ALBERT

Description: Introduction The current standard to assess chemotherapy tolerability relies on patient self-reporting. However, as the sole mechanism of managing symptom burden, this may be inconsistent and fraught with bias. Mobile wearable health devices have the ability to monitor and aggregate objective activity and sleep data over long periods of time, but have not been systematically used in the oncology clinic. The aim of the study was to assess whether the use of mobile wearable technology establishes patterns of "sleep" and "wake" states in newly diagnosed Multiple Myeloma (NDMM) patients receiving therapy, and whether these patterns differ over time. Methods Patients presenting to the myeloma clinic at Memorial Sloan Kettering Cancer Center (MSKCC) with a new diagnosis of Multiple Myeloma and smart phone or tablet (iOS or Android) compatible with the Garmin Vivofit device were offered to participate in a mobile wearable bio-monitoring study. All eligible participants were required to receive primary chemotherapy treatment at a MSKCC facility. Treatment was determined by physician. NDMM patients were assigned to one of two cohorts (20 in each; Cohort A - patients

Description: Haiti has suffered great losses from deforestation, with little forest cover remaining today. Current reforestation efforts focus on seedling quantity rather than quality. This study examined limitations to the production of high-quality seedlings of the endemic Hispaniolan pine (Pinus occidentalis Swartz). Recognizing the importance of applying sustainable development principles to pine forest restoration, the effects of growing media and container types on seedling growth were evaluated with the goal of developing a propagation protocol to produce high-quality seedlings using economically feasible nursery practices. With regard to growing media, seedlings grew best in compost-based media amended with sand. Topsoil, widely used in nurseries throughout Haiti, produced the smallest seedlings overall. Despite a low water holding capacity and limited manganese, compost-based media provided adequate levels of essential mineral nutrients (particularly nitrogen), which allowed for sufficient seedling nutrition. Seedling shoot and root growth, as well as the ratio of shoot biomass to root biomass, were greater in polybags relative to D40s. Results indicate that economically feasible improvements to existing nursery practices in Haiti can improve the early growth rates of P. occidentalis seedlings.

Description: The Antarctic Centennial Oscillation (ACO) is a paleoclimate temperature cycle that originates in the Southern Hemisphere, is the presumptive evolutionary precursor of the contemporary Antarctic Oscillation (AAO), and teleconnects to the Northern Hemisphere to influence global temperature. In this study we investigate the internal climate dynamics of the ACO over the last 21 millennia using stable water isotopes frozen in ice cores from 11 Antarctic drill sites as temperature proxies. Spectral and time series analyses reveal that ACOs occurred at all 11 sites over all time periods evaluated, suggesting that the ACO encompasses all of Antarctica. From the Last Glacial Maximum through the Last Glacial Termination (LGT), ACO cycles propagated on a multicentennial time scale from the East Antarctic coastline clockwise around Antarctica in the streamline of the Antarctic Circumpolar Current (ACC). The velocity of teleconnection (VT) is correlated with the geophysical characteristics of drill sites, including distance from the ocean and temperature. During the LGT, the VT to coastal sites doubled while the VT to inland sites decreased fourfold, correlated with increasing solar insolation at 65°N. These results implicate two interdependent mechanisms of teleconnection, oceanic and atmospheric, and suggest possible physical mechanisms for each. During the warmer Holocene, ACOs arrived synchronously at all drill sites examined, suggesting that the VT increased with temperature. Backward extrapolation of ACO propagation direction and velocity places its estimated geographic origin in the Southern Ocean east of Antarctica, in the region of the strongest sustained surface wind stress over any body of ocean water on Earth. ACO period is correlated with all major cycle parameters except cycle symmetry, consistent with a forced, undamped oscillation in which the driving energy affects all major cycle metrics. Cycle period and symmetry are not discernibly different for the ACO and AAO over the same time periods, suggesting that they are the same climate cycle. We postulate that the ACO/AAO is generated by relaxation oscillation of Westerly Wind velocity forced by the equator-to-pole temperature gradient and propagated regionally by identified air-sea-ice interactions.

Description: Circadian rhythms allow an organism to synchronize internal physiological responses to the external environment. Perception of external signals such as light and temperature are critical in the entrainment of the oscillator. However, sugar can also act as an entraining signal. In this work, we have confirmed that sucrose accelerates the circadian period, but this observed effect is dependent on the reporter gene used. This observed response was dependent on sucrose being available during free-running conditions. If sucrose was applied during entrainment, the circadian period was only temporally accelerated, if any effect was observed at all. We also found that sucrose acts to stabilize the robustness of the circadian period under red light or blue light, in addition to its previously described role in stabilizing the robustness of rhythms in the dark. Finally, we also found that CCA1 is required for both a short- and long-term response of the circadian oscillator to sucrose, while LHY acts to attenuate the effects of sucrose on circadian period. Together, this work highlights new pathways for how sucrose could be signaling to the oscillator and reveals further functional separation of CCA1 and LHY.

Description: Subirrigation (SI), where water is provided to container seedlings from below and rises through the growing media via capillary action, is regarded as an environmentally-responsible method of delivering water and fertilizer to nursery-grown plants, resulting in more uniform crops and improved production efficiency. While a concern around adopting this method is that a potential higher salt concentration in the upper layers of growing media under SI may inhibit root growth and result in decreased plant quality, few studies have focused on how root morphology is altered by SI. Therefore, a balanced two-factor factorial design with three rates of fertilization (50, 100, and 150 mg N seedling−1) and two irrigation methods (SI or overhead irrigation (OI)) was used to examine the growth response of Prince Rupprecht’s larch (Larix principis-rupprechtii Mayr) seedlings for one nursery season. Associated changes between rhizosphere electrical conductivity (EC) and root morphology of different root size classes were analyzed. Results show that (1) height, root-collar diameter, and root volume were similar between seedlings grown under SI and OI. However, (2) compared to seedlings receiving OI, SI-seedlings had less root mass, length, and surface area but greater average root diameter (ARD). (3) Morphological differences were evident primarily in root diameter size classes I–III (D ≤ 1.0 mm). (4) Fertilizer rate influenced root length and surface area up to 130 days after sowing but affected ARD throughout the growing season such that seedlings treated with 50 mg N had smaller ARD than seedlings treated with 100 mg N. (5) As the growing season progressed, SI-media had significantly higher EC compared to OI-media and EC increased with increasing fertilizer rate under SI but not under OI. These results indicate that SI can produce larch seedlings of similar height and root collar diameter (RCD) compared to OI, but root systems are smaller overall with fewer small-diameter roots, which may be related to high EC levels in SI-media, which is exacerbated by the use of high rates of fertilizer. Therefore, the EC in the media should be monitored and adjusted by reducing fertilizer rates under SI.

Description: Record of Cariaco Basin near-surface [CO₃²⁻] from 1240-2007 C.E. derived from the area-density (shell weight (μg)/shell area (μm²)) of the planktonic foraminifer Globigerinoides ruber (pink). Area-density is used as a proxy for [CO₃²⁻] following the relationship presented in Marshall et al. (2013), using the two cores PL07-71-BC and CAR25-1