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  • Column liquid chromatography  (248)
  • Springer  (248)
  • American Chemical Society
  • Elsevier
  • International Union of Crystallography
  • 2015-2019
  • 2000-2004
  • 1990-1994  (163)
  • 1985-1989  (85)
Collection
Keywords
Publisher
  • Springer  (248)
  • American Chemical Society
  • Elsevier
  • International Union of Crystallography
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Determination of carbendazime in lettuce samples by SFE-HPLC (1994)
    Springer
    Chromatographia 38 (1994), S. 395-399 
    Details
    ISSN: 1612-1112
    Keywords: Supercritical fluid extraction ; Column liquid chromatography ; Carbendazime analysis ; Vegetable samples
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary An SFE-HPLC method for the determination of carbendazime in lettuce leaves is described. The method involves a prior lyophilization of the sample and subsequent extraction with supercritical carbon dioxide containing methanol. The extraction conditions are as follows: amount of lyophilized sample, 1 g; CO2 density, 0.75 g/ml; temperature, 50 °C; flow-rate, 1.8 ml/min; dynamic extraction time, 25 min. Carbendazime is determined with an octadecylsilane column, an acetonitrile/water 30∶70 mobile phase and fluorescence detection at 285/317 nm. Carbendazime recoveries from spiked samples were all close to 100%. A comparison with the results from a conventional method for the determination of carbendazime reveals the new method to be more rapid, simple and reproducible for samples with low concentrations of analyte.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02269786
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of tacrolimus (FK 506) in whole blood using liquid chromatography and fluorescence detection (1994)
    Springer
    Chromatographia 39 (1994), S. 490-496 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Precolumn derivatization ; Dansylhydrazine ; Fluorescence detection ; Tacrolimus (FK 506) in blood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A sensitive and selective liquid chromatographic method, using precolumn derivatization with dansylhydrazine followed by fluorescence detection, has been developed for the determination of tacrolimus (FK 506) in whole blood. After haemolysis, whole blood samples are extracted with diethyl ether and derivatized. After on-line removal of excess dansylhydrazine on a C18 precolumn, the derivative is loaded on to a C18 clean-up column, and a heart cut is subsequently transferred to a graphitized carbon column, where the final separation takes place. The method requires 1 ml of sample and has a limit of quantitation of 3 ng/ml. At the 15 ng/ml level the precision isca 10%, and the response is linear from the limit of quantitation toca 200 ng/ml of FK 506 in whole blood. The capacity of the method is 50 samples/day and about 1000 1-ml samples can be analyzed without changing either clean-up or separation column. Finally, the applicability of the method for therapeutic drug monitoring is shown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02278767
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular shape recognition capability of liquid-crystal bonded phases in reversed-phase high performance liquid chromatography (1994)
    Springer
    Chromatographia 38 (1994), S. 295-303 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Liquid crystal phases ; Molecular shape recognition ; Polycyclic aromatic hydrocarbons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The chromatographic retention behaviour of two liquidcrystal bonded phases have been evaluated using polycyclic aromatic hydrocarbons (PAHs) as the probe samples in reversed-phase high performance liquid chromatography (RP-HPLC). The results clearly indicate that these phases have better planarity and shape recognition capabilities than commercially-avaialble polymeric octadecylsilica (ODS) phases whose strong planarity and shape selectivities were found earlier. It can also be concluded from the chromatographic observations that the shape recognition capability of these phases is dependent on both mobile phase composition and column temperature, but that the effect of mobile phase and temperature on the shape selectivity work independently. The retention behaviour can be explained by changes in the phase structure with changes of eluent composition and temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02269771
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  • 4
    Electronic Resource
    Electronic Resource
    Quantitative structure chromatography relationships in reversed-phase high performance liquid chromatography: Prediction of retention behaviour using theoretically derived molecular properties (1993)
    Springer
    Chromatographia 37 (1993), S. 241-249 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Pattern recognition ; Principal components ; Multiple linear regressions ; M.O. properties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The use of theoretically calculated molecular properties as predictors for retention in reversed-phase HPLC has been explored. HPLC retention times have been measured for a series of 47 substituted aromatic molecules in three solvent mixtures and steric and electronic properties of these compounds have been derived using semi-empirical molecular orbital and empirical theoretical methods. A subset of the experimental data (a training set) was used to derive property-retention time relationships and the remaining data were then used to test the predictive capability of the methods. Good retention time prediction was possible using derived regression equations for individual solvents and after including solvent parameters it was possible to predict retention for all solvents using a single equation. This method showed that the most useful properties were calculated log P and the calculated dipole moment of the solutes, and the calculated solvent polarisability. In addition, 90% of the data were used to train an artificial neural network and the remaining 10% of the data used to test the network; excellent prediction was obtained, the neural network approach being as successful as the regression analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02278628
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  • 5
    Electronic Resource
    Electronic Resource
    Retention behavior of some monobasic penicillins and their quaternary ammonium ion pairs in reversed-phase high-performance liquid chromatography (1991)
    Springer
