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  • 1
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    Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-07-10
    Description: Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR signalling can extend lifespan in a mammalian species was unknown. Here we report that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age. On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males. The effect was seen at three independent test sites in genetically heterogeneous mice, chosen to avoid genotype-specific effects on disease susceptibility. Disease patterns of rapamycin-treated mice did not differ from those of control mice. In a separate study, rapamycin fed to mice beginning at 270 days of age also increased survival in both males and females, based on an interim analysis conducted near the median survival point. Rapamycin may extend lifespan by postponing death from cancer, by retarding mechanisms of ageing, or both. To our knowledge, these are the first results to demonstrate a role for mTOR signalling in the regulation of mammalian lifespan, as well as pharmacological extension of lifespan in both genders. These findings have implications for further development of interventions targeting mTOR for the treatment and prevention of age-related diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786175/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786175/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrison, David E -- Strong, Randy -- Sharp, Zelton Dave -- Nelson, James F -- Astle, Clinton M -- Flurkey, Kevin -- Nadon, Nancy L -- Wilkinson, J Erby -- Frenkel, Krystyna -- Carter, Christy S -- Pahor, Marco -- Javors, Martin A -- Fernandez, Elizabeth -- Miller, Richard A -- AG022303/AG/NIA NIH HHS/ -- AG022307/AG/NIA NIH HHS/ -- AG022308/AG/NIA NIH HHS/ -- AG025707/AG/NIA NIH HHS/ -- AG13319/AG/NIA NIH HHS/ -- P30 AG013319/AG/NIA NIH HHS/ -- P30 AG013319-119002/AG/NIA NIH HHS/ -- P30 AG013319-129002/AG/NIA NIH HHS/ -- P30 AG013319-139002/AG/NIA NIH HHS/ -- P30 AG013319-149002/AG/NIA NIH HHS/ -- P30 AG025707/AG/NIA NIH HHS/ -- U01 AG022303/AG/NIA NIH HHS/ -- U01 AG022307/AG/NIA NIH HHS/ -- U01 AG022307-01/AG/NIA NIH HHS/ -- U01 AG022307-02/AG/NIA NIH HHS/ -- U01 AG022307-03/AG/NIA NIH HHS/ -- U01 AG022307-04/AG/NIA NIH HHS/ -- U01 AG022307-05/AG/NIA NIH HHS/ -- U01 AG022307-05S1/AG/NIA NIH HHS/ -- U01 AG022308/AG/NIA NIH HHS/ -- England -- Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Jackson Laboratory, Bar Harbor, Maine 04609, USA. david.harrison@jax.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19587680" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Aging/*drug effects/genetics/*physiology ; Animals ; Carrier Proteins/antagonists & inhibitors/metabolism ; Diet ; Disease Susceptibility ; Female ; Longevity/*drug effects/*genetics/physiology ; Male ; Mice ; Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors/metabolism ; Sirolimus/*administration & dosage/*pharmacology ; Specific Pathogen-Free Organisms ; Survival Analysis ; TOR Serine-Threonine Kinases ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-25
    Description: The imprints of domestication and breed development on the genomes of livestock likely differ from those of companion animals. A deep draft sequence assembly of shotgun reads from a single Hereford female and comparative sequences sampled from six additional breeds were used to develop probes to interrogate 37,470 single-nucleotide polymorphisms (SNPs) in 497 cattle from 19 geographically and biologically diverse breeds. These data show that cattle have undergone a rapid recent decrease in effective population size from a very large ancestral population, possibly due to bottlenecks associated with domestication, selection, and breed formation. Domestication and artificial selection appear to have left detectable signatures of selection within the cattle genome, yet the current levels of diversity within breeds are at least as great as exists within humans.