Publication Date:
2004-01-24
Description:
Mammalian sex chromosomes have undergone profound changes since evolving from ancestral autosomes. By examining retroposed genes in the human and mouse genomes, we demonstrate that, during evolution, the mammalian X chromosome has generated and recruited a disproportionately high number of functional retroposed genes, whereas the autosomes experienced lower gene turnover. Most autosomal copies originating from X-linked genes exhibited testis-biased expression. Such export is incompatible with mutational bias and is likely driven by natural selection to attain male germline function. However, the excess recruitment is consistent with a combination of both natural selection and mutational bias.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Emerson, J J -- Kaessmann, Henrik -- Betran, Esther -- Long, Manyuan -- GM-065429-01A1/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Jan 23;303(5657):537-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14739461" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Biological Evolution
;
Chromosomes, Human/genetics
;
Chromosomes, Human, X/*genetics
;
Chromosomes, Mammalian/genetics
;
Computational Biology
;
Dosage Compensation, Genetic
;
Female
;
Gene Expression Profiling
;
Genes, Duplicate
;
Genetic Linkage
;
Genome
;
Genome, Human
;
Humans
;
Introns
;
Male
;
Mice
;
Monte Carlo Method
;
Mutation
;
Oligonucleotide Array Sequence Analysis
;
Ovary/metabolism
;
Pseudogenes/*genetics
;
*Recombination, Genetic
;
Retroelements/*genetics
;
Selection, Genetic
;
Sex Characteristics
;
Testis/metabolism
;
X Chromosome/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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