demonstrate that combinations of host genetic variants, which determine IFN-λ4 protein production and activity, influence amino acid variation across the viral polyprotein - not restricted to specific viral proteins or HLA restricted epitopes - and modulate viral load. We also observed an association with viral di-nucleotide proportions. These results support a direct role for IFN-λ4 in exerting selective pressure across the viral genome, possibly by a novel mechanism.
    Electronic ISSN: 2050-084X
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
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    PANGAEA
    In:  Supplement to: Schultz, Martin G; Schröder, Sabine; Lyapina, Olga; Cooper, Owen R; Galbally, Ian; Petropavlovskikh, Irina; von Schneidemesser, Erika; Tanimoto, Hiroshi; Elshorbany, Yasin; Naja, Manish; Seguel, Rodrigo J; Dauert, Ute; Eckhardt, Paul; Feigenspan, Stefan; Fiebig, Markus; Hjellbrekke, Anne-Gunn; Hong, You-Deog; Kjeld, Peter Christian; Koide, Hiroshi; Lear, Gary; Tarasick, David; Ueno, Mikio; Wallasch, Markus; Baumgardner, Darrel; Chuang, Ming-Tung; Gillett, Robert; Lee, Meehye; Molloy, Suzie; Moolla, Raeesa; Wang, Tao; Sharps, Katrina; Adame, Jose A; Ancellet, Gerard; Apadula, Francesco; Artaxo, Paulo; Barlasina, Maria E; Bogucka, Magdalena; Bonasoni, Paolo; Chang, Limseok; Colomb, Aurelie; Cuevas-Agulló, Emilio; Cupeiro, Manuel; Degorska, Anna; Ding, Aijun; Fröhlich, Marina; Frolova, Marina; Gadhavi, Harish; Gheusi, Francois; Gilge, Stefan; Gonzalez, Margarita Y; Gros, Valérie; Hamad, Samera H; Helmig, Detlev; Henriques, Diamantino; Hermansen, Ove; Holla, Robert; Hueber, Jacques; Im, Ulas; Jaffe, Daniel A; Komala, Ninong; Kubistin, Dagmar; Lam, Ka-Se; Laurila, Tuomas; Lee, Haeyoung; Levy, Ilan; Mazzoleni, Claudio; Mazzoleni, Lynn R; McClure-Begley, Audra; Mohamad, Maznorizan; Murovec, Marijana; Navarro-Comas, Monica; Nicodim, Florin; Parrish, David; Read, Katie Alana; Reid, Nick; Ries, Ludwig; Saxena, Pallavi; Schwab, James J; Scorgie, Yvonne; Senik, Irina; Simmonds, Peter; Sinha, Vinayak; Skorokhod, Andrey I; Spain, Gerard; Spangl, Wolfgang; Spoor, Ronald; Springston, Stephen R; Steer, Kelvyn; Steinbacher, Martin; Suharguniyawan, Eka; Torre, Paul; Trickl, Thomas; Weili, Lin; Weller, Rolf; Xu, Xiaobin; Xue, Likun; Ma, Zhiqiang (2017): Tropospheric Ozone Assessment Report: Database and Metrics Data of Global Surface Ozone Observations. Elementa - Science of the Anthropocene, 5:58, 26 pp, https://doi.org/10.1525/elementa.244
    Publication Date: 2023-11-18
    Description: In support of the first Tropospheric Ozone Assessment Report (TOAR) a relational database of global surface ozone observations has been developed and populated with hourly measurement data and enhanced metadata. A comprehensive suite of ozone metrics products including standard statistics, health and vegetation impact metrics, and trend information, are made available through a common data portal and a web interface. These data form the basis of the TOAR analyses focusing on human health, vegetation, and climate relevant ozone issues, which are part of this special feature. By combining the data from almost 10,000 measurement sites around the world with global metadata information, new analyses of surface ozone have become possible, such as the first globally consistent characterisations of measurement sites as either urban or rural/remote. Exploitation of these global metadata allow for new insights into the global distribution, and seasonal and long-term changes of tropospheric ozone. Cooperation among many data centers and individual researchers worldwide made it possible to build the world's largest collection of in-situ hourly surface ozone data covering the period from 1970 to 2015. Considerable effort was made to harmonize and synthesize data formats and metadata information from various networks and individual data submissions. Extensive quality control was applied to identify questionable and erroneous data, including changes in apparent instrument offsets or calibrations. Such data were excluded from TOAR data products. Limitations of a posteriori data quality assurance are discussed. As a result of the work presented here, global coverage of surface ozone data has been significantly extended. Yet, large gaps remain in the surface observation network both in terms of regions without monitoring, and in terms of regions that have monitoring programs but no public access to the data archive. Therefore future improvements to the database will require not only improved data harmonization, but also expanded data sharing and increased monitoring in data-sparse regions.
    Keywords: TOAR; Tropospheric Ozone Assessment Report
    Type: Dataset
    Format: application/zip, 7 datasets
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  • 3
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Corporate governance 7 (1999), S. 0 
    ISSN: 1467-8683
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Political Science , Economics
    Notes: Clauses in company articles giving boards rather than shareholders the power to remove directors, can give either the chairman or chief executive the power to retain their tenure even when performance is less than satisfactory. A power holder can simply remove opposition from a board as soon as it is expressed. When used ruthlessly, such power makes it almost impossible for independent non-executive directors to carry out their most important role of monitoring executive directors and removing non-performers at an early stage. Machiavelli claimed that extension of tenure was a prime cause of Rome’s decline. He argued persuasively for fixed terms, with no variation possible. The prohibition of removal clauses, and the introduction of fixed director terms might well increase corporate performance by preventing continued tenure for those who have failed.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 85 (1999), S. 893-896 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The central-cell correction has been determined experimentally for the two donor impurities S and Si in GaAs. Data have been obtained for magnetic fields to 39 T, corresponding to γ(approximate)6. The observed behavior is in good agreement with theory. The analysis permits accurate evaluation of zero-field central-cell corrections, yielding 0.110 and 0.059 meV for S and Si, respectively. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    Assembly automation 15 (1995), S. 9-11 
    ISSN: 0144-5154
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Explores the use of "enhanced reality" to achieve the ideal ofinstruments coupling humans into tasks which defy direct human interactions.Looks at the use of intelligent imaging systems [IIS] in sensing the realworld and creating a model of the complete task in a form that humans can useto perform the task easily and effectively. Discusses the importance ofimproved human computer interfacing and data visualization and concludes byoutlining future developments in intelligent imaging systems.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 397 (1999), S. 485-485 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Backhaus et al. reply — Avenel et al. have suggested a mechanism that might explain the recently discovered metastable π-state in a superfluid 3He weak-link array. We are pleased that our experiment is leading to new ideas that may extend the understanding of weak-link ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 375 (1995), S. 637-637 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Infants born to HIV-infected mothers acquire maternal antibody trans-placentally, rendering the interpretation of serological assays difficult. Secure diagnosis of perinatal infection should include investigation both of a maternal sample and of two or more infant ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 396 (1998), S. 554-557 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Waves on the surface of a fluid provide a powerful tool for studying the fluid itself and the surrounding physical environment. For example, the wave speed is determined by the force per unit mass at the surface, and by the depth of the fluid: the decreasing speed of ocean waves as they ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 392 (1998), S. 687-690 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Under certain circumstances,, a superconducting Josephson junction can maintain a quantum phase difference of π between the two samples that are weakly connected to form the junction. Such systems are called ‘π-junctions’ and have formed the basis of several experiments ...
    Type of Medium: Electronic Resource
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