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735092/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735092/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bovine HapMap Consortium -- Gibbs, Richard A -- Taylor, Jeremy F -- Van Tassell, Curtis P -- Barendse, William -- Eversole, Kellye A -- Gill, Clare A -- Green, Ronnie D -- Hamernik, Debora L -- Kappes, Steven M -- Lien, Sigbjorn -- Matukumalli, Lakshmi K -- McEwan, John C -- Nazareth, Lynne V -- Schnabel, Robert D -- Weinstock, George M -- Wheeler, David A -- Ajmone-Marsan, Paolo -- Boettcher, Paul J -- Caetano, Alexandre R -- Garcia, Jose Fernando -- Hanotte, Olivier -- Mariani, Paola -- Skow, Loren C -- Sonstegard, Tad S -- Williams, John L -- Diallo, Boubacar -- Hailemariam, Lemecha -- Martinez, Mario L -- Morris, Chris A -- Silva, Luiz O C -- Spelman, Richard J -- Mulatu, Woudyalew -- Zhao, Keyan -- Abbey, Colette A -- Agaba, Morris -- Araujo, Flabio R -- Bunch, Rowan J -- Burton, James -- Gorni, Chiara -- Olivier, Hanotte -- Harrison, Blair E -- Luff, Bill -- Machado, Marco A -- Mwakaya, Joel -- Plastow, Graham -- Sim, Warren -- Smith, Timothy -- Thomas, Merle B -- Valentini, Alessio -- Williams, Paul -- Womack, James -- Woolliams, John A -- Liu, Yue -- Qin, Xiang -- Worley, Kim C -- Gao, Chuan -- Jiang, Huaiyang -- Moore, Stephen S -- Ren, Yanru -- Song, Xing-Zhi -- Bustamante, Carlos D -- Hernandez, Ryan D -- Muzny, Donna M -- Patil, Shobha -- San Lucas, Anthony -- Fu, Qing -- Kent, Matthew P -- Vega, Richard -- Matukumalli, Aruna -- McWilliam, Sean -- Sclep, Gert -- Bryc, Katarzyna -- Choi, Jungwoo -- Gao, Hong -- Grefenstette, John J -- Murdoch, Brenda -- Stella, Alessandra -- Villa-Angulo, Rafael -- Wright, Mark -- Aerts, Jan -- Jann, Oliver -- Negrini, Riccardo -- Goddard, Mike E -- Hayes, Ben J -- Bradley, Daniel G -- Barbosa da Silva, Marcos -- Lau, Lilian P L -- Liu, George E -- Lynn, David J -- Panzitta, Francesca -- Dodds, Ken G -- R01 GM083606/GM/NIGMS NIH HHS/ -- R01 GM083606-02/GM/NIGMS NIH HHS/ -- U54 HG003273/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2009 Apr 24;324(5926):528-32. doi: 10.1126/science.1167936.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19390050" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breeding ; Cattle/*genetics ; Female ; Gene Frequency ; *Genetic Variation ; *Genome ; Male ; Molecular Sequence Data ; Mutation ; *Polymorphism, Single Nucleotide ; Population Density
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Fire in the Earth system (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-25
    Description: Fire is a worldwide phenomenon that appears in the geological record soon after the appearance of terrestrial plants. Fire influences global ecosystem patterns and processes, including vegetation distribution and structure, the carbon cycle, and climate. Although humans and fire have always coexisted, our capacity to manage fire remains imperfect and may become more difficult in the future as climate change alters fire regimes. This risk is difficult to assess, however, because fires are still poorly represented in global models. Here, we discuss some of the most important issues involved in developing a better understanding of the role of fire in the Earth system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowman, David M J S -- Balch, Jennifer K -- Artaxo, Paulo -- Bond, William J -- Carlson, Jean M -- Cochrane, Mark A -- D'Antonio, Carla M -- Defries, Ruth S -- Doyle, John C -- Harrison, Sandy P -- Johnston, Fay H -- Keeley, Jon E -- Krawchuk, Meg A -- Kull, Christian A -- Marston, J Brad -- Moritz, Max A -- Prentice, I Colin -- Roos, Christopher I -- Scott, Andrew C -- Swetnam, Thomas W -- van der Werf, Guido R -- Pyne, Stephen J -- New York, N.Y. -- Science. 2009 Apr 24;324(5926):481-4. doi: 10.1126/science.1163886.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Tasmania, Hobart, TAS 7001, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19390038" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Carbon ; Climate ; Earth (Planet) ; *Ecosystem ; *Fires ; Humans ; Plants
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Structure of SARS coronavirus spike receptor-binding domain complexed with receptor (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-09-17