    Chromatographia 32 (1991), S. 436-440 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Ion-pair chromatography ; Quaternary ammonium ion pairs ; Penicillins ; Retention behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The retention behavior of some monobasic penicillins (penicillin G, penicillin V, oxacillin, cloxacillin and dicloxacillin) and their quaternary alkylammonium ion pairs has been studied in a reversed-phase high-performance liquid chromatographic system using Partisil 5 μm ODS-3 asstationary phase and mixtures of acetonitrile and aqueous phosphate buffers as mobile phases. The influence of pH, pairing-ion chain length and concentration, and column temperature on retention has been investigated and the observed behavior of the compounds during the chromatographic process has been discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02327974
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  • 6
    Electronic Resource
    Electronic Resource
    Simultaneous quantitative measurement of a new platelet activating factor antagonist (BN 50730) and its two main metabolites in human plasma and urine by LC-MS (1994)
    Springer
    Chromatographia 39 (1994), S. 228-238 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; LC/MS coupling ; Particle Beam interface ; Plasma and urine samples ; BN50730 and its metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A simple and sensitive assay has been developed for the quantitative measurement of a new platelet activating factor antagonist (BN50730), and its two main metabolites (BN50727 and BN50922), at the picomole level in human plasma and urine. The three compounds of interest and the internal standard (BN50765) were measured by combined LC-negative chemical ionization MS. A simple solid-liquid extraction procedure was used to isolate the parent drug and the two metabolites. The MS was tuned to monitor the intense ionm/z 333 generated in the ion source by a dissociative capture process. The assay was on 1 ml plasma or 0.1 ml urine and the quantitation limit was calculated as 1 ng·ml−1. The very low relative standard deviations and mean percentages of error calculated for within-day or between-day repeatability assays demonstrate the ruggedness of the technique for routine determination in biological fluids. Some preliminary results on the pharmacokinetics of the parent drug and its two main metabolites illustrate the applicability of this method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274505
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  • 7
    Electronic Resource
    Electronic Resource
    Bioanalysis of fluorouracil applying liquid chromatography and valve switching (1988)
    Springer
    Chromatographia 25 (1988), S. 806-810 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Ion-pair chromatography ; Valve switching ; Fluorouracil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Fluorouracil has been analyzed with a reversed-phase ion-pair liquid chromatographic system applying PRP-1 as the stationary phase. A valve switching technique was applied for the separation of the analyte and some other chemotherapeutic agents. The described procedure gives a rapid screening for the analyte in urine and plasma samples without interferences from late eluting solutes. Biological samples are pretreated by means of a liquid-liquid extraction resulting in a recovery of about 52% for plasma and urine with minimum detectable amounts of about 5ng/ml. The sensitivity and the selectivity of the procedure allows the monitoring of fluorouracil in body fluids and subsequent pharmaco-kinetic studies of the fluoropyrimidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02262089
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  • 8
    Electronic Resource
    Electronic Resource
    Application of HPLC mobile phase optimization methods to the detection of impurities in bulk drug steroids (1990)
    Springer
    Chromatographia 29 (1990), S. 338-346 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Mobile phase optimization ; Impurities in steroid drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Some mobile phase optimization methods have been used in developing a Reversed-Phase High-Performance Liquid Chromatography methodology for the determination of related impurities in bulk pharmaceutical steroids. Using two different approaches with binary and ternary mobile phase, the complete separation of 9-α-fluoroprednisolone acetate and its main potential impurities, at low concentration levels, has been achieved. This methodology may be applicable to other steroidal drugs and it is presented as an alternative to the thin-layer chromatography currently prescribed in official methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02261300
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  • 9
    Electronic Resource
    Electronic Resource
    Comparison of extraction methods for the determination of polycyclic aromatic hydrocarbons in soot samples (1991)
    Springer
    Chromatographia 31 (1991), S. 569-574 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Gas chromatography ; Polycyclic aromatic hydrocarbons ; Soot and air samples ; Liquid CO2 extraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The results of the analysis of polycyclic aromatic hydrocarbons (PAH) in soot and similar types of sample are often dependent on the extraction method applied, owing to carbonaceous substances present in these samples. The recoveries of three extraction methods, and ultrasonic ether, a Soxhlet toluene and a Soxhlet extraction with liquid CO2 were compared for a typical soot sample. Additionally the CO2 extraction was optimized with respect to the necessary number of transfers during the extraction and the proper method to remove the CO2 after extraction. Finally, the liquid chromatographic pretreatment of the extract, prior to gas chromatographic analyses of the PAH, was improved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279477
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  • 10
    Electronic Resource
    Electronic Resource
    Liquid chromatographic capacity factor as an indicator of lipophilicity in a series of betablocker drugs (1986)
    Springer
    Chromatographia 22 (1986), S. 48-50 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Betablocker drugs ; Lipophilicity ; Capacity factors ; Distribution coefficients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The reverse-phase, high-pressure liquid chromatographic capacity factors (k') of a series of 18 betablocking agents were determined in order to establish correlations with their distribution coefficient values (D), obtained from four bibliographic sources. Under the three pH conditions studied (3.5, 6.2 and 7.5) statistically significant linear correlations (p〈 0.002) between log k' and log D values were obtained for the four series studied. In this series it is concluded that the k' factor is a useful and reliable relative lipophilicity parameter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02257296
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