    Description: The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the RBD bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase. The atomic details at the interface between the two proteins clarify the importance of residue changes that facilitate efficient cross-species infection and human-to-human transmission. The structure of the RBD suggests ways to make truncated disulfide-stabilized RBD variants for use in the design of coronavirus vaccines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Fang -- Li, Wenhui -- Farzan, Michael -- Harrison, Stephen C -- AI061601/AI/NIAID NIH HHS/ -- CA13202/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1864-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Laboratory of Molecular Medicine, 320 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16166518" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Antibodies, Viral/immunology ; Binding Sites ; Carboxypeptidases/*chemistry/metabolism ; Cell Line ; Crystallography, X-Ray ; Disease Outbreaks ; Epitopes ; Glycosylation ; Humans ; Hydrophobic and Hydrophilic Interactions ; Membrane Glycoproteins/*chemistry/genetics/immunology/*metabolism ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Peptidyl-Dipeptidase A ; Protein Conformation ; Protein Structure, Tertiary ; Receptors, Virus/*chemistry/metabolism ; SARS Virus/*chemistry/genetics/physiology ; Severe Acute Respiratory Syndrome/transmission/*virology ; Species Specificity ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins/*chemistry/genetics/immunology/*metabolism ; Viral Vaccines ; Viverridae/virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Ivory-billed woodpecker (Campephilus principalis) persists in continental North America (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-30
    Description: The ivory-billed woodpecker (Campephilus principalis), long suspected to be extinct, has been rediscovered in the Big Woods region of eastern Arkansas. Visual encounters during 2004 and 2005, and analysis of a video clip from April 2004, confirm the existence of at least one male. Acoustic signatures consistent with Campephilus display drums also have been heard from the region. Extensive efforts to find birds away from the primary encounter site remain unsuccessful, but potential habitat for a thinly distributed source population is vast (over 220,000 hectares).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fitzpatrick, John W -- Lammertink, Martjan -- Luneau, M David Jr -- Gallagher, Tim W -- Harrison, Bobby R -- Sparling, Gene M -- Rosenberg, Kenneth V -- Rohrbaugh, Ronald W -- Swarthout, Elliott C H -- Wrege, Peter H -- Swarthout, Sara Barker -- Dantzker, Marc S -- Charif, Russell A -- Barksdale, Timothy R -- Remsen, J V Jr -- Simon, Scott D -- Zollner, Douglas -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1460-2. Epub 2005 Apr 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cornell Laboratory of Ornithology, Cornell University, 159 Sapsucker Woods Road, Ithaca, NY 14850, USA. jwf7@cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860589" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arkansas ; Biological Evolution ; *Birds ; Conservation of Natural Resources ; Ecology ; Male ; Video Recording
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Ecology: The Convention on Biological Diversity's 2010 target (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balmford, Andrew -- Bennun, Leon -- Brink, Ben Ten -- Cooper, David -- Cote, Isabelle M -- Crane, Peter -- Dobson, Andrew -- Dudley, Nigel -- Dutton, Ian -- Green, Rhys E -- Gregory, Richard D -- Harrison, Jeremy -- Kennedy, Elizabeth T -- Kremen, Claire -- Leader-Williams, Nigel -- Lovejoy, Thomas E -- Mace, Georgina -- May, Robert -- Mayaux, Phillipe -- Morling, Paul -- Phillips, Joanna -- Redford, Kent -- Ricketts, Taylor H -- Rodriguez, Jon Paul -- Sanjayan, M -- Schei, Peter J -- van Jaarsveld, Albert S -- Walther, Bruno A -- New York, N.Y. -- Science. 2005 Jan 14;307(5707):212-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cambridge University and University of Cape Town.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15653489" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; *Conservation of Natural Resources ; *Ecology ; Ecosystem ; Humans ; Interdisciplinary Communication ; International Cooperation ; Models, Biological ; Models, Theoretical ; Public Policy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-26
    Description: Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250984/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250984/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garten, Rebecca J -- Davis, C Todd -- Russell, Colin A -- Shu, Bo -- Lindstrom, Stephen -- Balish, Amanda -- Sessions, Wendy M -- Xu, Xiyan -- Skepner, Eugene -- Deyde, Varough -- Okomo-Adhiambo, Margaret -- Gubareva, Larisa -- Barnes, John -- Smith, Catherine B -- Emery, Shannon L -- Hillman, Michael J -- Rivailler, Pierre -- Smagala, James -- de Graaf, Miranda -- Burke, David F -- Fouchier, Ron A M -- Pappas, Claudia -- Alpuche-Aranda, Celia M -- Lopez-Gatell, Hugo -- Olivera, Hiram -- Lopez, Irma -- Myers, Christopher A -- Faix, Dennis -- Blair, Patrick J -- Yu, Cindy -- Keene, Kimberly M -- Dotson, P David Jr -- Boxrud, David -- Sambol, Anthony R -- Abid, Syed H -- St George, Kirsten -- Bannerman, Tammy -- Moore, Amanda L -- Stringer, David J -- Blevins, Patricia -- Demmler-Harrison, Gail J -- Ginsberg, Michele -- Kriner, Paula -- Waterman, Steve -- Smole, Sandra -- Guevara, Hugo F -- Belongia, Edward A -- Clark, Patricia A -- Beatrice, Sara T -- Donis, Ruben -- Katz, Jacqueline -- Finelli, Lyn -- Bridges, Carolyn B -- Shaw, Michael -- Jernigan, Daniel B -- Uyeki, Timothy M -- Smith, Derek J -- Klimov, Alexander I -- Cox, Nancy J -- DP1 OD000490-01/OD/NIH HHS/ -- DP1-OD000490-01/OD/NIH HHS/ -- HHSN266200700010C/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2009 Jul 10;325(5937):197-201. doi: 10.1126/science.1176225. Epub 2009 May 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19465683" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/immunology ; Antigens, Viral/genetics/*immunology ; Disease Outbreaks ; Evolution, Molecular ; Genes, Viral ; Genetic Variation ; Genome, Viral ; Hemagglutination Inhibition Tests ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry/genetics/immunology ; Humans ; Influenza A Virus, H1N1 Subtype/classification/*genetics/*immunology/isolation & ; purification ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza A virus/genetics ; Influenza, Human/epidemiology/immunology/*virology ; Mutation ; Neuraminidase/genetics ; Orthomyxoviridae Infections/veterinary/virology ; Phylogeny ; Reassortant Viruses/genetics ; Swine ; Swine Diseases/virology ; Viral Matrix Proteins/genetics ; Viral Nonstructural Proteins/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    BIOSAFETY. Safeguarding gene drive experiments in the laboratory (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-08-01
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692367/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692367/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Akbari, Omar S -- Bellen, Hugo J -- Bier, Ethan -- Bullock, Simon L -- Burt, Austin -- Church, George M -- Cook, Kevin R -- Duchek, Peter -- Edwards, Owain R -- Esvelt, Kevin M -- Gantz, Valentino M -- Golic, Kent G -- Gratz, Scott J -- Harrison, Melissa M -- Hayes, Keith R -- James, Anthony A -- Kaufman, Thomas C -- Knoblich, Juergen -- Malik, Harmit S -- Matthews, Kathy A -- O'Connor-Giles, Kate M -- Parks, Annette L -- Perrimon, Norbert -- Port, Fillip -- Russell, Steven -- Ueda, Ryu -- Wildonger, Jill -- R01 AI070654/AI/NIAID NIH HHS/ -- R01 AI110713/AI/NIAID NIH HHS/ -- T32 GM007133/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2015 Aug 28;349(6251):927-9. doi: 10.1126/science.aac7932. Epub 2015 Jul 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, Univ. of California, Riverside, CA 92507, USA. Center for Disease Vector Research, Institute for Integrative Genome Biology, Univ. of California, Riverside, CA 92507, USA. ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA. ; Section of Cell and Developmental Biology, Univ. of California, San Diego, La Jolla, CA 92095, USA. kevin.esvelt@wyss.harvard.edu ebier@ucsd.edu. ; Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. ; Department of Life Sciences, Imperial College London, Silwood Park, Ascot, Berks SL5 7PY, UK. ; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. ; Bloomington Drosophila Stock Center, Department of Biology, Indiana Univ., Bloomington, IN 47405, USA. ; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria. ; CSIRO Centre for Environment and Life Sciences, Underwood Avenue, Floreat, WA 6014, Australia. ; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA. kevin.esvelt@wyss.harvard.edu ebier@ucsd.edu. ; Section of Cell and Developmental Biology, Univ. of California, San Diego, La Jolla, CA 92095, USA. ; Department of Biology, Univ. of Utah, Salt Lake City, UT 84112, USA. ; Laboratory of Genetics, Univ. of Wisconsin-Madison, Madison, WI 53706, USA. ; Department of Biomolecular Chemistry, Univ. of Wisconsin-Madison, Madison, WI 53706, USA. ; CSIRO Biosecurity Flagship, General Post Of ce Box 1538, Hobart, Tasmania, 7001, Australia. ; Departments of Microbiology & Molecular Genetics and Molecular Biology & Biochemistry, Univ. of California at Irvine, Irvine, CA 92697, USA. ; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. ; Laboratory of Genetics, Univ. of Wisconsin-Madison, Madison, WI 53706, USA. Laboratory of Cell and Molecular Biology, Univ. of Wisconsin-Madison, Madison, WI 53706, USA. ; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. ; Department of Genetics, Univ. of Cambridge, Cambridge, Cambridgeshire CB2 3EH, UK. ; Department of Genetics, Graduate Univ. for Advanced Studies, Mishima, Shizuoka 411-8540, Japan. NIG-Fly Stock Center, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan. ; Department of Biochemistry, Univ. of Wisconsin-Madison, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26229113" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CRISPR-Cas Systems ; *Clustered Regularly Interspaced Short Palindromic Repeats ; *Containment of Biohazards ; Endonucleases/metabolism ; *Genetic Engineering ; *Genetic Research ; Genome ; *Organisms, Genetically Modified ; *Safety
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    DEVELOPMENT AND ENVIRONMENT. Balancing hydropower and biodiversity in the Amazon, Congo, and Mekong (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-01-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Winemiller, K O -- McIntyre, P B -- Castello, L -- Fluet-Chouinard, E -- Giarrizzo, T -- Nam, S -- Baird, I G -- Darwall, W -- Lujan, N K -- Harrison, I -- Stiassny, M L J -- Silvano, R A M -- Fitzgerald, D B -- Pelicice, F M -- Agostinho, A A -- Gomes, L C -- Albert, J S -- Baran, E -- Petrere, M Jr -- Zarfl, C -- Mulligan, M -- Sullivan, J P -- Arantes, C C -- Sousa, L M -- Koning, A A -- Hoeinghaus, D J -- Sabaj, M -- Lundberg, J G -- Armbruster, J -- Thieme, M L -- Petry, P -- Zuanon, J -- Torrente Vilara, G -- Snoeks, J -- Ou, C -- Rainboth, W -- Pavanelli, C S -- Akama, A -- van Soesbergen, A -- Saenz, L -- New York, N.Y. -- Science. 2016 Jan 8;351(6269):128-9. doi: 10.1126/science.aac7082.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉See supplementary materials for author affiliations. k-winemiller@tamu.edu. ; See supplementary materials for author affiliations.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26744397" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Congo ; Conservation of Natural Resources ; Fisheries ; *Fishes ; Fresh Water ; Mekong Valley ; *Power Plants ; Risk ; *Rivers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Global effects of land use on local terrestrial biodiversity (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-04-04
    Description: Human activities, especially conversion and degradation of habitats, are causing global biodiversity declines. How local ecological assemblages are responding is less clear--a concern given their importance for many ecosystem functions and services. We analysed a terrestrial assemblage database of unprecedented geographic and taxonomic coverage to quantify local biodiversity responses to land use and related changes. Here we show that in the worst-affected habitats, these pressures reduce within-sample species richness by an average of 76.5%, total abundance by 39.5% and rarefaction-based richness by 40.3%. We estimate that, globally, these pressures have already slightly reduced average within-sample richness (by 13.6%), total abundance (10.7%) and rarefaction-based richness (8.1%), with changes showing marked spatial variation. Rapid further losses are predicted under a business-as-usual land-use scenario; within-sample richness is projected to fall by a further 3.4% globally by 2100, with losses concentrated in biodiverse but economically poor countries. Strong mitigation can deliver much more positive biodiversity changes (up to a 1.9% average increase) that are less strongly related to countries' socioeconomic status.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newbold, Tim -- Hudson, Lawrence N -- Hill, Samantha L L -- Contu, Sara -- Lysenko, Igor -- Senior, Rebecca A -- Borger, Luca -- Bennett, Dominic J -- Choimes, Argyrios -- Collen, Ben -- Day, Julie -- De Palma, Adriana -- Diaz, Sandra -- Echeverria-Londono, Susy -- Edgar, Melanie J -- Feldman, Anat -- Garon, Morgan -- Harrison, Michelle L K -- Alhusseini, Tamera -- Ingram, Daniel J -- Itescu, Yuval -- Kattge, Jens -- Kemp, Victoria -- Kirkpatrick, Lucinda -- Kleyer, Michael -- Correia, David Laginha Pinto -- Martin, Callum D -- Meiri, Shai -- Novosolov, Maria -- Pan, Yuan -- Phillips, Helen R P -- Purves, Drew W -- Robinson, Alexandra -- Simpson, Jake -- Tuck, Sean L -- Weiher, Evan -- White, Hannah J -- Ewers, Robert M -- Mace, Georgina M -- Scharlemann, Jorn P W -- Purvis, Andy -- BB/F017324/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- England -- Nature. 2015 Apr 2;520(7545):45-50. doi: 10.1038/nature14324.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] United Nations Environment Programme World Conservation Monitoring Centre, 219 Huntingdon Road, Cambridge CB3 0DL, UK. [2] Computational Science Laboratory, Microsoft Research Cambridge, 21 Station Road, Cambridge CB1 2FB, UK. ; Department of Life Sciences, Natural History Museum, Cromwell Road, London SW7 5BD, UK. ; 1] United Nations Environment Programme World Conservation Monitoring Centre, 219 Huntingdon Road, Cambridge CB3 0DL, UK. [2] Department of Life Sciences, Natural History Museum, Cromwell Road, London SW7 5BD, UK. ; Department of Life Sciences, Imperial College London, Silwood Park, London SL5 7PY, UK. ; United Nations Environment Programme World Conservation Monitoring Centre, 219 Huntingdon Road, Cambridge CB3 0DL, UK. ; Department of Biosciences, College of Science, Swansea University, Singleton Park, Swansea SA2 8PP, UK. ; 1] Department of Life Sciences, Natural History Museum, Cromwell Road, London SW7 5BD, UK. [2] Department of Life Sciences, Imperial College London, Silwood Park, London SL5 7PY, UK. ; Department of Genetics, Evolution and Environment, Centre for Biodiversity and Environment Research, University College London, Gower Street, London WC1E 6BT, UK. ; Instituto Multidisciplinario de Biologia Vegetal (CONICET-UNC) and FCEFyN, Universidad Nacional de Cordoba, Casilla de Correo 495, 5000 Cordoba, Argentina. ; Deptartment of Zoology, Faculty of Life Sciences, Tel-Aviv University, 6997801 Tel Aviv, Israel. ; 1] Max Planck Institute for Biogeochemistry, Hans Knoll Strasse 10, 07743 Jena, Germany. [2] German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany. ; Landscape Ecology Group, Institute of Biology and Environmental Sciences, University of Oldenburg, D-26111 Oldenburg, Germany. ; Computational Science Laboratory, Microsoft Research Cambridge, 21 Station Road, Cambridge CB1 2FB, UK. ; Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, UK. ; Biology Department, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54701, USA. ; 1] United Nations Environment Programme World Conservation Monitoring Centre, 219 Huntingdon Road, Cambridge CB3 0DL, UK. [2] School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25832402" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Conservation of Natural Resources/trends ; Ecology/trends ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; *Human Activities ; Models, Biological ; Population Dynamics ; Species Specificity
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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